Activation of the GABA-alpha receptor by berberine rescues retinal ganglion cells to attenuate experimental diabetic retinopathy

Activation of the GABA-alpha receptor by berberine rescues retinal ganglion cells to attenuate experimental diabetic retinopathy

PurposeThe aim of this study was to investigate the role and mechanism of berberine (BBR) in the protection of injured retinal ganglion cells (RGCs) in diabetic retinopathy (DR).MethodsExperimental diabetic retinopathy rat model was successfully induced by a single intraperitoneal injection of strep...

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Bibliographic Details
Main Authors: Wangyi Fang, Xiaojing Huang, Kaicheng Wu, Yuan Zong, Jian Yu, Huan Xu, Jiemei Shi, Jiaojiao Wei, Xujiao Zhou, Chunhui Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
diabetic retinopathy
GABA receptor
berberine
retinal ganglion cell
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.930599/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.930599/full

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