Advances and Trends in Omics Technology Development
The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system. Yet, the ever-growing types of molecules and regulatory...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.911861/full |
| _version_ | 1818234178437644288 |
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| author | Xiaofeng Dai Li Shen |
| author_facet | Xiaofeng Dai Li Shen |
| author_sort | Xiaofeng Dai |
| collection | DOAJ |
| description | The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system. Yet, the ever-growing types of molecules and regulatory mechanisms being discovered have been persistently transforming our understandings on the cellular machinery. This renders cell omics seemingly, like the universe, expand with no limit and our goal toward the complete harness of the cellular system merely impossible. Therefore, it is imperative to review what has been done and is being done to predict what can be done toward the translation of omics information to disease control with minimal cell perturbation. With a focus on the “four big omics,” i.e., genomics, transcriptomics, proteomics, metabolomics, we delineate hierarchies of these omics together with their epiomics and interactomics, and review technologies developed for interrogation. We predict, among others, redoxomics as an emerging omics layer that views cell decision toward the physiological or pathological state as a fine-tuned redox balance. |
| first_indexed | 2024-12-12T11:33:57Z |
| format | Article |
| id | doaj.art-050510136ff440d1a4e74c56cf9b06ea |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T11:33:57Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-050510136ff440d1a4e74c56cf9b06ea2022-12-22T00:25:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-07-01910.3389/fmed.2022.911861911861Advances and Trends in Omics Technology DevelopmentXiaofeng DaiLi ShenThe human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system. Yet, the ever-growing types of molecules and regulatory mechanisms being discovered have been persistently transforming our understandings on the cellular machinery. This renders cell omics seemingly, like the universe, expand with no limit and our goal toward the complete harness of the cellular system merely impossible. Therefore, it is imperative to review what has been done and is being done to predict what can be done toward the translation of omics information to disease control with minimal cell perturbation. With a focus on the “four big omics,” i.e., genomics, transcriptomics, proteomics, metabolomics, we delineate hierarchies of these omics together with their epiomics and interactomics, and review technologies developed for interrogation. We predict, among others, redoxomics as an emerging omics layer that views cell decision toward the physiological or pathological state as a fine-tuned redox balance.https://www.frontiersin.org/articles/10.3389/fmed.2022.911861/fullomicsnext generation sequencingthird generation sequencingmass spectrometryredoxomics |
| spellingShingle | Xiaofeng Dai Li Shen Advances and Trends in Omics Technology Development Frontiers in Medicine omics next generation sequencing third generation sequencing mass spectrometry redoxomics |
| title | Advances and Trends in Omics Technology Development |
| title_full | Advances and Trends in Omics Technology Development |
| title_fullStr | Advances and Trends in Omics Technology Development |
| title_full_unstemmed | Advances and Trends in Omics Technology Development |
| title_short | Advances and Trends in Omics Technology Development |
| title_sort | advances and trends in omics technology development |
| topic | omics next generation sequencing third generation sequencing mass spectrometry redoxomics |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.911861/full |
| work_keys_str_mv | AT xiaofengdai advancesandtrendsinomicstechnologydevelopment AT lishen advancesandtrendsinomicstechnologydevelopment |