Sleep apnea and autonomic dysfunction in patients with dementia
Sleep apnea is common sleep disorder that is associated with an is an increase in risk of many health conditions, including systemic hypertension, stroke, atrial fibrillation, and heart failure. The predominant underlying pathophysiological mechanism for elevated risk of these conditions in patients...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.951147/full |
| _version_ | 1829096120370855936 |
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| author | Michelle Herberts Bhanuprakash Kolla Travis Paul Praveen Mekala Meghna P. Mansukhani |
| author_facet | Michelle Herberts Bhanuprakash Kolla Travis Paul Praveen Mekala Meghna P. Mansukhani |
| author_sort | Michelle Herberts |
| collection | DOAJ |
| description | Sleep apnea is common sleep disorder that is associated with an is an increase in risk of many health conditions, including systemic hypertension, stroke, atrial fibrillation, and heart failure. The predominant underlying pathophysiological mechanism for elevated risk of these conditions in patients with sleep apnea is thought to involve autonomic dysfunction in the form of sympathetic overactivity. Autonomic dysfunction is also associated with several neurodegenerative disorders and sleep apnea, in turn, has been shown to be associated with an increased risk of development of mild cognitive impairment and various types of dementia. Rapid eye movement sleep behavior disorder, which is also associated with an increased risk of alpha synucleiopathy-related dementia, is also linked with autonomic dysfunction. In this article we explore the relationship between sleep apnea, autonomic dysfunction, rapid eye movement sleep behavior disorder and dementia. This article describes the various autonomic dysfunction that are thought to occur in the context of sleep apnea. And illustrate the mechanisms by which sleep apnea, through its impact on autonomic dysfunction could potentially result in dementia. We also review the evidence examining the impact of treatment of sleep apnea on autonomic dysfunction and cognitive outcomes. |
| first_indexed | 2024-04-11T08:51:31Z |
| format | Article |
| id | doaj.art-04f8c7c1f4fe4ca39a0a53dca0dcd0d6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T08:51:31Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-04f8c7c1f4fe4ca39a0a53dca0dcd0d62022-12-22T04:33:33ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.951147951147Sleep apnea and autonomic dysfunction in patients with dementiaMichelle Herberts0Bhanuprakash Kolla1Travis Paul2Praveen Mekala3Meghna P. Mansukhani4Center for Sleep Medicine, Mayo Clinic, Rochester, MN, United StatesCenter for Sleep Medicine, Mayo Clinic, Rochester, MN, United StatesMayo Clinic Health System, Southwest Minnesota, Mankato, MN, United StatesMayo Clinic Health System, Southwest Minnesota, Mankato, MN, United StatesCenter for Sleep Medicine, Mayo Clinic, Rochester, MN, United StatesSleep apnea is common sleep disorder that is associated with an is an increase in risk of many health conditions, including systemic hypertension, stroke, atrial fibrillation, and heart failure. The predominant underlying pathophysiological mechanism for elevated risk of these conditions in patients with sleep apnea is thought to involve autonomic dysfunction in the form of sympathetic overactivity. Autonomic dysfunction is also associated with several neurodegenerative disorders and sleep apnea, in turn, has been shown to be associated with an increased risk of development of mild cognitive impairment and various types of dementia. Rapid eye movement sleep behavior disorder, which is also associated with an increased risk of alpha synucleiopathy-related dementia, is also linked with autonomic dysfunction. In this article we explore the relationship between sleep apnea, autonomic dysfunction, rapid eye movement sleep behavior disorder and dementia. This article describes the various autonomic dysfunction that are thought to occur in the context of sleep apnea. And illustrate the mechanisms by which sleep apnea, through its impact on autonomic dysfunction could potentially result in dementia. We also review the evidence examining the impact of treatment of sleep apnea on autonomic dysfunction and cognitive outcomes.https://www.frontiersin.org/articles/10.3389/fnins.2022.951147/fullobstructive sleep apneaautonomic dysfunctiondementiaREM sleep behavior disorderautonomic control |
| spellingShingle | Michelle Herberts Bhanuprakash Kolla Travis Paul Praveen Mekala Meghna P. Mansukhani Sleep apnea and autonomic dysfunction in patients with dementia Frontiers in Neuroscience obstructive sleep apnea autonomic dysfunction dementia REM sleep behavior disorder autonomic control |
| title | Sleep apnea and autonomic dysfunction in patients with dementia |
| title_full | Sleep apnea and autonomic dysfunction in patients with dementia |
| title_fullStr | Sleep apnea and autonomic dysfunction in patients with dementia |
| title_full_unstemmed | Sleep apnea and autonomic dysfunction in patients with dementia |
| title_short | Sleep apnea and autonomic dysfunction in patients with dementia |
| title_sort | sleep apnea and autonomic dysfunction in patients with dementia |
| topic | obstructive sleep apnea autonomic dysfunction dementia REM sleep behavior disorder autonomic control |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.951147/full |
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