Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats
This study has been designed to compare the leaves extract of Ocimum tenuiflorum with soy lecithin and the leaves extract of Ocimum tenuiflorum only and find out its effectiveness on wound healing properties. Drug release study was also evaluated to obtain a brief idea on the release of the drug aft...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Academy of Sciences Malaysia
2021-05-01
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| Series: | ASM Science Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.32802/asmscj.2021.695 |
| _version_ | 1797902120915042304 |
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| author | Rabeta Mohd Salleh Rohini Jayaraman Mohd Nasir Che Mohd Yusoff |
| author_facet | Rabeta Mohd Salleh Rohini Jayaraman Mohd Nasir Che Mohd Yusoff |
| author_sort | Rabeta Mohd Salleh |
| collection | DOAJ |
| description | This study has been designed to compare the leaves extract of Ocimum tenuiflorum with soy lecithin and the leaves extract of Ocimum tenuiflorum only and find out its effectiveness on wound healing properties. Drug release study was also evaluated to obtain a brief idea on the release of the drug after consumption of the formulation and extract. The wound healing effectiveness study suggest that the formulated extract has better wound healing activity in comparison to extract which is more similar to the standard drug which was used as positive control. It was also found that the drug release activity of the formulation shows sustained release of the marker compound in when compared to the extract. Thus, it can be concluded that the improved wound healing activity of the formulation could be due to the sustained released of the compounds which present that act accordingly to improve the activity. Further study on its mechanism of action need to done to understand it activity better. |
| first_indexed | 2024-04-10T09:12:47Z |
| format | Article |
| id | doaj.art-04fad9a0337f468a99c137e1408058e7 |
| institution | Directory Open Access Journal |
| issn | 1823-6782 |
| language | English |
| last_indexed | 2024-04-10T09:12:47Z |
| publishDate | 2021-05-01 |
| publisher | Academy of Sciences Malaysia |
| record_format | Article |
| series | ASM Science Journal |
| spelling | doaj.art-04fad9a0337f468a99c137e1408058e72023-02-21T03:17:59ZengAcademy of Sciences MalaysiaASM Science Journal1823-67822021-05-01151610.32802/asmscj.2021.695695Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley RatsRabeta Mohd Salleh0Rohini JayaramanMohd Nasir Che Mohd YusoffUniversiti Sains MalaysiaThis study has been designed to compare the leaves extract of Ocimum tenuiflorum with soy lecithin and the leaves extract of Ocimum tenuiflorum only and find out its effectiveness on wound healing properties. Drug release study was also evaluated to obtain a brief idea on the release of the drug after consumption of the formulation and extract. The wound healing effectiveness study suggest that the formulated extract has better wound healing activity in comparison to extract which is more similar to the standard drug which was used as positive control. It was also found that the drug release activity of the formulation shows sustained release of the marker compound in when compared to the extract. Thus, it can be concluded that the improved wound healing activity of the formulation could be due to the sustained released of the compounds which present that act accordingly to improve the activity. Further study on its mechanism of action need to done to understand it activity better.https://doi.org/10.32802/asmscj.2021.695wound healingocimum tenuiflorumin vivosoy lecithin |
| spellingShingle | Rabeta Mohd Salleh Rohini Jayaraman Mohd Nasir Che Mohd Yusoff Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats ASM Science Journal wound healing ocimum tenuiflorum in vivo soy lecithin |
| title | Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats |
| title_full | Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats |
| title_fullStr | Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats |
| title_full_unstemmed | Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats |
| title_short | Comparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats |
| title_sort | comparative wound healing study of ocimum tenuiflorum leaves extract and its formulation on sprague dawley rats |
| topic | wound healing ocimum tenuiflorum in vivo soy lecithin |
| url | https://doi.org/10.32802/asmscj.2021.695 |
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