Opioid prescription patterns among adults with cerebral palsy and spina bifida
Background: Pain is the most common symptom of cerebral palsy and spina bifida (CP/SB). The objective of this study was to compare the opioid prescription patterns for differing pain types and overlapping pain among adults living with and without CP/SB. Methods: Privately-insured beneficiaries were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022012063 |
| _version_ | 1818163275761713152 |
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| author | Mark D. Peterson Neil Kamdar Heidi J. Haapala Chad Brummett Edward A. Hurvitz |
| author_facet | Mark D. Peterson Neil Kamdar Heidi J. Haapala Chad Brummett Edward A. Hurvitz |
| author_sort | Mark D. Peterson |
| collection | DOAJ |
| description | Background: Pain is the most common symptom of cerebral palsy and spina bifida (CP/SB). The objective of this study was to compare the opioid prescription patterns for differing pain types and overlapping pain among adults living with and without CP/SB. Methods: Privately-insured beneficiaries were included if they had CP/SB (n = 22,647). Adults without CP/SB were also included as controls (n = 931,528). Oral morphine equivalents (OMEs) were calculated. A multivariable logistic regression was used to analyze the association between CP/SB and OMEs, across the three pain categories: (1) no pain, (2) isolated pain, and (3) pain multimorbidity. Results: Adults living with CP/SB had a higher OME prescription pattern per year than adults without CP or SB (8,981.0 ± 5,183.0 vs. 4,549.1 ± 2,988.0), and for no pain (4,010.8 ± 828.1 vs. 1,623.53 ± 47.5), isolated pain (7,179.9 ± 378.8 vs. 3,531.0 ± 131.0), and pain multimorbidity (15,752.4 ± 1,395.5 vs. 8,492.9 ± 398.0) (all p < 0.001), and differences were to a clinically meaningful extent. Adjusted odds ratios (OR) for prescribed OMEs were higher for adults with CP/SB vs. control and (1) no pain (OR: 1.51; 95%CI: 1.46, 1.56), (2) isolated pain (OR: 1.48; 95%CI: 1.44, 1.52), and (3) pain multimorbidity (OR: 1.79; 95%CI: 1.72, 1.86). Conclusions: Adults with CP/SB obtain significantly higher prescription of OMEs than adults without CP/SB. |
| first_indexed | 2024-12-11T16:46:59Z |
| format | Article |
| id | doaj.art-04f41a59128845489bd68359ee497f58 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-11T16:46:59Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-04f41a59128845489bd68359ee497f582022-12-22T00:58:11ZengElsevierHeliyon2405-84402022-07-0187e09918Opioid prescription patterns among adults with cerebral palsy and spina bifidaMark D. Peterson0Neil Kamdar1Heidi J. Haapala2Chad Brummett3Edward A. Hurvitz4Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA; Institute for Healthcare Policy and Innovation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA; Corresponding author.Institute for Healthcare Policy and Innovation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Obstetrics and Gynecology, Michigan Medicine, University of Michigan, USA; Department of Emergency Medicine, Michigan Medicine, University of Michigan, USA; Department of Surgery, Michigan Medicine, University of Michigan, USADepartment of Anesthesiology, Michigan Medicine, University of Michigan, USADepartment of Anesthesiology, Michigan Medicine, University of Michigan, USADepartment of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI, USABackground: Pain is the most common symptom of cerebral palsy and spina bifida (CP/SB). The objective of this study was to compare the opioid prescription patterns for differing pain types and overlapping pain among adults living with and without CP/SB. Methods: Privately-insured beneficiaries were included if they had CP/SB (n = 22,647). Adults without CP/SB were also included as controls (n = 931,528). Oral morphine equivalents (OMEs) were calculated. A multivariable logistic regression was used to analyze the association between CP/SB and OMEs, across the three pain categories: (1) no pain, (2) isolated pain, and (3) pain multimorbidity. Results: Adults living with CP/SB had a higher OME prescription pattern per year than adults without CP or SB (8,981.0 ± 5,183.0 vs. 4,549.1 ± 2,988.0), and for no pain (4,010.8 ± 828.1 vs. 1,623.53 ± 47.5), isolated pain (7,179.9 ± 378.8 vs. 3,531.0 ± 131.0), and pain multimorbidity (15,752.4 ± 1,395.5 vs. 8,492.9 ± 398.0) (all p < 0.001), and differences were to a clinically meaningful extent. Adjusted odds ratios (OR) for prescribed OMEs were higher for adults with CP/SB vs. control and (1) no pain (OR: 1.51; 95%CI: 1.46, 1.56), (2) isolated pain (OR: 1.48; 95%CI: 1.44, 1.52), and (3) pain multimorbidity (OR: 1.79; 95%CI: 1.72, 1.86). Conclusions: Adults with CP/SB obtain significantly higher prescription of OMEs than adults without CP/SB.http://www.sciencedirect.com/science/article/pii/S2405844022012063Cerebral palsySpina bifidaEpidemiologyChronic painOpioidHydrocodone |
| spellingShingle | Mark D. Peterson Neil Kamdar Heidi J. Haapala Chad Brummett Edward A. Hurvitz Opioid prescription patterns among adults with cerebral palsy and spina bifida Heliyon Cerebral palsy Spina bifida Epidemiology Chronic pain Opioid Hydrocodone |
| title | Opioid prescription patterns among adults with cerebral palsy and spina bifida |
| title_full | Opioid prescription patterns among adults with cerebral palsy and spina bifida |
| title_fullStr | Opioid prescription patterns among adults with cerebral palsy and spina bifida |
| title_full_unstemmed | Opioid prescription patterns among adults with cerebral palsy and spina bifida |
| title_short | Opioid prescription patterns among adults with cerebral palsy and spina bifida |
| title_sort | opioid prescription patterns among adults with cerebral palsy and spina bifida |
| topic | Cerebral palsy Spina bifida Epidemiology Chronic pain Opioid Hydrocodone |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022012063 |
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