Connections between the Cell Cycle and the DNA Damage Response in Plants
Due to their sessile lifestyle, plants are especially exposed to various stresses, including genotoxic stress, which results in altered genome integrity. Upon the detection of DNA damage, distinct cellular responses lead to cell cycle arrest and the induction of DNA repair mechanisms. Interestingly,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9558 |
| _version_ | 1797521212238200832 |
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| author | Naomie Gentric Pascal Genschik Sandra Noir |
| author_facet | Naomie Gentric Pascal Genschik Sandra Noir |
| author_sort | Naomie Gentric |
| collection | DOAJ |
| description | Due to their sessile lifestyle, plants are especially exposed to various stresses, including genotoxic stress, which results in altered genome integrity. Upon the detection of DNA damage, distinct cellular responses lead to cell cycle arrest and the induction of DNA repair mechanisms. Interestingly, it has been shown that some cell cycle regulators are not only required for meristem activity and plant development but are also key to cope with the occurrence of DNA lesions. In this review, we first summarize some important regulatory steps of the plant cell cycle and present a brief overview of the DNA damage response (DDR) mechanisms. Then, the role played by some cell cycle regulators at the interface between the cell cycle and DNA damage responses is discussed more specifically. |
| first_indexed | 2024-03-10T08:09:24Z |
| format | Article |
| id | doaj.art-05035ec87b12466e808fe3492d0c85a4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:09:24Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-05035ec87b12466e808fe3492d0c85a42023-11-22T10:45:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-012217955810.3390/ijms22179558Connections between the Cell Cycle and the DNA Damage Response in PlantsNaomie Gentric0Pascal Genschik1Sandra Noir2Institut de Biologie Moléculaire des Plantes–CNRS, Université de Strasbourg, 12 Rue du Général Zimmer, 67084 Strasbourg, FranceInstitut de Biologie Moléculaire des Plantes–CNRS, Université de Strasbourg, 12 Rue du Général Zimmer, 67084 Strasbourg, FranceInstitut de Biologie Moléculaire des Plantes–CNRS, Université de Strasbourg, 12 Rue du Général Zimmer, 67084 Strasbourg, FranceDue to their sessile lifestyle, plants are especially exposed to various stresses, including genotoxic stress, which results in altered genome integrity. Upon the detection of DNA damage, distinct cellular responses lead to cell cycle arrest and the induction of DNA repair mechanisms. Interestingly, it has been shown that some cell cycle regulators are not only required for meristem activity and plant development but are also key to cope with the occurrence of DNA lesions. In this review, we first summarize some important regulatory steps of the plant cell cycle and present a brief overview of the DNA damage response (DDR) mechanisms. Then, the role played by some cell cycle regulators at the interface between the cell cycle and DNA damage responses is discussed more specifically.https://www.mdpi.com/1422-0067/22/17/9558DNA damage responseplant cell cycle |
| spellingShingle | Naomie Gentric Pascal Genschik Sandra Noir Connections between the Cell Cycle and the DNA Damage Response in Plants International Journal of Molecular Sciences DNA damage response plant cell cycle |
| title | Connections between the Cell Cycle and the DNA Damage Response in Plants |
| title_full | Connections between the Cell Cycle and the DNA Damage Response in Plants |
| title_fullStr | Connections between the Cell Cycle and the DNA Damage Response in Plants |
| title_full_unstemmed | Connections between the Cell Cycle and the DNA Damage Response in Plants |
| title_short | Connections between the Cell Cycle and the DNA Damage Response in Plants |
| title_sort | connections between the cell cycle and the dna damage response in plants |
| topic | DNA damage response plant cell cycle |
| url | https://www.mdpi.com/1422-0067/22/17/9558 |
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