Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging.
To develop magnetic resonance imaging (MRI) indicators to predict trismus outcome for post-operative oral cavity cancer patients who received adjuvant intensity-modulated radiation therapy (IMRT), 22 patients with oral cancer treated with IMRT were studied over a two-year period. Signal abnormality...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3962418?pdf=render |
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| author | Li-Chun Hsieh John W Chen Li-Ying Wang Yuk-Ming Tsang Pei-Wei Shueng Li-Jen Liao Wu-Chia Lo Yu-Chin Lin Chien-Fu Tseng Ying-Shiung Kuo Jie-Yang Jhuang Hui-Ju Tien Hsueh-Fen Juan Chen-Hsi Hsieh |
| author_facet | Li-Chun Hsieh John W Chen Li-Ying Wang Yuk-Ming Tsang Pei-Wei Shueng Li-Jen Liao Wu-Chia Lo Yu-Chin Lin Chien-Fu Tseng Ying-Shiung Kuo Jie-Yang Jhuang Hui-Ju Tien Hsueh-Fen Juan Chen-Hsi Hsieh |
| author_sort | Li-Chun Hsieh |
| collection | DOAJ |
| description | To develop magnetic resonance imaging (MRI) indicators to predict trismus outcome for post-operative oral cavity cancer patients who received adjuvant intensity-modulated radiation therapy (IMRT), 22 patients with oral cancer treated with IMRT were studied over a two-year period. Signal abnormality scores (SA scores) were computed from Likert-type ratings of the abnormalities of nine masticator structures and compared with the Mann-Whitney U-test and Kruskal-Wallis one-way ANOVA test between groups. Seventeen patients (77.3%) experienced different degrees of trismus during the two-year follow-up period. The SA score correlated with the trismus grade (r = 0.52, p<0.005). Patients having progressive trismus had higher mean doses of radiation to multiple structures, including the masticator and lateral pterygoid muscles, and the parotid gland (p<0.05). In addition, this group also had higher SA-masticator muscle dose product at 6 months and SA scores at 12 months (p<0.05). At the optimum cut-off points of 0.38 for the propensity score, the sensitivity was 100% and the specificity was 93% for predicting the prognosis of the trismus patients. The SA score, as determined using MRI, can reflect the radiation injury and correlate to trismus severity. Together with the radiation dose, it could serve as a useful biomarker to predict the outcome and guide the management of trismus following radiation therapy. |
| first_indexed | 2024-12-13T09:28:51Z |
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| id | doaj.art-04fe2de728a34f4a9cfb01d4c0a042f3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:28:51Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-04fe2de728a34f4a9cfb01d4c0a042f32022-12-21T23:52:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9256110.1371/journal.pone.0092561Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging.Li-Chun HsiehJohn W ChenLi-Ying WangYuk-Ming TsangPei-Wei ShuengLi-Jen LiaoWu-Chia LoYu-Chin LinChien-Fu TsengYing-Shiung KuoJie-Yang JhuangHui-Ju TienHsueh-Fen JuanChen-Hsi HsiehTo develop magnetic resonance imaging (MRI) indicators to predict trismus outcome for post-operative oral cavity cancer patients who received adjuvant intensity-modulated radiation therapy (IMRT), 22 patients with oral cancer treated with IMRT were studied over a two-year period. Signal abnormality scores (SA scores) were computed from Likert-type ratings of the abnormalities of nine masticator structures and compared with the Mann-Whitney U-test and Kruskal-Wallis one-way ANOVA test between groups. Seventeen patients (77.3%) experienced different degrees of trismus during the two-year follow-up period. The SA score correlated with the trismus grade (r = 0.52, p<0.005). Patients having progressive trismus had higher mean doses of radiation to multiple structures, including the masticator and lateral pterygoid muscles, and the parotid gland (p<0.05). In addition, this group also had higher SA-masticator muscle dose product at 6 months and SA scores at 12 months (p<0.05). At the optimum cut-off points of 0.38 for the propensity score, the sensitivity was 100% and the specificity was 93% for predicting the prognosis of the trismus patients. The SA score, as determined using MRI, can reflect the radiation injury and correlate to trismus severity. Together with the radiation dose, it could serve as a useful biomarker to predict the outcome and guide the management of trismus following radiation therapy.http://europepmc.org/articles/PMC3962418?pdf=render |
| spellingShingle | Li-Chun Hsieh John W Chen Li-Ying Wang Yuk-Ming Tsang Pei-Wei Shueng Li-Jen Liao Wu-Chia Lo Yu-Chin Lin Chien-Fu Tseng Ying-Shiung Kuo Jie-Yang Jhuang Hui-Ju Tien Hsueh-Fen Juan Chen-Hsi Hsieh Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. PLoS ONE |
| title | Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. |
| title_full | Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. |
| title_fullStr | Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. |
| title_full_unstemmed | Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. |
| title_short | Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. |
| title_sort | predicting the severity and prognosis of trismus after intensity modulated radiation therapy for oral cancer patients by magnetic resonance imaging |
| url | http://europepmc.org/articles/PMC3962418?pdf=render |
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