AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT
The problem of comorbidity is one of the most important problems in clinical immunology. The commonest non-organ specific autoimmune diseases — rheumatoid arthritis (RA) and psoriasis are linked with accelerated atherosclerosis progression and increased cardiovascular risk. In autoimmune disorders a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/952 |
| _version_ | 1797237660171894784 |
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| author | I. V. Shirinskiy O. A. Polovnikova V. S. Shirinskiy |
| author_facet | I. V. Shirinskiy O. A. Polovnikova V. S. Shirinskiy |
| author_sort | I. V. Shirinskiy |
| collection | DOAJ |
| description | The problem of comorbidity is one of the most important problems in clinical immunology. The commonest non-organ specific autoimmune diseases — rheumatoid arthritis (RA) and psoriasis are linked with accelerated atherosclerosis progression and increased cardiovascular risk. In autoimmune disorders associated with comorbidities the use of multitargeted drugs holds a promise. Examples of such drugs include the inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (statins) and agonists of PPARα (fibrates) which exert antiinflammatory, immunomodulating, and anti-atherogenic activities. In this review we summarize our own research on statins and fibrates pre-clinical pharmacology, their efficacy and safety in patients with RA and psoriasis. |
| first_indexed | 2024-03-08T12:22:43Z |
| format | Article |
| id | doaj.art-04eed303132142668aa30899237b9f25 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:16Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-04eed303132142668aa30899237b9f252024-03-28T07:49:04ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)358362898AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENTI. V. Shirinskiy0O. A. Polovnikova1V. S. Shirinskiy2Research Institute of Clinical Immunology SB RAMSResearch Institute of Clinical Immunology SB RAMSResearch Institute of Clinical Immunology SB RAMSThe problem of comorbidity is one of the most important problems in clinical immunology. The commonest non-organ specific autoimmune diseases — rheumatoid arthritis (RA) and psoriasis are linked with accelerated atherosclerosis progression and increased cardiovascular risk. In autoimmune disorders associated with comorbidities the use of multitargeted drugs holds a promise. Examples of such drugs include the inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (statins) and agonists of PPARα (fibrates) which exert antiinflammatory, immunomodulating, and anti-atherogenic activities. In this review we summarize our own research on statins and fibrates pre-clinical pharmacology, their efficacy and safety in patients with RA and psoriasis.https://www.actabiomedica.ru/jour/article/view/952rheumatoid arthritispsoriasisstatinsfibrates |
| spellingShingle | I. V. Shirinskiy O. A. Polovnikova V. S. Shirinskiy AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT Acta Biomedica Scientifica rheumatoid arthritis psoriasis statins fibrates |
| title | AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT |
| title_full | AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT |
| title_fullStr | AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT |
| title_full_unstemmed | AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT |
| title_short | AUTOIMMUNE DISEASES AND ATHEROSCLEROSIS - PROBLEMS OF TREATMENT |
| title_sort | autoimmune diseases and atherosclerosis problems of treatment |
| topic | rheumatoid arthritis psoriasis statins fibrates |
| url | https://www.actabiomedica.ru/jour/article/view/952 |
| work_keys_str_mv | AT ivshirinskiy autoimmunediseasesandatherosclerosisproblemsoftreatment AT oapolovnikova autoimmunediseasesandatherosclerosisproblemsoftreatment AT vsshirinskiy autoimmunediseasesandatherosclerosisproblemsoftreatment |