Immunoglobulin Concentration in Tears of Contact Lens Wearers

Purpose: To evaluate changes in the concentration of tear immunoglobulins in contact lens wearers. Methods: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their...

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Main Authors: Rajendra P Maurya, Prashant Bhushan, Virendra P Singh, Mahendra K Singh, Prakash Kumar, Ravindra P.S. Bhatia, Usha Singh
Format: Article
Language:English
Published: Knowledge E 2014-01-01
Series:Journal of Ophthalmic & Vision Research
Subjects:
Online Access:http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=3;spage=320;epage=323;aulast=Maurya
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author Rajendra P Maurya
Prashant Bhushan
Virendra P Singh
Mahendra K Singh
Prakash Kumar
Ravindra P.S. Bhatia
Usha Singh
author_facet Rajendra P Maurya
Prashant Bhushan
Virendra P Singh
Mahendra K Singh
Prakash Kumar
Ravindra P.S. Bhatia
Usha Singh
author_sort Rajendra P Maurya
collection DOAJ
description Purpose: To evaluate changes in the concentration of tear immunoglobulins in contact lens wearers. Methods: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method. Results: Most of the cases used soft (56.6%) and semi-soft gas permeable (30.4%) contact lenses. Tear IgM was detected in only 17.4% and tear IgG in 43.6% of contact lens wearers, while in controls IgG was detected in 9.1% but none of the controls had IgM. There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl). Rise of tear IgA was more in symptomatic patients (15.38 ± 5.28 mg/dl) and in those wearing hard (19.73 ± 5.43 mg/dl) and semi-soft contact lenses (13.31 ± 5.43 mg/dl). A significant increase in tear IgA was noticed in subjects wearing lenses for >3 years (15.69 ± 5.39 mg/dl). About 43.4% of lens wearers were symptomatic and 80% of their lenses showed deposits and/or haziness. All cases with IgM in tear were symptomatic. Conclusion: The relation of immunoglobulin concentration with increasing duration of wear and material of contact lens shows that tear immunoglobulin rise accrues due to mechanical stimulation, hence contact lenses should not be used for a long period and lenses of hard nature should be discouraged. The maintenance, cleaning and deproteinization of the lenses are of high importance to avoid immunostimulation.
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spelling doaj.art-050689b648ff4cfb88c3ea79621ae2f22022-12-22T03:55:46ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-019332032310.4103/2008-322X.143368Immunoglobulin Concentration in Tears of Contact Lens WearersRajendra P MauryaPrashant BhushanVirendra P SinghMahendra K SinghPrakash KumarRavindra P.S. BhatiaUsha SinghPurpose: To evaluate changes in the concentration of tear immunoglobulins in contact lens wearers. Methods: A total of 45 cases including 23 contact lens wearers (43 eyes) and 22 age and sex matched healthy controls having no ocular pathology were studied for immunoglobulins (IgA, IgG, IgM) in their tears by single radial immunodiffusion method. Results: Most of the cases used soft (56.6%) and semi-soft gas permeable (30.4%) contact lenses. Tear IgM was detected in only 17.4% and tear IgG in 43.6% of contact lens wearers, while in controls IgG was detected in 9.1% but none of the controls had IgM. There was a significant rise in total tear IgA (13.17 ± 4.44 mg/dl) in contact lens wearer as compared to controls (8.93 ± 3.79 mg/dl). Rise of tear IgA was more in symptomatic patients (15.38 ± 5.28 mg/dl) and in those wearing hard (19.73 ± 5.43 mg/dl) and semi-soft contact lenses (13.31 ± 5.43 mg/dl). A significant increase in tear IgA was noticed in subjects wearing lenses for >3 years (15.69 ± 5.39 mg/dl). About 43.4% of lens wearers were symptomatic and 80% of their lenses showed deposits and/or haziness. All cases with IgM in tear were symptomatic. Conclusion: The relation of immunoglobulin concentration with increasing duration of wear and material of contact lens shows that tear immunoglobulin rise accrues due to mechanical stimulation, hence contact lenses should not be used for a long period and lenses of hard nature should be discouraged. The maintenance, cleaning and deproteinization of the lenses are of high importance to avoid immunostimulation.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=3;spage=320;epage=323;aulast=MauryaContact Lens; Radial Immunodiffusion Method; Tear Immunoglobulins
spellingShingle Rajendra P Maurya
Prashant Bhushan
Virendra P Singh
Mahendra K Singh
Prakash Kumar
Ravindra P.S. Bhatia
Usha Singh
Immunoglobulin Concentration in Tears of Contact Lens Wearers
Journal of Ophthalmic & Vision Research
Contact Lens; Radial Immunodiffusion Method; Tear Immunoglobulins
title Immunoglobulin Concentration in Tears of Contact Lens Wearers
title_full Immunoglobulin Concentration in Tears of Contact Lens Wearers
title_fullStr Immunoglobulin Concentration in Tears of Contact Lens Wearers
title_full_unstemmed Immunoglobulin Concentration in Tears of Contact Lens Wearers
title_short Immunoglobulin Concentration in Tears of Contact Lens Wearers
title_sort immunoglobulin concentration in tears of contact lens wearers
topic Contact Lens; Radial Immunodiffusion Method; Tear Immunoglobulins
url http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=3;spage=320;epage=323;aulast=Maurya
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