Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism
Molecularly imprinted polymers (MIPs), as magnetic extraction adsorbents, are used for the selective, rapid determination and extraction of dexamethasone and hydrocortisone in skincare products. Therefore, in this paper, magnetic molecularly imprinted polymers (MMIPs) and magnetic non-molecularly im...
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MDPI AG
2024-03-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/14/5/2077 |
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| author | Fatma Aouaini Nadia Bouaziz Ahlem Cherif Haifa A. Alyousef Abdelmottaleb Ben Lamine |
| author_facet | Fatma Aouaini Nadia Bouaziz Ahlem Cherif Haifa A. Alyousef Abdelmottaleb Ben Lamine |
| author_sort | Fatma Aouaini |
| collection | DOAJ |
| description | Molecularly imprinted polymers (MIPs), as magnetic extraction adsorbents, are used for the selective, rapid determination and extraction of dexamethasone and hydrocortisone in skincare products. Therefore, in this paper, magnetic molecularly imprinted polymers (MMIPs) and magnetic non-molecularly imprinted polymers (MNIPs) were utilized as adsorbents to describe the adsorption phenomena of dexamethasone and hydrocortisone. This interpretation, based on a statistical physics theory, applies the multilayer model with saturation to comprehend the adsorption of the drugs. Results obtained via numerical simulation revealed that dexamethasone and hydrocortisone adsorption happens via a non-parallel orientation on the surfaces of MMIPs and MNIPs, and they also showed that the adsorption amount of the MMIPs for the template molecule was notably greater than that of the MNIPs at the same initial concentration. The adsorption energy values retrieved from the data analysis ranged between 7.65 and 15.77 kJ/mol, indicating that the extraction and determination of dexamethasone and hydrocortisone is a physisorption process. Moreover, the distribution of a site’s energy was calculated to confirm the physical nature of the interactions between adsorbate/adsorbent and the heterogeneity of the surfaces of the MMIPs and MNIPs. Finally, the thermodynamic interpretation confirmed the exothermicity and spontaneous nature of the adsorption of these drugs on the tested adsorbents. |
| first_indexed | 2024-04-25T00:33:58Z |
| format | Article |
| id | doaj.art-04f7c29fd3244f4783444d9b78dff241 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-25T00:33:58Z |
| publishDate | 2024-03-01 |
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| series | Applied Sciences |
| spelling | doaj.art-04f7c29fd3244f4783444d9b78dff2412024-03-12T16:40:01ZengMDPI AGApplied Sciences2076-34172024-03-01145207710.3390/app14052077Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics FormalismFatma Aouaini0Nadia Bouaziz1Ahlem Cherif2Haifa A. Alyousef3Abdelmottaleb Ben Lamine4Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi ArabiaLaboratory of Quantum and Statistical Physics, LR18ES18, Faculty of Sciences of Monastir, Monastir University, Monastir 5000, TunisiaDepartment of Physics, College of Science, Jouf University, Sakaka P.O. Box 2014, Saudi ArabiaDepartment of Physics, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi ArabiaLaboratory of Quantum and Statistical Physics, LR18ES18, Faculty of Sciences of Monastir, Monastir University, Monastir 5000, TunisiaMolecularly imprinted polymers (MIPs), as magnetic extraction adsorbents, are used for the selective, rapid determination and extraction of dexamethasone and hydrocortisone in skincare products. Therefore, in this paper, magnetic molecularly imprinted polymers (MMIPs) and magnetic non-molecularly imprinted polymers (MNIPs) were utilized as adsorbents to describe the adsorption phenomena of dexamethasone and hydrocortisone. This interpretation, based on a statistical physics theory, applies the multilayer model with saturation to comprehend the adsorption of the drugs. Results obtained via numerical simulation revealed that dexamethasone and hydrocortisone adsorption happens via a non-parallel orientation on the surfaces of MMIPs and MNIPs, and they also showed that the adsorption amount of the MMIPs for the template molecule was notably greater than that of the MNIPs at the same initial concentration. The adsorption energy values retrieved from the data analysis ranged between 7.65 and 15.77 kJ/mol, indicating that the extraction and determination of dexamethasone and hydrocortisone is a physisorption process. Moreover, the distribution of a site’s energy was calculated to confirm the physical nature of the interactions between adsorbate/adsorbent and the heterogeneity of the surfaces of the MMIPs and MNIPs. Finally, the thermodynamic interpretation confirmed the exothermicity and spontaneous nature of the adsorption of these drugs on the tested adsorbents.https://www.mdpi.com/2076-3417/14/5/2077cosmetic samplesdexamethasonehydrocortisoneMIPsstatistical physics |
| spellingShingle | Fatma Aouaini Nadia Bouaziz Ahlem Cherif Haifa A. Alyousef Abdelmottaleb Ben Lamine Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism Applied Sciences cosmetic samples dexamethasone hydrocortisone MIPs statistical physics |
| title | Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism |
| title_full | Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism |
| title_fullStr | Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism |
| title_full_unstemmed | Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism |
| title_short | Selective Extraction and Determination of Hydrocortisone and Dexamethasone in Skincare Cosmetics: Analytical Interpretation Using Statistical Physics Formalism |
| title_sort | selective extraction and determination of hydrocortisone and dexamethasone in skincare cosmetics analytical interpretation using statistical physics formalism |
| topic | cosmetic samples dexamethasone hydrocortisone MIPs statistical physics |
| url | https://www.mdpi.com/2076-3417/14/5/2077 |
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