Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study
BackgroundPeople living with HIV (PLWHA) smoke at three times the rate of the general population and respond poorly to cessation strategies. Previous studies examined repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (L. dlPFC) to reduce craving, but no stu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1315854/full |
| _version_ | 1797278810957152256 |
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| author | Gopalkumar Rakesh Thomas G. Adams Rajendra A. Morey Joseph L. Alcorn Rebika Khanal Amanda E. Su Seth S. Himelhoch Craig R. Rush |
| author_facet | Gopalkumar Rakesh Thomas G. Adams Rajendra A. Morey Joseph L. Alcorn Rebika Khanal Amanda E. Su Seth S. Himelhoch Craig R. Rush |
| author_sort | Gopalkumar Rakesh |
| collection | DOAJ |
| description | BackgroundPeople living with HIV (PLWHA) smoke at three times the rate of the general population and respond poorly to cessation strategies. Previous studies examined repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (L. dlPFC) to reduce craving, but no studies have explored rTMS among PLWHA who smoke. The current pilot study compared the effects of active and sham intermittent theta-burst stimulation (iTBS) on resting state functional connectivity (rsFC), cigarette cue attentional bias, and cigarette craving in PLWHA who smoke.MethodsEight PLWHA were recruited (single-blind, within-subject design) to receive one session of iTBS (n=8) over the L. dlPFC using neuronavigation and, four weeks later, sham iTBS (n=5). Cigarette craving and attentional bias assessments were completed before and after both iTBS and sham iTBS. rsFC was assessed before iTBS (baseline) and after iTBS and sham iTBS.ResultsCompared to sham iTBS, iTBS enhanced rsFC between the L. dlPFC and bilateral medial prefrontal cortex and pons. iTBS also enhanced rsFC between the right insula and right occipital cortex compared to sham iTBS. iTBS also decreased cigarette craving and cigarette cue attentional bias.ConclusioniTBS could potentially offer a therapeutic option for smoking cessation in PLWHA. |
| first_indexed | 2024-03-07T16:15:30Z |
| format | Article |
| id | doaj.art-0500cf1bdfaf44f7b75e83571b7a91aa |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-07T16:15:30Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-0500cf1bdfaf44f7b75e83571b7a91aa2024-03-04T11:09:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-03-011510.3389/fpsyt.2024.13158541315854Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot studyGopalkumar Rakesh0Thomas G. Adams1Rajendra A. Morey2Joseph L. Alcorn3Rebika Khanal4Amanda E. Su5Seth S. Himelhoch6Craig R. Rush7Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Psychology, College of Arts & Sciences, University of Kentucky, Lexington, KY, United StatesBrain Imaging and Analyses Center (BIAC), Duke University Medical Center, Durham, NC, United StatesDepartment of Behavioral Sciences, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United StatesDepartment of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Behavioral Sciences, College of Medicine, University of Kentucky, Lexington, KY, United StatesBackgroundPeople living with HIV (PLWHA) smoke at three times the rate of the general population and respond poorly to cessation strategies. Previous studies examined repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (L. dlPFC) to reduce craving, but no studies have explored rTMS among PLWHA who smoke. The current pilot study compared the effects of active and sham intermittent theta-burst stimulation (iTBS) on resting state functional connectivity (rsFC), cigarette cue attentional bias, and cigarette craving in PLWHA who smoke.MethodsEight PLWHA were recruited (single-blind, within-subject design) to receive one session of iTBS (n=8) over the L. dlPFC using neuronavigation and, four weeks later, sham iTBS (n=5). Cigarette craving and attentional bias assessments were completed before and after both iTBS and sham iTBS. rsFC was assessed before iTBS (baseline) and after iTBS and sham iTBS.ResultsCompared to sham iTBS, iTBS enhanced rsFC between the L. dlPFC and bilateral medial prefrontal cortex and pons. iTBS also enhanced rsFC between the right insula and right occipital cortex compared to sham iTBS. iTBS also decreased cigarette craving and cigarette cue attentional bias.ConclusioniTBS could potentially offer a therapeutic option for smoking cessation in PLWHA.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1315854/fullrTMShiv/aidssmokingcessationcigarette cue attentional biasfMRI |
| spellingShingle | Gopalkumar Rakesh Thomas G. Adams Rajendra A. Morey Joseph L. Alcorn Rebika Khanal Amanda E. Su Seth S. Himelhoch Craig R. Rush Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study Frontiers in Psychiatry rTMS hiv/aids smoking cessation cigarette cue attentional bias fMRI |
| title | Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study |
| title_full | Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study |
| title_fullStr | Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study |
| title_full_unstemmed | Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study |
| title_short | Intermittent theta burst stimulation and functional connectivity in people living with HIV/AIDS who smoke tobacco cigarettes: a preliminary pilot study |
| title_sort | intermittent theta burst stimulation and functional connectivity in people living with hiv aids who smoke tobacco cigarettes a preliminary pilot study |
| topic | rTMS hiv/aids smoking cessation cigarette cue attentional bias fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1315854/full |
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