Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens
Abstract Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of s...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Clinical and Molecular Allergy |
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| Online Access: | https://doi.org/10.1186/s12948-022-00182-z |
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| author | Serhii Yuriev Victoria Rodinkova Vitalii Mokin Ilona Varchuk Olena Sharikadze Yuriy Marushko Bohdan Halushko Andrii Kurchenko |
| author_facet | Serhii Yuriev Victoria Rodinkova Vitalii Mokin Ilona Varchuk Olena Sharikadze Yuriy Marushko Bohdan Halushko Andrii Kurchenko |
| author_sort | Serhii Yuriev |
| collection | DOAJ |
| description | Abstract Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. Methods The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization. Results Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6. Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen. Conclusion The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life. |
| first_indexed | 2024-04-10T17:16:49Z |
| format | Article |
| id | doaj.art-0505aff6f2694cd0b4c217aad3dae10e |
| institution | Directory Open Access Journal |
| issn | 1476-7961 |
| language | English |
| last_indexed | 2024-04-10T17:16:49Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical and Molecular Allergy |
| spelling | doaj.art-0505aff6f2694cd0b4c217aad3dae10e2023-02-05T12:20:22ZengBMCClinical and Molecular Allergy1476-79612023-02-0121111110.1186/s12948-022-00182-zMolecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergensSerhii Yuriev0Victoria Rodinkova1Vitalii Mokin2Ilona Varchuk3Olena Sharikadze4Yuriy Marushko5Bohdan Halushko6Andrii Kurchenko7Medical Centre, DIVERODepartment of Pharmacy, National Pirogov Memorial Medical UniversityDepartment of System Analysis and Information Technologies, Vinnytsia National Technical UniversityDepartment of System Analysis and Information Technologies, Vinnytsia National Technical UniversityPaediatric Department, Shupyk National Healthcare UniversityDepartment of Pediatrics of Postgraduate Education, O.O. Bohomolets Medical UniversityDepartment of Pediatrics of Postgraduate Education, O.O. Bohomolets Medical UniversityDepartment of Clinical Immunology and Allergology, Bohomolets National Medical UniversityAbstract Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. Methods The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization. Results Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6. Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen. Conclusion The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.https://doi.org/10.1186/s12948-022-00182-zHouse dust mitesEnvironmental allergensComponent-resolved molecular diagnostics of allergyMolecular sensitization patternMultiplex allergy test |
| spellingShingle | Serhii Yuriev Victoria Rodinkova Vitalii Mokin Ilona Varchuk Olena Sharikadze Yuriy Marushko Bohdan Halushko Andrii Kurchenko Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens Clinical and Molecular Allergy House dust mites Environmental allergens Component-resolved molecular diagnostics of allergy Molecular sensitization pattern Multiplex allergy test |
| title | Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens |
| title_full | Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens |
| title_fullStr | Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens |
| title_full_unstemmed | Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens |
| title_short | Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens |
| title_sort | molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1 2 der p 23 der p 5 der p 7 and der p 21 allergens |
| topic | House dust mites Environmental allergens Component-resolved molecular diagnostics of allergy Molecular sensitization pattern Multiplex allergy test |
| url | https://doi.org/10.1186/s12948-022-00182-z |
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