Serial five-membered lactone ring ions in the treatment of Alzheimer’s diseases-comprehensive profiling of arctigenin metabolites and network analysis

Serial five-membered lactone ring ions in the treatment of Alzheimer’s diseases-comprehensive profiling of arctigenin metabolites and network analysis

Arctigenin is a phenylpropanoid dibenzylbutyro lactone lignan compound with multiple biological functions. Previous studies have shown that arctigenin have neuroprotective effects in Alzheimer’s disease (AD) models both in vivo and in vitro; however, its metabolism in vivo has not been studied. Most...

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Bibliographic Details
Main Authors:	Yanan Li, Xianming Lan, Shaoping Wang, Yifang Cui, Shuyi Song, Hongyan Zhou, Qiyan Li, Long Dai, Jiayu Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Pharmacology
Subjects:	arctigenin five-membered lactone ring ions fishing strategy metabolism Alzheimer’s diseases network pharmacology UHPLC-Q-exactive orbitrap mass spectrometer
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1065654/full

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