Posttesticular sperm maturation, infertility, and hypercholesterolemia
Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol home...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=5;spage=742;epage=748;aulast=Whitfield |
| _version_ | 1818606416522379264 |
|---|---|
| author | Marjorie Whitfield Xavier Pollet-Villard Rachel Levy Joël R Drevet Fabrice Saez |
| author_facet | Marjorie Whitfield Xavier Pollet-Villard Rachel Levy Joël R Drevet Fabrice Saez |
| author_sort | Marjorie Whitfield |
| collection | DOAJ |
| description | Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia) affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa. |
| first_indexed | 2024-12-16T14:10:31Z |
| format | Article |
| id | doaj.art-050455cc6b974af5a57e72157fab94b5 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-16T14:10:31Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-050455cc6b974af5a57e72157fab94b52022-12-21T22:28:47ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622015-01-0117574274810.4103/1008-682X.155536Posttesticular sperm maturation, infertility, and hypercholesterolemiaMarjorie WhitfieldXavier Pollet-VillardRachel LevyJoël R DrevetFabrice SaezCholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia) affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=5;spage=742;epage=748;aulast=Whitfieldcholesterol; dyslipidemia; epididymis; fertility; posttesticular maturation; spermatozoa |
| spellingShingle | Marjorie Whitfield Xavier Pollet-Villard Rachel Levy Joël R Drevet Fabrice Saez Posttesticular sperm maturation, infertility, and hypercholesterolemia Asian Journal of Andrology cholesterol; dyslipidemia; epididymis; fertility; posttesticular maturation; spermatozoa |
| title | Posttesticular sperm maturation, infertility, and hypercholesterolemia |
| title_full | Posttesticular sperm maturation, infertility, and hypercholesterolemia |
| title_fullStr | Posttesticular sperm maturation, infertility, and hypercholesterolemia |
| title_full_unstemmed | Posttesticular sperm maturation, infertility, and hypercholesterolemia |
| title_short | Posttesticular sperm maturation, infertility, and hypercholesterolemia |
| title_sort | posttesticular sperm maturation infertility and hypercholesterolemia |
| topic | cholesterol; dyslipidemia; epididymis; fertility; posttesticular maturation; spermatozoa |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=5;spage=742;epage=748;aulast=Whitfield |
| work_keys_str_mv | AT marjoriewhitfield posttesticularspermmaturationinfertilityandhypercholesterolemia AT xavierpolletvillard posttesticularspermmaturationinfertilityandhypercholesterolemia AT rachellevy posttesticularspermmaturationinfertilityandhypercholesterolemia AT joelrdrevet posttesticularspermmaturationinfertilityandhypercholesterolemia AT fabricesaez posttesticularspermmaturationinfertilityandhypercholesterolemia |