Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer
<p>Abstract</p> <p>Background</p> <p>MicroRNA let-7i has been proven to be down-regulated in many human malignancies and correlated with tumor progression and anticancer drug resistance. Our study aims to characterize the contribution of miRNA let-7i to the initiation a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | http://www.wjso.com/content/10/1/225 |
| _version_ | 1818118857128148992 |
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| author | Liu Kun Qian Tao Tang Liming Wang Jie Yang Haohua Ren Jun |
| author_facet | Liu Kun Qian Tao Tang Liming Wang Jie Yang Haohua Ren Jun |
| author_sort | Liu Kun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>MicroRNA let-7i has been proven to be down-regulated in many human malignancies and correlated with tumor progression and anticancer drug resistance. Our study aims to characterize the contribution of miRNA let-7i to the initiation and malignant progression of locally advanced gastric cancer (LAGC), and evaluate its possible value in neoadjuvant chemotherapeutic efficacy prediction.</p> <p>Methods</p> <p>Eighty-six previously untreated LAGC patients who underwent preoperative chemotherapy and radical resection were included in our study. Let-7i expression was examined for pairs of cancer tissues and corresponding normal adjacent tissues (NATs), using quantitative RT-PCR. The relationship of let-7i level to clinicopathological characteristics, pathologic tumor regression grades after chemotherapy, and overall survival (OS) was also investigated.</p> <p>Results</p> <p>Let-7i was significantly down-regulated in most tumor tissues (78/86: 91%) compared with paired NATs (<it>P</it> < 0.001), and low levels of let-7i were significantly correlated with local invasion, lymphatic metastasis, and poor pathologic tumor response. Multivariate Cox regression analysis revealed that low let-7i expression was an unfavorable prognostic factor of OS (hazard ratio (HR) = 2.316, <it>P</it> =0.024) independently of other clinicopathological factors, including tumor node metastasis (TNM) stage (HR = 3.226, <it>P</it> = 0.013), depth of infiltration (HR = 4.167, <it>P</it> < 0.001), and lymph node status (HR = 2.245, <it>P</it> = 0.037).</p> <p>Conclusions</p> <p>These findings indicate that let-7i may be a good candidate for use a therapeutic target and a potential tissue marker for the prediction of chemotherapeutic sensitivity and prognosis in LAGC patients.</p> |
| first_indexed | 2024-12-11T05:00:58Z |
| format | Article |
| id | doaj.art-050460c1912e43df855b62ace48e7824 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-11T05:00:58Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-050460c1912e43df855b62ace48e78242022-12-22T01:20:09ZengBMCWorld Journal of Surgical Oncology1477-78192012-10-0110122510.1186/1477-7819-10-225Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancerLiu KunQian TaoTang LimingWang JieYang HaohuaRen Jun<p>Abstract</p> <p>Background</p> <p>MicroRNA let-7i has been proven to be down-regulated in many human malignancies and correlated with tumor progression and anticancer drug resistance. Our study aims to characterize the contribution of miRNA let-7i to the initiation and malignant progression of locally advanced gastric cancer (LAGC), and evaluate its possible value in neoadjuvant chemotherapeutic efficacy prediction.</p> <p>Methods</p> <p>Eighty-six previously untreated LAGC patients who underwent preoperative chemotherapy and radical resection were included in our study. Let-7i expression was examined for pairs of cancer tissues and corresponding normal adjacent tissues (NATs), using quantitative RT-PCR. The relationship of let-7i level to clinicopathological characteristics, pathologic tumor regression grades after chemotherapy, and overall survival (OS) was also investigated.</p> <p>Results</p> <p>Let-7i was significantly down-regulated in most tumor tissues (78/86: 91%) compared with paired NATs (<it>P</it> < 0.001), and low levels of let-7i were significantly correlated with local invasion, lymphatic metastasis, and poor pathologic tumor response. Multivariate Cox regression analysis revealed that low let-7i expression was an unfavorable prognostic factor of OS (hazard ratio (HR) = 2.316, <it>P</it> =0.024) independently of other clinicopathological factors, including tumor node metastasis (TNM) stage (HR = 3.226, <it>P</it> = 0.013), depth of infiltration (HR = 4.167, <it>P</it> < 0.001), and lymph node status (HR = 2.245, <it>P</it> = 0.037).</p> <p>Conclusions</p> <p>These findings indicate that let-7i may be a good candidate for use a therapeutic target and a potential tissue marker for the prediction of chemotherapeutic sensitivity and prognosis in LAGC patients.</p>http://www.wjso.com/content/10/1/225Gastric cancerMicroRNA let-7iNeoadjuvant chemotherapyTumor response |
| spellingShingle | Liu Kun Qian Tao Tang Liming Wang Jie Yang Haohua Ren Jun Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer World Journal of Surgical Oncology Gastric cancer MicroRNA let-7i Neoadjuvant chemotherapy Tumor response |
| title | Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer |
| title_full | Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer |
| title_fullStr | Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer |
| title_full_unstemmed | Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer |
| title_short | Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer |
| title_sort | decreased expression of microrna let 7i and its association with chemotherapeutic response in human gastric cancer |
| topic | Gastric cancer MicroRNA let-7i Neoadjuvant chemotherapy Tumor response |
| url | http://www.wjso.com/content/10/1/225 |
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