Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction
Background: Higher levels of thyroid autoantibodies in follicular fluid (FF) of thyroid autoimmunity (TAI) positive women are strongly correlated with serum levels and may have effect on the post-implantation embryo development. Literature highlights that levothyroxine (LT4) treatment may attenuate...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582301027M.pdf |
| _version_ | 1828048837837586432 |
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| author | Medenica Sanja Garalejić Eliana Abazović Džihan Bukumirić Zoran Paschou Stavroula A. Arsić Biljana Vujošević Snežana Međo Biljana Žarković Miloš |
| author_facet | Medenica Sanja Garalejić Eliana Abazović Džihan Bukumirić Zoran Paschou Stavroula A. Arsić Biljana Vujošević Snežana Međo Biljana Žarković Miloš |
| author_sort | Medenica Sanja |
| collection | DOAJ |
| description | Background: Higher levels of thyroid autoantibodies in follicular fluid (FF) of thyroid autoimmunity (TAI) positive women are strongly correlated with serum levels and may have effect on the post-implantation embryo development. Literature highlights that levothyroxine (LT4) treatment may attenuate the risk of adverse pregnancy outcomes. The aim of the study was to estimate the pregnancy and newborn outcomes in women with FF thyroid autoantibodies undergoing assisted reproductive technology (A RT). Methods: The study population included 24 women with confirmed clinical pregnancy, 8 TAI positive and 16 TAI negative women. LT4 supplementation was applied in 20.8% patients, TAI positive. Results: Pregnancy outcomes were: twin pregnancy rate 4 1 .7 % , early miscarriage rate 8.3% , late miscarriage rate 4.2% , preterm birth rate 16.7% , term birth rate 70.8% , live birth rate 96.0% . There was significant difference in serum and in FF TgAbs (p< 0.001)betw een the groups according to TAI, while serum fT 3 was lower in the group with TAI (p = 0 .0 4 7 ). Serum P 4 was higher in LT4 treated group (p = 0 .0 0 5 ), with TAI, and newborns in this group had higher birth weight (p = 0.001) and height (p = 0 .0 0 8 ). Maternal complications occurred in 23.8% of patients. No congenital malformations in newborns were noted. Conclusions: Thyroid autoantibodies present in FF may have an effect on the post-implantation embryo development, but have no effect on further course of pregnancy. The special benefit of LT4 treatment for successful A R T outcome was demonstrated for newborn anthropometric parameters. |
| first_indexed | 2024-04-10T19:01:53Z |
| format | Article |
| id | doaj.art-0507e28dc1ba4064ba8730fb7e31592c |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-10T19:01:53Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-0507e28dc1ba4064ba8730fb7e31592c2023-01-31T08:14:07ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-01421273310.5937/jomb0-352431452-82582301027MPregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproductionMedenica Sanja0Garalejić Eliana1Abazović Džihan2Bukumirić Zoran3https://orcid.org/0000-0002-7609-4504Paschou Stavroula A.4Arsić Biljana5Vujošević Snežana6Međo Biljana7Žarković Miloš8University of Montenegro, School of Medicine, Clinical Center of Montenegro, Internal Medicine Clinic, Department of Endocrinology, Podgorica, MontenegroClinic for Gynecology and Obstetrics "Narodni front", In Vitro Fertilisation Department, Belgrade, SerbiaEmergency Medicine Center of Montenegro, Podgorica, Montenegro University of Belgrade, Institute for Medical Statistics and Informatics, Faculty of Medicine, Belgrade, SerbiaNational and Kapodistrian University of Athens, School of Medicine, Alexandra Hospital, Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Athens, GreeceClinic for Gynecology and Obstetrics "Narodni front", In Vitro Fertilisation Department, Belgrade, SerbiaUniversity of Montenegro, School of Medicine, Clinical Center of Montenegro, Internal Medicine Clinic, Department of Endocrinology, Podgorica, MontenegroUniversity of Belgrade, School of Medicine, Belgrade, SerbiaUniversity of Belgrade, School of Medicine, Belgrade, SerbiaBackground: Higher levels of thyroid autoantibodies in follicular fluid (FF) of thyroid autoimmunity (TAI) positive women are strongly correlated with serum levels and may have effect on the post-implantation embryo development. Literature highlights that levothyroxine (LT4) treatment may attenuate the risk of adverse pregnancy outcomes. The aim of the study was to estimate the pregnancy and newborn outcomes in women with FF thyroid autoantibodies undergoing assisted reproductive technology (A RT). Methods: The study population included 24 women with confirmed clinical pregnancy, 8 TAI positive and 16 TAI negative women. LT4 supplementation was applied in 20.8% patients, TAI positive. Results: Pregnancy outcomes were: twin pregnancy rate 4 1 .7 % , early miscarriage rate 8.3% , late miscarriage rate 4.2% , preterm birth rate 16.7% , term birth rate 70.8% , live birth rate 96.0% . There was significant difference in serum and in FF TgAbs (p< 0.001)betw een the groups according to TAI, while serum fT 3 was lower in the group with TAI (p = 0 .0 4 7 ). Serum P 4 was higher in LT4 treated group (p = 0 .0 0 5 ), with TAI, and newborns in this group had higher birth weight (p = 0.001) and height (p = 0 .0 0 8 ). Maternal complications occurred in 23.8% of patients. No congenital malformations in newborns were noted. Conclusions: Thyroid autoantibodies present in FF may have an effect on the post-implantation embryo development, but have no effect on further course of pregnancy. The special benefit of LT4 treatment for successful A R T outcome was demonstrated for newborn anthropometric parameters.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582301027M.pdfassisted reproductive technologyfollicular fluidpregnancythyroid autoimmunity |
| spellingShingle | Medenica Sanja Garalejić Eliana Abazović Džihan Bukumirić Zoran Paschou Stavroula A. Arsić Biljana Vujošević Snežana Međo Biljana Žarković Miloš Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction Journal of Medical Biochemistry assisted reproductive technology follicular fluid pregnancy thyroid autoimmunity |
| title | Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction |
| title_full | Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction |
| title_fullStr | Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction |
| title_full_unstemmed | Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction |
| title_short | Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction |
| title_sort | pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction |
| topic | assisted reproductive technology follicular fluid pregnancy thyroid autoimmunity |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582301027M.pdf |
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