Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis
Introduction Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, how brain connectivity changes with methylphenidate treatment have yet to be studied. Objectives...
| Những tác giả chính: | , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
| Được phát hành: |
Cambridge University Press
2021-04-01
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| Loạt: | European Psychiatry |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://www.cambridge.org/core/product/identifier/S0924933821016862/type/journal_article |
| Tóm tắt: | Introduction
Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, how brain connectivity changes with methylphenidate treatment have yet to be studied.
Objectives
This study investigates how the MPH treatment affects the connectivity in the brain of children with ADHD by coherence-based qEEG analysis during rest.
Methods
During eyes-open resting, EEG signals were recorded from 25 boys with ADHD-combined type before MPH administration and at the end of the 1st month of the treatment. Mutual Information (MI),Coherence Function (COH) and Phase Locking Value (PLV) were used to analyse the changes in brain connectivity.
Results
A statistically significant increase in connectivity level was found with MPH treatment between the F3-F4 channels, P3-P4 channels, F7-F8 channels and T5-T6 channels according to PLV, COH and MI analysis (p<0.001).
Conclusions
This is the first study to investigate how MPH treatment affects the connectivity of the brain of children with ADHD. Coherence-based qEEG analysis may be a new method that can be used in diagnostic, clinical and prognostic predictions in ADHD.
Disclosure
No significant relationships.
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| số ISSN: | 0924-9338 1778-3585 |