Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination
Rutin is a natural antioxidant flavonoid compound with anti-inflammatory, antioxidant, and antiviral effects that is used to prepare drugs with wide application in clinical treatment. Therefore, the quantitative detection of rutin has important practical significance. In this work, a novel electroch...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/11/3/171 |
| _version_ | 1797612810953293824 |
|---|---|
| author | Xin Meng Bao-Lin Xiao Xin-Yan Song Xin-Xin Ma Yang-Yang Li Lin-Lin Ma Yu-Jie Chen Yu-Ying Li Ke-Xin Xu Jian-She Wei Tao Hong Ali Akbar Moosavi-Movahedi Jun Hong |
| author_facet | Xin Meng Bao-Lin Xiao Xin-Yan Song Xin-Xin Ma Yang-Yang Li Lin-Lin Ma Yu-Jie Chen Yu-Ying Li Ke-Xin Xu Jian-She Wei Tao Hong Ali Akbar Moosavi-Movahedi Jun Hong |
| author_sort | Xin Meng |
| collection | DOAJ |
| description | Rutin is a natural antioxidant flavonoid compound with anti-inflammatory, antioxidant, and antiviral effects that is used to prepare drugs with wide application in clinical treatment. Therefore, the quantitative detection of rutin has important practical significance. In this work, a novel electrochemical sensor based on glassy carbon electrodes (GCEs) modified with sodium carboxymethylcellulose (CMC), multi-walled carbon nanotubes (MWCNTs), and 1-butyl-3-methylimid (ionic liquid, IL) was developed for the super-sensitive detection of the flavonoid rutin. The properties of these modified materials were analyzed by transmission electron microscope (TEM), cyclic voltammograms (CVs), and electrochemical-impedance spectroscopy (EIS). CMC was used to disperse MWCNTs to further enhance their hydrophilicity and biocompatibility. The modified MWCNTs improved the sensitivity of rutin detection. The square-wave voltammetry (SWV) technique showed that the linear range of rutin concentration determination was 0.01 μM to 1 µM and 1 µM to 10 µM. The minimum concentration detection of rutin was 0.83 nM and 6.6 nM, respectively. The proposed sensor presented good selectivity for rutin and successfully analyzed rutin content in the pharmaceutical rutin tablets. These results are consistent with those measured by ultra-high-performance liquid chromatography (UHPLC). Therefore, this sensor has latent application value in the analysis of rutin in food and drug tablets and nutraceutical samples. |
| first_indexed | 2024-03-11T06:46:17Z |
| format | Article |
| id | doaj.art-0506e69ec3194f8e9f785c6350d8ad63 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-11T06:46:17Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-0506e69ec3194f8e9f785c6350d8ad632023-11-17T10:16:16ZengMDPI AGChemosensors2227-90402023-03-0111317110.3390/chemosensors11030171Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin DeterminationXin Meng0Bao-Lin Xiao1Xin-Yan Song2Xin-Xin Ma3Yang-Yang Li4Lin-Lin Ma5Yu-Jie Chen6Yu-Ying Li7Ke-Xin Xu8Jian-She Wei9Tao Hong10Ali Akbar Moosavi-Movahedi11Jun Hong12School of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaSchool of Art, Henan University, Kaifeng 475000, ChinaInstitute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614418, IranSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaRutin is a natural antioxidant flavonoid compound with anti-inflammatory, antioxidant, and antiviral effects that is used to prepare drugs with wide application in clinical treatment. Therefore, the quantitative detection of rutin has important practical significance. In this work, a novel electrochemical sensor based on glassy carbon electrodes (GCEs) modified with sodium carboxymethylcellulose (CMC), multi-walled carbon nanotubes (MWCNTs), and 1-butyl-3-methylimid (ionic liquid, IL) was developed for the super-sensitive detection of the flavonoid rutin. The properties of these modified materials were analyzed by transmission electron microscope (TEM), cyclic voltammograms (CVs), and electrochemical-impedance spectroscopy (EIS). CMC was used to disperse MWCNTs to further enhance their hydrophilicity and biocompatibility. The modified MWCNTs improved the sensitivity of rutin detection. The square-wave voltammetry (SWV) technique showed that the linear range of rutin concentration determination was 0.01 μM to 1 µM and 1 µM to 10 µM. The minimum concentration detection of rutin was 0.83 nM and 6.6 nM, respectively. The proposed sensor presented good selectivity for rutin and successfully analyzed rutin content in the pharmaceutical rutin tablets. These results are consistent with those measured by ultra-high-performance liquid chromatography (UHPLC). Therefore, this sensor has latent application value in the analysis of rutin in food and drug tablets and nutraceutical samples.https://www.mdpi.com/2227-9040/11/3/171sensormulti-walled carbon nanotubesionic liquidsodium carboxymethylcelluloserutin |
| spellingShingle | Xin Meng Bao-Lin Xiao Xin-Yan Song Xin-Xin Ma Yang-Yang Li Lin-Lin Ma Yu-Jie Chen Yu-Ying Li Ke-Xin Xu Jian-She Wei Tao Hong Ali Akbar Moosavi-Movahedi Jun Hong Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination Chemosensors sensor multi-walled carbon nanotubes ionic liquid sodium carboxymethylcellulose rutin |
| title | Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination |
| title_full | Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination |
| title_fullStr | Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination |
| title_full_unstemmed | Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination |
| title_short | Highly Selective and Sensitive Sensor Based IL and CMC-MWCNTs Nanocomposite for Rutin Determination |
| title_sort | highly selective and sensitive sensor based il and cmc mwcnts nanocomposite for rutin determination |
| topic | sensor multi-walled carbon nanotubes ionic liquid sodium carboxymethylcellulose rutin |
| url | https://www.mdpi.com/2227-9040/11/3/171 |
| work_keys_str_mv | AT xinmeng highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT baolinxiao highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT xinyansong highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT xinxinma highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT yangyangli highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT linlinma highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT yujiechen highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT yuyingli highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT kexinxu highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT jianshewei highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT taohong highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT aliakbarmoosavimovahedi highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination AT junhong highlyselectiveandsensitivesensorbasedilandcmcmwcntsnanocompositeforrutindetermination |