The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study
The evidence of metformin’s effect on dementia is conflicting. This study investigates the association between metformin use and the risk of dementia among patients with diabetes mellitus (DM). This study included patients with new-onset DM between 2002 and 2013. We divided the patients into patient...
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/5/738 |
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| author | Kuang-Hua Huang Ya-Fang Tsai Chiachi Bonnie Lee Shuo-Yan Gau Tung-Han Tsai Ning-Jen Chung Chien-Ying Lee |
| author_facet | Kuang-Hua Huang Ya-Fang Tsai Chiachi Bonnie Lee Shuo-Yan Gau Tung-Han Tsai Ning-Jen Chung Chien-Ying Lee |
| author_sort | Kuang-Hua Huang |
| collection | DOAJ |
| description | The evidence of metformin’s effect on dementia is conflicting. This study investigates the association between metformin use and the risk of dementia among patients with diabetes mellitus (DM). This study included patients with new-onset DM between 2002 and 2013. We divided the patients into patients who used metformin and patients who did not. Two models were used to assess metformin use: the cumulative defined daily dose (cDDD) of metformin use and the intensity of metformin use. This study with 3-year and 5-year follow-ups investigated the risk of dementia among patients with DM who used metformin. At the 3-year follow-up, patients who received cDDD < 300 had an odds ratio (OR) of developing dementia of 0.92 (95% confidence interval [CI] = 0.89–0.96); patients who used metformin at intensities <10 and 10–25 DDD/month had ORs of 0.92 (95% CI: 0.87–0.97) and 0.92 (95% CI: 0.85–1.00), respectively. Metformin use at cDDD 300–500 (OR = 0.80, 95% CI = 0.56–1.15) or >500 (OR = 1.48, 95% CI = 0.48–4.60) or at an intensity >25 DDD/month (OR = 0.84, 95% CI = 0.60–1.18) were not associated with an incident of dementia. There were similar results at the 5-year follow-up. Patients with a low intensity of metformin use had a lower risk of dementia. However, higher doses of metformin with higher intensity exhibited no protective role in dementia. Prospective clinical trials are warranted to evaluate the actual underlying mechanisms between metformin dosage and the risk of dementia. |
| first_indexed | 2024-03-11T03:35:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T03:35:03Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-04f6a40703904e688d948a211a57c75a2023-11-18T02:03:25ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113573810.3390/jpm13050738The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based StudyKuang-Hua Huang0Ya-Fang Tsai1Chiachi Bonnie Lee2Shuo-Yan Gau3Tung-Han Tsai4Ning-Jen Chung5Chien-Ying Lee6Department of Health Services Administration, China Medical University, Taichung 406040, TaiwanDepartment of Health Policy and Management, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Health Services Administration, China Medical University, Taichung 406040, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Health Services Administration, China Medical University, Taichung 406040, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Pharmacology, Chung Shan Medical University, Taichung 40201, TaiwanThe evidence of metformin’s effect on dementia is conflicting. This study investigates the association between metformin use and the risk of dementia among patients with diabetes mellitus (DM). This study included patients with new-onset DM between 2002 and 2013. We divided the patients into patients who used metformin and patients who did not. Two models were used to assess metformin use: the cumulative defined daily dose (cDDD) of metformin use and the intensity of metformin use. This study with 3-year and 5-year follow-ups investigated the risk of dementia among patients with DM who used metformin. At the 3-year follow-up, patients who received cDDD < 300 had an odds ratio (OR) of developing dementia of 0.92 (95% confidence interval [CI] = 0.89–0.96); patients who used metformin at intensities <10 and 10–25 DDD/month had ORs of 0.92 (95% CI: 0.87–0.97) and 0.92 (95% CI: 0.85–1.00), respectively. Metformin use at cDDD 300–500 (OR = 0.80, 95% CI = 0.56–1.15) or >500 (OR = 1.48, 95% CI = 0.48–4.60) or at an intensity >25 DDD/month (OR = 0.84, 95% CI = 0.60–1.18) were not associated with an incident of dementia. There were similar results at the 5-year follow-up. Patients with a low intensity of metformin use had a lower risk of dementia. However, higher doses of metformin with higher intensity exhibited no protective role in dementia. Prospective clinical trials are warranted to evaluate the actual underlying mechanisms between metformin dosage and the risk of dementia.https://www.mdpi.com/2075-4426/13/5/738dementiametformindiabetes mellitusdefined daily dose |
| spellingShingle | Kuang-Hua Huang Ya-Fang Tsai Chiachi Bonnie Lee Shuo-Yan Gau Tung-Han Tsai Ning-Jen Chung Chien-Ying Lee The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study Journal of Personalized Medicine dementia metformin diabetes mellitus defined daily dose |
| title | The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study |
| title_full | The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study |
| title_fullStr | The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study |
| title_full_unstemmed | The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study |
| title_short | The Correlation between Metformin Use and Incident Dementia in Patients with New-Onset Diabetes Mellitus: A Population-Based Study |
| title_sort | correlation between metformin use and incident dementia in patients with new onset diabetes mellitus a population based study |
| topic | dementia metformin diabetes mellitus defined daily dose |
| url | https://www.mdpi.com/2075-4426/13/5/738 |
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