Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice
We addressed both brain pre-surgical functional and neurophysiological aspects of the hand representation in 18 right-handed patients harboring a highly malignant brain tumor in the sensorimotor (SM) cortex (10 in the left hemisphere, LH, and 8 in the right hemisphere, RH) and 10 healthy controls, w...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/10/1274 |
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| author | Elisa Cargnelutti Giada Pauletto Tamara Ius Lorenzo Verriello Marta Maieron Miran Skrap Barbara Tomasino |
| author_facet | Elisa Cargnelutti Giada Pauletto Tamara Ius Lorenzo Verriello Marta Maieron Miran Skrap Barbara Tomasino |
| author_sort | Elisa Cargnelutti |
| collection | DOAJ |
| description | We addressed both brain pre-surgical functional and neurophysiological aspects of the hand representation in 18 right-handed patients harboring a highly malignant brain tumor in the sensorimotor (SM) cortex (10 in the left hemisphere, LH, and 8 in the right hemisphere, RH) and 10 healthy controls, who performed an fMRI hand-clenching task with both hands alternatively. We extracted the main ROI in the SM cortex and compared ROI values and volumes between hemispheres and groups, in addition to their motor neurophysiological measures. Hemispheric asymmetry in the fMRI signal was observed for healthy controls, namely higher signal for the left-hand movements, but not for either patients’ groups. ROI values, although altered in patients vs. controls, did not differ significantly between groups. ROI volumes associated with right-hand movement were lower for both patients’ groups vs. controls, and those associated with left-hand movement were lower in the RH group vs. all groups. These results are relevant to interpret potential preoperative plasticity and make inferences about postoperative plasticity and can be integrated in the surgical planning to increase surgery success and postoperative prognosis and quality of life. |
| first_indexed | 2024-03-09T20:34:36Z |
| format | Article |
| id | doaj.art-04ebc8a620824b9fa89a2bf12a2c6ebc |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T20:34:36Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-04ebc8a620824b9fa89a2bf12a2c6ebc2023-11-23T23:12:48ZengMDPI AGBrain Sciences2076-34252022-09-011210127410.3390/brainsci12101274Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical PracticeElisa Cargnelutti0Giada Pauletto1Tamara Ius2Lorenzo Verriello3Marta Maieron4Miran Skrap5Barbara Tomasino6Scientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, 33037 Udine, ItalySOC Neurologia, Azienda Sanitaria Universitaria Friuli Centrale ASU FC, 33100 Udine, ItalySOC Neurochirurgia, Azienda Sanitaria Universitaria Friuli Centrale ASU FC, 33100 Udine, ItalySOC Neurologia, Azienda Sanitaria Universitaria Friuli Centrale ASU FC, 33100 Udine, ItalySOC Fisica Sanitaria, Azienda Sanitaria Universitaria Friuli Centrale ASU FC, 33100 Udine, ItalySOC Neurochirurgia, Azienda Sanitaria Universitaria Friuli Centrale ASU FC, 33100 Udine, ItalyScientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, 33037 Udine, ItalyWe addressed both brain pre-surgical functional and neurophysiological aspects of the hand representation in 18 right-handed patients harboring a highly malignant brain tumor in the sensorimotor (SM) cortex (10 in the left hemisphere, LH, and 8 in the right hemisphere, RH) and 10 healthy controls, who performed an fMRI hand-clenching task with both hands alternatively. We extracted the main ROI in the SM cortex and compared ROI values and volumes between hemispheres and groups, in addition to their motor neurophysiological measures. Hemispheric asymmetry in the fMRI signal was observed for healthy controls, namely higher signal for the left-hand movements, but not for either patients’ groups. ROI values, although altered in patients vs. controls, did not differ significantly between groups. ROI volumes associated with right-hand movement were lower for both patients’ groups vs. controls, and those associated with left-hand movement were lower in the RH group vs. all groups. These results are relevant to interpret potential preoperative plasticity and make inferences about postoperative plasticity and can be integrated in the surgical planning to increase surgery success and postoperative prognosis and quality of life.https://www.mdpi.com/2076-3425/12/10/1274hand clenchingfunctional asymmetrysensorimotor cortexhighly malignant brain tumorsplasticitycontrol-group selection |
| spellingShingle | Elisa Cargnelutti Giada Pauletto Tamara Ius Lorenzo Verriello Marta Maieron Miran Skrap Barbara Tomasino Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice Brain Sciences hand clenching functional asymmetry sensorimotor cortex highly malignant brain tumors plasticity control-group selection |
| title | Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice |
| title_full | Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice |
| title_fullStr | Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice |
| title_full_unstemmed | Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice |
| title_short | Hemispheric Asymmetry of the Hand Motor Representations in Patients with Highly Malignant Brain Tumors: Implications for Surgery and Clinical Practice |
| title_sort | hemispheric asymmetry of the hand motor representations in patients with highly malignant brain tumors implications for surgery and clinical practice |
| topic | hand clenching functional asymmetry sensorimotor cortex highly malignant brain tumors plasticity control-group selection |
| url | https://www.mdpi.com/2076-3425/12/10/1274 |
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