Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells

Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells

The antigen-independent, strong proliferative responses of naive CD8+ T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors. This type of proliferation is mainly driven by common gamma-chain (γc) cytokines, such as IL-2, IL-7, and IL-15, present at abnormally high...

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Bibliographic Details
Main Authors:	Gil-Woo Lee, Sung-Woo Lee, Juhee Kim, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Series:	Frontiers in Immunology
Subjects:	interleukin-2 naive CD8+ T cells antigen-independent proliferation Janus kinase 3 activated CD4+ T cells CD4+ regulatory T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.616898/full

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