Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability
Background: Motion Sickness increases risk of performance deficits and safety of flight concerns. The etiology of motion sickness is poorly understood. Here, we attempted to quantify the physiological effects of motion sickness on static balance and determine the genetic predictors associated with t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023016201 |
| _version_ | 1797851755701075968 |
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| author | Ashley Turner Michael Markey Peter Le Ali Reiter Cyndy Cox Stacy Simmons M.B. Rao Lorenna Altman Kermit Davis Dustin Huber Jonathan S. Dufour William Marras Amit Bhattacharya |
| author_facet | Ashley Turner Michael Markey Peter Le Ali Reiter Cyndy Cox Stacy Simmons M.B. Rao Lorenna Altman Kermit Davis Dustin Huber Jonathan S. Dufour William Marras Amit Bhattacharya |
| author_sort | Ashley Turner |
| collection | DOAJ |
| description | Background: Motion Sickness increases risk of performance deficits and safety of flight concerns. The etiology of motion sickness is poorly understood. Here, we attempted to quantify the physiological effects of motion sickness on static balance and determine the genetic predictors associated with these effects. Methods: 16 subjects underwent a disorientation stimulus to induce motion sickness. Motion sickness susceptibility was identified using the Motion Sickness Susceptibility Questionnaire. Postural balance outcomes were measured using two tasks, and small ribonucleic acid profiles were assessed with blood draws before motion sickness stimulus. Differences in postural sway before and after the stimulus as well as effect modification of susceptibility were assessed. A random forest followed by regression tree analysis was constructed for each postural sway variable to determine top genetic and covariate predictors. Findings: Significant differences existed in mean postural balance responses between before and after stimulus. Individuals with longer stimulus survival experienced a greater (but insignificant) perception of sway, even if not displaying increased sway for all conditions. Circulation small ribonucleic acids were differentially expressed between individuals with long and short stimulus survival, many of these microRNA have purported targets in genes related to vestibular disorders. Interpretation: We found motion sickness produces transient motor dysfunction in a healthy military population. Small ribonucleic acids were differentially expressed between subjects with long and short stimulus survival times. |
| first_indexed | 2024-04-09T19:22:58Z |
| format | Article |
| id | doaj.art-04f13d17d65249a2957904693d36da15 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:22:58Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-04f13d17d65249a2957904693d36da152023-04-05T08:25:22ZengElsevierHeliyon2405-84402023-03-0193e14413Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stabilityAshley Turner0Michael Markey1Peter Le2Ali Reiter3Cyndy Cox4Stacy Simmons5M.B. Rao6Lorenna Altman7Kermit Davis8Dustin Huber9Jonathan S. Dufour10William Marras11Amit Bhattacharya12Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USADepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA; Corresponding author. Center for Genomics Research, Department of Biochemistry and Molecular Biology, Wright State University, 3640 Colonel Glenn Hwy., Dayton, OH 45435-0001, USA.NAMRU-D and Air Force Research Laboratory, 711th Human Performance Wing, WPAFB, OH 45433, USADepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USADepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USADepartment of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USADepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USADepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USADepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USANAMRU-D and Air Force Research Laboratory, 711th Human Performance Wing, WPAFB, OH 45433, USASpine Research Institute, The Ohio State University, Columbus, OH, USASpine Research Institute, The Ohio State University, Columbus, OH, USADepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USABackground: Motion Sickness increases risk of performance deficits and safety of flight concerns. The etiology of motion sickness is poorly understood. Here, we attempted to quantify the physiological effects of motion sickness on static balance and determine the genetic predictors associated with these effects. Methods: 16 subjects underwent a disorientation stimulus to induce motion sickness. Motion sickness susceptibility was identified using the Motion Sickness Susceptibility Questionnaire. Postural balance outcomes were measured using two tasks, and small ribonucleic acid profiles were assessed with blood draws before motion sickness stimulus. Differences in postural sway before and after the stimulus as well as effect modification of susceptibility were assessed. A random forest followed by regression tree analysis was constructed for each postural sway variable to determine top genetic and covariate predictors. Findings: Significant differences existed in mean postural balance responses between before and after stimulus. Individuals with longer stimulus survival experienced a greater (but insignificant) perception of sway, even if not displaying increased sway for all conditions. Circulation small ribonucleic acids were differentially expressed between individuals with long and short stimulus survival, many of these microRNA have purported targets in genes related to vestibular disorders. Interpretation: We found motion sickness produces transient motor dysfunction in a healthy military population. Small ribonucleic acids were differentially expressed between subjects with long and short stimulus survival times.http://www.sciencedirect.com/science/article/pii/S2405844023016201Motion sicknessBalancemicroRNAMilitary |
| spellingShingle | Ashley Turner Michael Markey Peter Le Ali Reiter Cyndy Cox Stacy Simmons M.B. Rao Lorenna Altman Kermit Davis Dustin Huber Jonathan S. Dufour William Marras Amit Bhattacharya Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability Heliyon Motion sickness Balance microRNA Military |
| title | Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability |
| title_full | Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability |
| title_fullStr | Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability |
| title_full_unstemmed | Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability |
| title_short | Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability |
| title_sort | disorientation effects circulating small ribonucleic acid and genetic susceptibility on static postural stability |
| topic | Motion sickness Balance microRNA Military |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023016201 |
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