Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis
Introduction Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, how brain connectivity changes with methylphenidate treatment have yet to be studied. Objectives...
| প্রধান লেখক: | , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Cambridge University Press
2021-04-01
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| মালা: | European Psychiatry |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.cambridge.org/core/product/identifier/S0924933821016862/type/journal_article |
| _version_ | 1827754422626680832 |
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| author | F.H. Çetin Ş. Gıca M. Çıkılı Uytun Z. Babadağı M.B. Usta A.S. Güven Y. Işık |
| author_facet | F.H. Çetin Ş. Gıca M. Çıkılı Uytun Z. Babadağı M.B. Usta A.S. Güven Y. Işık |
| author_sort | F.H. Çetin |
| collection | DOAJ |
| description |
Introduction
Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, how brain connectivity changes with methylphenidate treatment have yet to be studied.
Objectives
This study investigates how the MPH treatment affects the connectivity in the brain of children with ADHD by coherence-based qEEG analysis during rest.
Methods
During eyes-open resting, EEG signals were recorded from 25 boys with ADHD-combined type before MPH administration and at the end of the 1st month of the treatment. Mutual Information (MI),Coherence Function (COH) and Phase Locking Value (PLV) were used to analyse the changes in brain connectivity.
Results
A statistically significant increase in connectivity level was found with MPH treatment between the F3-F4 channels, P3-P4 channels, F7-F8 channels and T5-T6 channels according to PLV, COH and MI analysis (p<0.001).
Conclusions
This is the first study to investigate how MPH treatment affects the connectivity of the brain of children with ADHD. Coherence-based qEEG analysis may be a new method that can be used in diagnostic, clinical and prognostic predictions in ADHD.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:48:53Z |
| format | Article |
| id | doaj.art-04fd1444e3c1411a860328b30b51a29e |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:48:53Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-04fd1444e3c1411a860328b30b51a29e2023-11-17T05:06:58ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S634S63510.1192/j.eurpsy.2021.1686Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysisF.H. Çetin0Ş. Gıca1M. Çıkılı Uytun2Z. Babadağı3M.B. Usta4A.S. Güven5Y. Işık6Child And Adolescent Psychiatry, Selcuk University, Faculty of Medicine, Konya, TurkeyPsychiatry, Necmettin Erbakan Univesity, Meram Faculty of Medicine, Konya, TurkeyChild And Adolescent Psychiatry, Ankara University, Faculty of Medicine, Ankara, TurkeyChild And Adolescent Psychiatry, Kayseri City Hospital, Kayseri, TurkeyChild And Adolescent Psychiatry, Ondokuz Mayıs University, Faculty of Medicine, Samsun, TurkeyPediatric Neurology, Necmettin Erbakan Univesity, Meram Faculty of Medicine, Konya, TurkeyChild And Adolescent Psychiatry, Gazi University, Faculty of Medicine, Ankara, Turkey Introduction Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, how brain connectivity changes with methylphenidate treatment have yet to be studied. Objectives This study investigates how the MPH treatment affects the connectivity in the brain of children with ADHD by coherence-based qEEG analysis during rest. Methods During eyes-open resting, EEG signals were recorded from 25 boys with ADHD-combined type before MPH administration and at the end of the 1st month of the treatment. Mutual Information (MI),Coherence Function (COH) and Phase Locking Value (PLV) were used to analyse the changes in brain connectivity. Results A statistically significant increase in connectivity level was found with MPH treatment between the F3-F4 channels, P3-P4 channels, F7-F8 channels and T5-T6 channels according to PLV, COH and MI analysis (p<0.001). Conclusions This is the first study to investigate how MPH treatment affects the connectivity of the brain of children with ADHD. Coherence-based qEEG analysis may be a new method that can be used in diagnostic, clinical and prognostic predictions in ADHD. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821016862/type/journal_articleADHDmethylphenidateqEEGconnectivity |
| spellingShingle | F.H. Çetin Ş. Gıca M. Çıkılı Uytun Z. Babadağı M.B. Usta A.S. Güven Y. Işık Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis European Psychiatry ADHD methylphenidate qEEG connectivity |
| title | Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis |
| title_full | Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis |
| title_fullStr | Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis |
| title_full_unstemmed | Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis |
| title_short | Increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder: A coherence-based qeeg analysis |
| title_sort | increase in brain connectivity with methylphenidate treatment in boys diagnosed with attention deficit hyperactivity disorder a coherence based qeeg analysis |
| topic | ADHD methylphenidate qEEG connectivity |
| url | https://www.cambridge.org/core/product/identifier/S0924933821016862/type/journal_article |
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