Single-cell RNA sequencing in juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children, with onset before age 16 and lasting for more than 6 weeks. JIA is a highly heterogeneous condition with various consequences for health and quality of life. For some JIA patients, earl...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223002088 |
| _version_ | 1827267059191382016 |
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| author | Xiwen Luo Xuemei Tang |
| author_facet | Xiwen Luo Xuemei Tang |
| author_sort | Xiwen Luo |
| collection | DOAJ |
| description | Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children, with onset before age 16 and lasting for more than 6 weeks. JIA is a highly heterogeneous condition with various consequences for health and quality of life. For some JIA patients, early detection and intervention remain challenging. As a result, further investigation of the complex and unknown mechanisms underlying JIA is required. Advances in technology now allow us to describe the biological heterogeneity and function of individual cell populations in JIA. Through this review, we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis. |
| first_indexed | 2024-03-12T11:52:50Z |
| format | Article |
| id | doaj.art-04f34473aefd401ab103c913df6a1f73 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:27:43Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-04f34473aefd401ab103c913df6a1f732024-04-28T05:04:13ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-03-01112633644Single-cell RNA sequencing in juvenile idiopathic arthritisXiwen Luo0Xuemei Tang1Department of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaDepartment of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Key Laboratory of Child Infection and Immunity, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Corresponding author. Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China.Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children, with onset before age 16 and lasting for more than 6 weeks. JIA is a highly heterogeneous condition with various consequences for health and quality of life. For some JIA patients, early detection and intervention remain challenging. As a result, further investigation of the complex and unknown mechanisms underlying JIA is required. Advances in technology now allow us to describe the biological heterogeneity and function of individual cell populations in JIA. Through this review, we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.http://www.sciencedirect.com/science/article/pii/S2352304223002088Juvenile idiopathic arthritisMacrophageMacrophage activation syndromeMonocyteSingle-cell RNA sequencingSynoviocyte |
| spellingShingle | Xiwen Luo Xuemei Tang Single-cell RNA sequencing in juvenile idiopathic arthritis Genes and Diseases Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte Single-cell RNA sequencing Synoviocyte |
| title | Single-cell RNA sequencing in juvenile idiopathic arthritis |
| title_full | Single-cell RNA sequencing in juvenile idiopathic arthritis |
| title_fullStr | Single-cell RNA sequencing in juvenile idiopathic arthritis |
| title_full_unstemmed | Single-cell RNA sequencing in juvenile idiopathic arthritis |
| title_short | Single-cell RNA sequencing in juvenile idiopathic arthritis |
| title_sort | single cell rna sequencing in juvenile idiopathic arthritis |
| topic | Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte Single-cell RNA sequencing Synoviocyte |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223002088 |
| work_keys_str_mv | AT xiwenluo singlecellrnasequencinginjuvenileidiopathicarthritis AT xuemeitang singlecellrnasequencinginjuvenileidiopathicarthritis |