Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
Sarcopenic obesity, low muscle mass, and high body fat are growing health concerns in the aging population. This review highlights the need for standardized criteria and explores nutraceuticals as potential therapeutic agents. Sarcopenic obesity is associated with insulin resistance, inflammation, h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/17/3854 |
| _version_ | 1797582024770322432 |
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| author | Young-Chan Kim Sang-Woo Ki Hannah Kim Sumin Kang Hayoon Kim Gwang-woong Go |
| author_facet | Young-Chan Kim Sang-Woo Ki Hannah Kim Sumin Kang Hayoon Kim Gwang-woong Go |
| author_sort | Young-Chan Kim |
| collection | DOAJ |
| description | Sarcopenic obesity, low muscle mass, and high body fat are growing health concerns in the aging population. This review highlights the need for standardized criteria and explores nutraceuticals as potential therapeutic agents. Sarcopenic obesity is associated with insulin resistance, inflammation, hormonal changes, and reduced physical activity. These factors lead to impaired muscle activity, intramuscular fat accumulation, and reduced protein synthesis, resulting in muscle catabolism and increased fat mass. Myostatin and irisin are myokines that regulate muscle synthesis and energy expenditure, respectively. Nutritional supplementation with vitamin D and calcium is recommended for increasing muscle mass and reducing body fat content. Testosterone therapy decreases fat mass and improves muscle strength. Vitamin K, specifically menaquinone-4 (MK-4), improves mitochondrial function and reduces muscle damage. Irisin is a hormone secreted during exercise that enhances oxidative metabolism, prevents insulin resistance and obesity, and improves bone quality. Low-glycemic-index diets and green cardamom are potential methods for managing sarcopenic obesity. In conclusion, along with exercise and dietary support, nutraceuticals, such as vitamin D, calcium, vitamin K, and natural agonists of irisin or testosterone, can serve as promising future therapeutic alternatives. |
| first_indexed | 2024-03-10T23:14:58Z |
| format | Article |
| id | doaj.art-04fe0e52dc404abfacd05e6eba170ce4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:14:58Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-04fe0e52dc404abfacd05e6eba170ce42023-11-19T08:40:04ZengMDPI AGNutrients2072-66432023-09-011517385410.3390/nu15173854Recent Advances in Nutraceuticals for the Treatment of Sarcopenic ObesityYoung-Chan Kim0Sang-Woo Ki1Hannah Kim2Sumin Kang3Hayoon Kim4Gwang-woong Go5Department of Food and Nutrition, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Food and Nutrition, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Food and Nutrition, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Food and Nutrition, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Food and Nutrition, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Food and Nutrition, Hanyang University, Seoul 04763, Republic of KoreaSarcopenic obesity, low muscle mass, and high body fat are growing health concerns in the aging population. This review highlights the need for standardized criteria and explores nutraceuticals as potential therapeutic agents. Sarcopenic obesity is associated with insulin resistance, inflammation, hormonal changes, and reduced physical activity. These factors lead to impaired muscle activity, intramuscular fat accumulation, and reduced protein synthesis, resulting in muscle catabolism and increased fat mass. Myostatin and irisin are myokines that regulate muscle synthesis and energy expenditure, respectively. Nutritional supplementation with vitamin D and calcium is recommended for increasing muscle mass and reducing body fat content. Testosterone therapy decreases fat mass and improves muscle strength. Vitamin K, specifically menaquinone-4 (MK-4), improves mitochondrial function and reduces muscle damage. Irisin is a hormone secreted during exercise that enhances oxidative metabolism, prevents insulin resistance and obesity, and improves bone quality. Low-glycemic-index diets and green cardamom are potential methods for managing sarcopenic obesity. In conclusion, along with exercise and dietary support, nutraceuticals, such as vitamin D, calcium, vitamin K, and natural agonists of irisin or testosterone, can serve as promising future therapeutic alternatives.https://www.mdpi.com/2072-6643/15/17/3854irisinmitochondrial functionnutraceuticalsarcopenic obesity |
| spellingShingle | Young-Chan Kim Sang-Woo Ki Hannah Kim Sumin Kang Hayoon Kim Gwang-woong Go Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity Nutrients irisin mitochondrial function nutraceutical sarcopenic obesity |
| title | Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity |
| title_full | Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity |
| title_fullStr | Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity |
| title_full_unstemmed | Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity |
| title_short | Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity |
| title_sort | recent advances in nutraceuticals for the treatment of sarcopenic obesity |
| topic | irisin mitochondrial function nutraceutical sarcopenic obesity |
| url | https://www.mdpi.com/2072-6643/15/17/3854 |
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