Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.
Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown potent...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2641005?pdf=render |
| _version_ | 1811309902032797696 |
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| author | Moonsup Jeong Yong-Sam Kwon Soon-Hye Park Chae-Young Kim Sin-Soo Jeun Kang-Won Song Yong Ko Paul D Robbins Timothy R Billiar Byong-Moon Kim Dai-Wu Seol |
| author_facet | Moonsup Jeong Yong-Sam Kwon Soon-Hye Park Chae-Young Kim Sin-Soo Jeun Kang-Won Song Yong Ko Paul D Robbins Timothy R Billiar Byong-Moon Kim Dai-Wu Seol |
| author_sort | Moonsup Jeong |
| collection | DOAJ |
| description | Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancers, but concerns over delivery and toxicity have limited progress. We have developed a secretable trimeric TRAIL (stTRAIL) and here evaluated the therapeutic potential of this stTRAIL-based gene therapy in brain tumors. An adenovirus (Ad-stTRAIL) delivering stTRAIL was injected into intra-cranial human glioma tumors established in nude mice and tumor growth monitored using the magnetic resonance imaging (MRI). Ad-stTRAIL gene therapy showed potent tumor suppressor activity with no toxic side effects at therapeutically effective doses. When compared with 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a conventional therapy for malignant gliomas, Ad-stTRAIL suppressed tumor growth more potently. The combination of Ad-stTRAIL and BCNU significantly increased survival compared to the control mice or mice receiving Ad-stTRAIL alone. Our data indicate that Ad-stTRAIL, either alone or combined with BCNU, has promise as a novel therapy for malignant gliomas. |
| first_indexed | 2024-04-13T09:49:05Z |
| format | Article |
| id | doaj.art-050373e73bf24b4294768029654dbafa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T09:49:05Z |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-050373e73bf24b4294768029654dbafa2022-12-22T02:51:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0142e454510.1371/journal.pone.0004545Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.Moonsup JeongYong-Sam KwonSoon-Hye ParkChae-Young KimSin-Soo JeunKang-Won SongYong KoPaul D RobbinsTimothy R BilliarByong-Moon KimDai-Wu SeolMalignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancers, but concerns over delivery and toxicity have limited progress. We have developed a secretable trimeric TRAIL (stTRAIL) and here evaluated the therapeutic potential of this stTRAIL-based gene therapy in brain tumors. An adenovirus (Ad-stTRAIL) delivering stTRAIL was injected into intra-cranial human glioma tumors established in nude mice and tumor growth monitored using the magnetic resonance imaging (MRI). Ad-stTRAIL gene therapy showed potent tumor suppressor activity with no toxic side effects at therapeutically effective doses. When compared with 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a conventional therapy for malignant gliomas, Ad-stTRAIL suppressed tumor growth more potently. The combination of Ad-stTRAIL and BCNU significantly increased survival compared to the control mice or mice receiving Ad-stTRAIL alone. Our data indicate that Ad-stTRAIL, either alone or combined with BCNU, has promise as a novel therapy for malignant gliomas.http://europepmc.org/articles/PMC2641005?pdf=render |
| spellingShingle | Moonsup Jeong Yong-Sam Kwon Soon-Hye Park Chae-Young Kim Sin-Soo Jeun Kang-Won Song Yong Ko Paul D Robbins Timothy R Billiar Byong-Moon Kim Dai-Wu Seol Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS ONE |
| title | Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. |
| title_full | Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. |
| title_fullStr | Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. |
| title_full_unstemmed | Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. |
| title_short | Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. |
| title_sort | possible novel therapy for malignant gliomas with secretable trimeric trail |
| url | http://europepmc.org/articles/PMC2641005?pdf=render |
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