Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications
Oral mucosa and salivary gland are composed of complex and dynamic networks of extracellular matrix, multiple cell types, vasculature, and various biochemical agents. Two-dimensional (2D) cell culture is commonly used in testing new drugs and experimental therapies. However, 2D cell culture cannot f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/11/12/1066 |
| _version_ | 1797546139259502592 |
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| author | Akram Abdo Almansoori Bongju Kim Jong-Ho Lee Simon D. Tran |
| author_facet | Akram Abdo Almansoori Bongju Kim Jong-Ho Lee Simon D. Tran |
| author_sort | Akram Abdo Almansoori |
| collection | DOAJ |
| description | Oral mucosa and salivary gland are composed of complex and dynamic networks of extracellular matrix, multiple cell types, vasculature, and various biochemical agents. Two-dimensional (2D) cell culture is commonly used in testing new drugs and experimental therapies. However, 2D cell culture cannot fully replicate the architecture, physiological, and pathological microenvironment of living human oral mucosa and salivary glands. Recent microengineering techniques offer state of the science cell culture models that can recapitulate human organ structures and functions. This narrative review describes emerging in vitro models of oral and salivary gland tissue such as 3D cell culture models, spheroid and organoid models, tissue-on-a-chip, and functional decellularized scaffolds. Clinical applications of these models are also discussed in this review. |
| first_indexed | 2024-03-10T14:25:50Z |
| format | Article |
| id | doaj.art-04e9834203a94a1295e0262d8bf80f5a |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T14:25:50Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-04e9834203a94a1295e0262d8bf80f5a2023-11-20T22:58:18ZengMDPI AGMicromachines2072-666X2020-11-011112106610.3390/mi11121066Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical ApplicationsAkram Abdo Almansoori0Bongju Kim1Jong-Ho Lee2Simon D. Tran3Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, KoreaClinical Translational Research Center for Dental Science, Seoul National University Dental Hospital, Seoul 03080, KoreaDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul 03080, KoreaMcGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC H3A 0C7, CanadaOral mucosa and salivary gland are composed of complex and dynamic networks of extracellular matrix, multiple cell types, vasculature, and various biochemical agents. Two-dimensional (2D) cell culture is commonly used in testing new drugs and experimental therapies. However, 2D cell culture cannot fully replicate the architecture, physiological, and pathological microenvironment of living human oral mucosa and salivary glands. Recent microengineering techniques offer state of the science cell culture models that can recapitulate human organ structures and functions. This narrative review describes emerging in vitro models of oral and salivary gland tissue such as 3D cell culture models, spheroid and organoid models, tissue-on-a-chip, and functional decellularized scaffolds. Clinical applications of these models are also discussed in this review.https://www.mdpi.com/2072-666X/11/12/1066microengineeringoral mucosasalivary gland3D cell culture |
| spellingShingle | Akram Abdo Almansoori Bongju Kim Jong-Ho Lee Simon D. Tran Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications Micromachines microengineering oral mucosa salivary gland 3D cell culture |
| title | Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications |
| title_full | Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications |
| title_fullStr | Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications |
| title_full_unstemmed | Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications |
| title_short | Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications |
| title_sort | tissue engineering of oral mucosa and salivary gland disease modeling and clinical applications |
| topic | microengineering oral mucosa salivary gland 3D cell culture |
| url | https://www.mdpi.com/2072-666X/11/12/1066 |
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