UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus))
ABSTRACT The aim of this research was to asses the acute toxicity of ethanolic extract of malaka leaves using lethal dose 50 (LD50) on mice (Mus musculus). Twenty male mice weighing between 20-30 g were randomly divided into 4 groups (group K1-K4) of 5 mice each. All mice in group K1, K2, K3, and K4...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Syiah Kuala
2016-09-01
|
| Series: | Jurnal Kedokteran Hewan |
| Subjects: | |
| Online Access: | https://jurnal.usk.ac.id/JKH/article/view/5137 |
| _version_ | 1827265206562062336 |
|---|---|
| author | T. Armansyah TR Sudi Indriany Amalia Sutriana Rosmaidar Rosmaidar Nuzul Asmilia Budianto Panjaitan Dwinna Aliza Hamdan Hamdan |
| author_facet | T. Armansyah TR Sudi Indriany Amalia Sutriana Rosmaidar Rosmaidar Nuzul Asmilia Budianto Panjaitan Dwinna Aliza Hamdan Hamdan |
| author_sort | T. Armansyah TR |
| collection | DOAJ |
| description | ABSTRACT The aim of this research was to asses the acute toxicity of ethanolic extract of malaka leaves using lethal dose 50 (LD50) on mice (Mus musculus). Twenty male mice weighing between 20-30 g were randomly divided into 4 groups (group K1-K4) of 5 mice each. All mice in group K1, K2, K3, and K4 were administered ethanolic extract of malaka leaves with the dose of 2, 4, 8, and 16 g/kg bw, respectively. Single dose of ethanolic extract of malaka leaves were given by oral gavage prior to clinical observation . The observation period was 14 days post administration, for sign of toxicity symptom, weight loss, and mortality. The result showed that no mortality was observed in the experimental animals during this study. Slight reduction of body weight was observed in group K2, K3, and K4, and no toxicity sign was found during fourteen days of observation. The LD50 of ethanolic extract of malaka leaves was higher than 16 g/kg body weight, thus, the substance was practically non toxic substance. |
| first_indexed | 2024-03-07T16:16:28Z |
| format | Article |
| id | doaj.art-04fc8b50195d4ddc99f42a0e1479db43 |
| institution | Directory Open Access Journal |
| issn | 1978-225X 2502-5600 |
| language | English |
| last_indexed | 2025-03-22T03:58:16Z |
| publishDate | 2016-09-01 |
| publisher | Universitas Syiah Kuala |
| record_format | Article |
| series | Jurnal Kedokteran Hewan |
| spelling | doaj.art-04fc8b50195d4ddc99f42a0e1479db432024-04-28T10:54:43ZengUniversitas Syiah KualaJurnal Kedokteran Hewan1978-225X2502-56002016-09-0110219219410.21157/j.ked.hewan.v10i2.51374305UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus))T. Armansyah TR0Sudi Indriany1Amalia Sutriana2Rosmaidar Rosmaidar3Nuzul AsmiliaBudianto PanjaitanDwinna Aliza4Hamdan Hamdan5Laboratorium Farmakologi Fakultas Kedokteran Universitas Syiah Kuala, Banda AcehProgram Studi Pendidikan Dokter Hewan Fakultas Kedokteran Hewan, Universitas Syiah Kuala, Banda AcehLaboratorium Farmakologi Fakultas Kedokteran Universitas Syiah Kuala, Banda AcehLaboratorium Farmakologi Fakultas Kedokteran Universitas Syiah Kuala, Banda AcehLaboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda AcehLaboratorium Reproduksi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda AcehABSTRACT The aim of this research was to asses the acute toxicity of ethanolic extract of malaka leaves using lethal dose 50 (LD50) on mice (Mus musculus). Twenty male mice weighing between 20-30 g were randomly divided into 4 groups (group K1-K4) of 5 mice each. All mice in group K1, K2, K3, and K4 were administered ethanolic extract of malaka leaves with the dose of 2, 4, 8, and 16 g/kg bw, respectively. Single dose of ethanolic extract of malaka leaves were given by oral gavage prior to clinical observation . The observation period was 14 days post administration, for sign of toxicity symptom, weight loss, and mortality. The result showed that no mortality was observed in the experimental animals during this study. Slight reduction of body weight was observed in group K2, K3, and K4, and no toxicity sign was found during fourteen days of observation. The LD50 of ethanolic extract of malaka leaves was higher than 16 g/kg body weight, thus, the substance was practically non toxic substance.https://jurnal.usk.ac.id/JKH/article/view/5137toxicity testethanolic extract of malaka leavesld50 |
| spellingShingle | T. Armansyah TR Sudi Indriany Amalia Sutriana Rosmaidar Rosmaidar Nuzul Asmilia Budianto Panjaitan Dwinna Aliza Hamdan Hamdan UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus)) Jurnal Kedokteran Hewan toxicity test ethanolic extract of malaka leaves ld50 |
| title | UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus)) |
| title_full | UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus)) |
| title_fullStr | UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus)) |
| title_full_unstemmed | UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus)) |
| title_short | UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MALAKA (Phyllantus emblica) TERHADAP MENCIT (Mus musculus). (Acute Toxicity Test of Ethanolic Extract of Malaka (Phyllantus emblica) Leaves on Mice (Mus musculus)) |
| title_sort | uji toksisitas akut ekstrak etanol daun malaka phyllantus emblica terhadap mencit mus musculus acute toxicity test of ethanolic extract of malaka phyllantus emblica leaves on mice mus musculus |
| topic | toxicity test ethanolic extract of malaka leaves ld50 |
| url | https://jurnal.usk.ac.id/JKH/article/view/5137 |
| work_keys_str_mv | AT tarmansyahtr ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT sudiindriany ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT amaliasutriana ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT rosmaidarrosmaidar ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT nuzulasmilia ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT budiantopanjaitan ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT dwinnaaliza ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus AT hamdanhamdan ujitoksisitasakutekstraketanoldaunmalakaphyllantusemblicaterhadapmencitmusmusculusacutetoxicitytestofethanolicextractofmalakaphyllantusemblicaleavesonmicemusmusculus |