Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors
Abstract Background Photodynamic therapy (PDT) efficacy of bismuth sulfide (Bi2S3) semiconductor has been severely restricted by its electron–hole pairs (e−−h+) separation inefficiency and oxygen (O2) deficiency in tumors, which greatly hinders reactive oxygen species (ROS) generation and further cl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-024-02391-x |
| _version_ | 1797246972775628800 |
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| author | Hanwen Jiang Jingxian Sun Fucong Liu Yuanjiao Zhao Xin Chen Changsong Dai Zhaohui Wen |
| author_facet | Hanwen Jiang Jingxian Sun Fucong Liu Yuanjiao Zhao Xin Chen Changsong Dai Zhaohui Wen |
| author_sort | Hanwen Jiang |
| collection | DOAJ |
| description | Abstract Background Photodynamic therapy (PDT) efficacy of bismuth sulfide (Bi2S3) semiconductor has been severely restricted by its electron–hole pairs (e−−h+) separation inefficiency and oxygen (O2) deficiency in tumors, which greatly hinders reactive oxygen species (ROS) generation and further clinical application of Bi2S3 nanoparticles (NPs) in biomedicine. Results Herein, novel Bi2S3/titanium carbide (Ti3C2) two-dimensional nano-heterostructures (NHs) are designed to realize multimode PDT of synchronous O2 self-supply and ROS generation combined with highly efficient photothermal tumor elimination for hypoxic tumor therapy. Bi2S3/Ti3C2 NHs were synthesized via the in situ synthesis method starting from Ti3C2 nanosheets (NSs), a classical type of MXene nanostructure. Compared to simple Bi2S3 NPs, Bi2S3/Ti3C2 NHs significantly extend the absorption to the near-infrared (NIR) region and enhance the photocatalytic activity owing to the improved photogenerated carrier separation, where the hole on the valence band (VB) of Bi2S3 can react with water to supply O2 for the electron on the Ti3C2 NSs to generate ·O2 − and ·OH through electron transfer. Furthermore, they also achieve 1O2 generation through energy transfer due to O2 self-supply. After the modification of triphenylphosphium bromide (TPP) on Bi2S3/Ti3C2 NHs, systematic in vitro and in vivo evaluations were conducted, revealing that the synergistic-therapeutic outcome of this nanoplatform enables complete eradication of the U251 tumors without recurrence by NIR laser irradiation, and it can be used for computed tomography (CT) imaging because of the strong X-ray attenuation ability. Conclusion This work expands the phototherapeutic effect of Bi2S3-based nanoplatforms, providing a new strategy for hypoxic tumor theranostics. |
| first_indexed | 2024-04-24T19:51:18Z |
| format | Article |
| id | doaj.art-04eefb12e58b4434b21bc0f0b2e78e28 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-24T19:51:18Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-04eefb12e58b4434b21bc0f0b2e78e282024-03-24T12:32:43ZengBMCJournal of Nanobiotechnology1477-31552024-03-0122111810.1186/s12951-024-02391-xBi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumorsHanwen Jiang0Jingxian Sun1Fucong Liu2Yuanjiao Zhao3Xin Chen4Changsong Dai5Zhaohui Wen6Department of Neurology, Brain Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityKey Colleges and Universities Laboratory of Neurosurgery in Heilongjiang ProvinceDepartment of Neurology, Brain Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Neurology, Brain Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityKey Colleges and Universities Laboratory of Neurosurgery in Heilongjiang ProvinceMIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of TechnologyDepartment of Neurology, Brain Ultrasound, The First Affiliated Hospital of Harbin Medical UniversityAbstract Background Photodynamic therapy (PDT) efficacy of bismuth sulfide (Bi2S3) semiconductor has been severely restricted by its electron–hole pairs (e−−h+) separation inefficiency and oxygen (O2) deficiency in tumors, which greatly hinders reactive oxygen species (ROS) generation and further clinical application of Bi2S3 nanoparticles (NPs) in biomedicine. Results Herein, novel Bi2S3/titanium carbide (Ti3C2) two-dimensional nano-heterostructures (NHs) are designed to realize multimode PDT of synchronous O2 self-supply and ROS generation combined with highly efficient photothermal tumor elimination for hypoxic tumor therapy. Bi2S3/Ti3C2 NHs were synthesized via the in situ synthesis method starting from Ti3C2 nanosheets (NSs), a classical type of MXene nanostructure. Compared to simple Bi2S3 NPs, Bi2S3/Ti3C2 NHs significantly extend the absorption to the near-infrared (NIR) region and enhance the photocatalytic activity owing to the improved photogenerated carrier separation, where the hole on the valence band (VB) of Bi2S3 can react with water to supply O2 for the electron on the Ti3C2 NSs to generate ·O2 − and ·OH through electron transfer. Furthermore, they also achieve 1O2 generation through energy transfer due to O2 self-supply. After the modification of triphenylphosphium bromide (TPP) on Bi2S3/Ti3C2 NHs, systematic in vitro and in vivo evaluations were conducted, revealing that the synergistic-therapeutic outcome of this nanoplatform enables complete eradication of the U251 tumors without recurrence by NIR laser irradiation, and it can be used for computed tomography (CT) imaging because of the strong X-ray attenuation ability. Conclusion This work expands the phototherapeutic effect of Bi2S3-based nanoplatforms, providing a new strategy for hypoxic tumor theranostics.https://doi.org/10.1186/s12951-024-02391-xNano-heterostructurePhotothermal therapyPhotodynamic therapyHypoxic tumorTumor theranostics |
| spellingShingle | Hanwen Jiang Jingxian Sun Fucong Liu Yuanjiao Zhao Xin Chen Changsong Dai Zhaohui Wen Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors Journal of Nanobiotechnology Nano-heterostructure Photothermal therapy Photodynamic therapy Hypoxic tumor Tumor theranostics |
| title | Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors |
| title_full | Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors |
| title_fullStr | Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors |
| title_full_unstemmed | Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors |
| title_short | Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors |
| title_sort | bi2s3 ti3c2 tpp nano heterostructures induced by near infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors |
| topic | Nano-heterostructure Photothermal therapy Photodynamic therapy Hypoxic tumor Tumor theranostics |
| url | https://doi.org/10.1186/s12951-024-02391-x |
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