Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block
Peripheral nerve blocks are commonly preferred worldwide for the purposes of anesthesia application and postoperative analgesia. In this study, we investigated the effects of phenytoin which has a similar mechanism to local anesthetics in terms of the duration of analgesia and quality. The study was...
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Society of Turaz Bilim
2018-12-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=302121 |
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| author | Ahmet Selim Ozkan Sedat Akbas Mehmet Akif Durak Mehmet Ali Erdogan Hakan Parlakpinar Nigar Vardi Onurhal Ozhan Ali Ozer |
| author_facet | Ahmet Selim Ozkan Sedat Akbas Mehmet Akif Durak Mehmet Ali Erdogan Hakan Parlakpinar Nigar Vardi Onurhal Ozhan Ali Ozer |
| author_sort | Ahmet Selim Ozkan |
| collection | DOAJ |
| description | Peripheral nerve blocks are commonly preferred worldwide for the purposes of anesthesia application and postoperative analgesia. In this study, we investigated the effects of phenytoin which has a similar mechanism to local anesthetics in terms of the duration of analgesia and quality. The study was performed on 32 Sprague-Dawley male rats. Rats were randomly grouped into 4 groups. Group S: Sham group (n: 8); 0,2 ml saline perineural unilateral sciatic nerve. Group L: Perineural levobupivacaine (0,2 ml 0,5% levobupivacaine, n: 8); Group Ph: Perineural phenytoin (0,2 ml 62,5 mg / kg, n: 8); Group L + PH: Perineural phenytoin and levobupivacaine (0,2 ml 0,5% levobupivacaine + 62,5 mg / kg phenytoin, n: 8). Hot-plate and tail- flick tests were performed to measure acute thermal pain and histological changes were evaluated. The latency time at 30 minute in Group L+Ph were significantly increased when compared to the other groups during evaluation of the hot plate test. There was a significant difference in terms of latency time at 30 minute in Group L+Ph in the Tail Flick test and the latency time in Group L+Ph was longer when compared to the other groups (p [Med-Science 2018; 7(4.000): 891-7] |
| first_indexed | 2024-03-08T06:52:38Z |
| format | Article |
| id | doaj.art-04efc534ca064cea98168a8e90762a26 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:52:38Z |
| publishDate | 2018-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-04efc534ca064cea98168a8e90762a262024-02-03T06:40:22ZengSociety of Turaz BilimMedicine Science2147-06342018-12-0174891710.5455/medscience.2018.07.8899302121Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve blockAhmet Selim Ozkan0Sedat AkbasMehmet Akif DurakMehmet Ali ErdoganHakan ParlakpinarNigar VardiOnurhal OzhanAli OzerInonu University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Malatya, Turkey Inonu Univesity, Faculty of Medicine, Department of Neurosurgery, Malatya, Turkey Inonu University, Faculty of Medicine, Department of Medical Pharmacology, Malatya, Turkey Inonu University, Faculty of Medicine, Department of Histology and Embriology, Malatya, Turkey Inonu University, Faculty of Medicine, Department of Health and Etic, Malatya, TurkeyPeripheral nerve blocks are commonly preferred worldwide for the purposes of anesthesia application and postoperative analgesia. In this study, we investigated the effects of phenytoin which has a similar mechanism to local anesthetics in terms of the duration of analgesia and quality. The study was performed on 32 Sprague-Dawley male rats. Rats were randomly grouped into 4 groups. Group S: Sham group (n: 8); 0,2 ml saline perineural unilateral sciatic nerve. Group L: Perineural levobupivacaine (0,2 ml 0,5% levobupivacaine, n: 8); Group Ph: Perineural phenytoin (0,2 ml 62,5 mg / kg, n: 8); Group L + PH: Perineural phenytoin and levobupivacaine (0,2 ml 0,5% levobupivacaine + 62,5 mg / kg phenytoin, n: 8). Hot-plate and tail- flick tests were performed to measure acute thermal pain and histological changes were evaluated. The latency time at 30 minute in Group L+Ph were significantly increased when compared to the other groups during evaluation of the hot plate test. There was a significant difference in terms of latency time at 30 minute in Group L+Ph in the Tail Flick test and the latency time in Group L+Ph was longer when compared to the other groups (p [Med-Science 2018; 7(4.000): 891-7]http://www.ejmanager.com/fulltextpdf.php?mno=302121Phenytoinlevobupivacaineratsciatic nerve block |
| spellingShingle | Ahmet Selim Ozkan Sedat Akbas Mehmet Akif Durak Mehmet Ali Erdogan Hakan Parlakpinar Nigar Vardi Onurhal Ozhan Ali Ozer Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block Medicine Science Phenytoin levobupivacaine rat sciatic nerve block |
| title | Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block |
| title_full | Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block |
| title_fullStr | Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block |
| title_full_unstemmed | Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block |
| title_short | Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block |
| title_sort | effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block |
| topic | Phenytoin levobupivacaine rat sciatic nerve block |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=302121 |
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