Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms
Obesity is a major burden for modern medicine, with many links to negative health outcomes, including the increased incidence of certain cancer types. Interestingly, some studies have supported the concept of an “Obesity Paradox”, where some cancer patients living with obesity have been shown to hav...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/11/1150 |
| _version_ | 1797464533170651136 |
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| author | Xiaoyang Lan Nicola Fazio Omar Abdel-Rahman |
| author_facet | Xiaoyang Lan Nicola Fazio Omar Abdel-Rahman |
| author_sort | Xiaoyang Lan |
| collection | DOAJ |
| description | Obesity is a major burden for modern medicine, with many links to negative health outcomes, including the increased incidence of certain cancer types. Interestingly, some studies have supported the concept of an “Obesity Paradox”, where some cancer patients living with obesity have been shown to have a better prognosis than non-obese patients. Neuroendocrine neoplasms (NENs) are malignancies originating from neuroendocrine cells, in some cases retaining important functional properties with consequences for metabolism and nutritional status. In this review, we summarize the existing evidence demonstrating that obesity is both a risk factor for developing NENs as well as a good prognostic factor. We further identify the limitations of existing studies and further avenues of research that will be necessary to optimize the metabolic and nutritional status of patients living with NENs to ensure improved outcomes. |
| first_indexed | 2024-03-09T18:08:32Z |
| format | Article |
| id | doaj.art-04fea90678bf4b1d86dca30bdf7a30a8 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T18:08:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-04fea90678bf4b1d86dca30bdf7a30a82023-11-24T09:13:52ZengMDPI AGMetabolites2218-19892022-11-011211115010.3390/metabo12111150Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine NeoplasmsXiaoyang Lan0Nicola Fazio1Omar Abdel-Rahman2Department of Medicine, University of Alberta, Edmonton, AB T6G 1Z2, CanadaDivision of Gastrointestinal Medical Oncology, European Institute of Oncology (Istituto Europeo di Oncologia—IEO), Istituto di Ricovero e Cura a Carattere Scientifico—IRCCS, 20141 Milan, ItalyDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, CanadaObesity is a major burden for modern medicine, with many links to negative health outcomes, including the increased incidence of certain cancer types. Interestingly, some studies have supported the concept of an “Obesity Paradox”, where some cancer patients living with obesity have been shown to have a better prognosis than non-obese patients. Neuroendocrine neoplasms (NENs) are malignancies originating from neuroendocrine cells, in some cases retaining important functional properties with consequences for metabolism and nutritional status. In this review, we summarize the existing evidence demonstrating that obesity is both a risk factor for developing NENs as well as a good prognostic factor. We further identify the limitations of existing studies and further avenues of research that will be necessary to optimize the metabolic and nutritional status of patients living with NENs to ensure improved outcomes.https://www.mdpi.com/2218-1989/12/11/1150obesityneuroendocrine neoplasmbody mass indexnutrition |
| spellingShingle | Xiaoyang Lan Nicola Fazio Omar Abdel-Rahman Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms Metabolites obesity neuroendocrine neoplasm body mass index nutrition |
| title | Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms |
| title_full | Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms |
| title_fullStr | Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms |
| title_full_unstemmed | Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms |
| title_short | Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms |
| title_sort | exploring the relationship between obesity metabolic syndrome and neuroendocrine neoplasms |
| topic | obesity neuroendocrine neoplasm body mass index nutrition |
| url | https://www.mdpi.com/2218-1989/12/11/1150 |
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