Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway

Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway

Abstract Introduction Previous evidence realized the critical role of histone in disease control. The anti‐inflammatory function of estradiol (E2) in sepsis has been documented. We here intended to unveil the role of extracellular histone H3 in sepsis regarding cell ferroptosis and the role of E2 in...

Full description

Bibliographic Details
Main Authors:	Zhijun Han, Zhizhou Yuan, Linfei Shu, Tao Li, Fan Yang, Lei Chen
Format:	Article
Language:	English
Published:	Wiley 2023-01-01
Series:	Immunity, Inflammation and Disease
Subjects:	c‐Jun N‐terminal kinase estradiol ferroptosis histones H3 reactive oxygen species sepsis
Online Access:	https://doi.org/10.1002/iid3.754

Similar Items

L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells
by: Weijia Peng, et al.
Published: (2022-03-01)

Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death
by: Sanda Win, et al.
Published: (2024-03-01)

Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway
by: So Young Kim, et al.
Published: (2020-07-01)

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons
by: Zhengyu Cao, et al.
Published: (2015-02-01)

Effects of lead and manganese combined exposure on neurodevelopmental toxicity and JNK expression in zebrafish
by: Yuan XIA, et al.
Published: (2023-05-01)

JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model
by: Erica Cecilia Priori, et al.
Published: (2023-03-01)

JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the Drosophila testis
by: Salvador C Herrera, et al.
Published: (2018-07-01)

The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma
by: Zehui Li, et al.
Published: (2019-01-01)

Combination Therapy with a JNK Inhibitor and Hepatocyte Growth Factor for Restoration of Erectile Function in a Rat Model of Cavernosal Nerve Injury: Comparison with a JNK Inhibitor Alone or Hepatocyte Growth Factor Alone
by: Junghoon Lee, et al.
Published: (2021-11-01)

The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4
by: Tobias F. Primke, et al.
Published: (2023-08-01)

Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis
by: Junji Shimizu, et al.
Published: (2022-06-01)

Recombinant Extracellular Domain (p75ECD) of the Neurotrophin Receptor p75 Attenuates Myocardial Ischemia–Reperfusion Injury by Inhibiting the p‐JNK/Caspase‐3 Signaling Pathway in Rat Microvascular Pericytes
by: Jun Fang, et al.
Published: (2020-07-01)

FGF‐2 suppresses expression of nephronectin via JNK and PI3K pathways
by: Tadashi Kato, et al.
Published: (2018-05-01)

Microcystin-LR accelerates follicular atresia in mice via JNK-mediated adherent junction damage of ovarian granulosa cells
by: Xingde Du, et al.
Published: (2023-03-01)

Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study
by: Wu L, et al.
Published: (2019-08-01)

Roles of the MST1-JNK signaling pathway in apoptosis of colorectal cancer cells induced by Taurine
by: Zhuoqi Liu, et al.
Published: (2018-01-01)

Terpinen-4-ol Induces Ferroptosis of Glioma Cells via Downregulating JUN Proto-Oncogene
by: Wenpeng Cao, et al.
Published: (2023-06-01)

JNK Signaling in Stem Cell Self-Renewal and Differentiation
by: Takashi Semba, et al.
Published: (2020-04-01)

Characterization and role exploration of ferroptosis-related genes in osteoarthritis
by: Xinyu Wang, et al.
Published: (2023-03-01)

Screening of potential key ferroptosis-related genes in sepsis
by: Shunan Cui, et al.
Published: (2022-09-01)

Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis
by: Benjamin Lai, et al.
Published: (2020-11-01)

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade
by: Manuel Canedo-Antelo, et al.
Published: (2018-09-01)

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
by: Lesley Jia Wei Pua, et al.
Published: (2022-01-01)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
by: Justin Hou Ming Yung, et al.
Published: (2020-03-01)

The Emerging Role of Ferroptosis in Sepsis, Opportunity or Challenge?
by: Huang Q, et al.
Published: (2023-08-01)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
by: Nina D. Anfinogenova, et al.
Published: (2020-10-01)

Targeting novel regulated cell death：Ferroptosis, pyroptosis, and autophagy in sepsis-associated encephalopathy
by: Jingjing Sun, et al.
Published: (2024-05-01)

Metformin Inducing the Change of Functional and Exhausted Phenotypic Tumor-Infiltrated Lymphocytes and the Correlation with JNK Signal Pathway in Triple-Negative Breast Cancer
by: Wang R, et al.
Published: (2022-12-01)

Effects of Metformin on JNK Signaling Pathway and PD-L1 Expression in Triple Negative Breast Cancer
by: Wang R, et al.
Published: (2024-04-01)

JNK inhibitor IX restrains pancreatic cancer through p53 and p21
by: Jingwei Shi, et al.
Published: (2022-12-01)

Identification of Molecular Subtypes and a Novel Prognostic Model of Sepsis Based on Ferroptosis-Associated Gene Signature
by: Hang Yang, et al.
Published: (2022-10-01)

Diagnostic and Predictive Values of Ferroptosis-Related Genes in Child Sepsis
by: Zhi Li, et al.
Published: (2022-06-01)

Novel Tryptanthrin Derivatives with Selectivity as <i>c</i>–Jun N–Terminal Kinase (JNK) 3 Inhibitors
by: Igor A. Schepetkin, et al.
Published: (2023-06-01)

20(S)-ginsenoside Rh2 inhibits angiotensin-2 mediated cardiac remodeling and inflammation associated with suppression of the JNK/AP-1 pathway
by: Tianxiang Yu, et al.
Published: (2023-12-01)

Identification of ferroptosis-associated genes and potential pharmacological targets in sepsis-induced myopathy
by: Dongfang Wang, et al.
Published: (2024-04-01)

Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway
by: Ching-Yao Yang, et al.
Published: (2022-03-01)

Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells
by: Phuong Linh Nguyen, et al.
Published: (2021-08-01)

Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators
by: Béatrice Benoit, et al.
Published: (2021-08-01)

Ferroptosis in sepsis: The mechanism, the role and the therapeutic potential
by: Lei XL, et al.
Published: (2022-08-01)

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection
by: Yuhan Chang, et al.
Published: (2020-04-01)