Colonic malakoplakia in a pediatric renal transplant recipient case report
Malakoplakia is a rare, chronic granulomatous disease that mainly affects the genitourinary system of immunocompromised adults. It is caused by a bactericidal deficit in macrophages and, therefore, the treatment includes antimicrobials that reach high concentrations in macrophages. To our knowledge,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-03-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X241239866 |
| _version_ | 1797257655283089408 |
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| author | Kristen G Valencia Deray Richard Kellermayer Alexis C Gomez Kalyani R Patel Peace Imani Seiji Kitagawa Claire E Bocchini Alvaro Orjuela |
| author_facet | Kristen G Valencia Deray Richard Kellermayer Alexis C Gomez Kalyani R Patel Peace Imani Seiji Kitagawa Claire E Bocchini Alvaro Orjuela |
| author_sort | Kristen G Valencia Deray |
| collection | DOAJ |
| description | Malakoplakia is a rare, chronic granulomatous disease that mainly affects the genitourinary system of immunocompromised adults. It is caused by a bactericidal deficit in macrophages and, therefore, the treatment includes antimicrobials that reach high concentrations in macrophages. To our knowledge, we present the first case of malakoplakia in a pediatric solid organ transplant recipient. Our patient is a 15-year-old male renal transplant recipient who presented with recurrent diarrhea. Blood, urine, and gastrointestinal pathogen panel testing were positive for enteroaggregative Escherichia coli. A colonoscopy revealed diffuse malakoplakia. He had a complete resolution of symptoms with trimethoprim-sulfamethoxazole therapy. Unfortunately, his malakoplakia recurred after 9 months prompting the transition of therapy to oral gentamicin with subsequent remission. Malakoplakia should be considered in the differential of solid organ transplant recipients with recurrent gastrointestinal infections. |
| first_indexed | 2024-04-24T22:41:05Z |
| format | Article |
| id | doaj.art-050a7c8b8a064df6951f011095eea945 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-04-24T22:41:05Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-050a7c8b8a064df6951f011095eea9452024-03-19T01:03:19ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2024-03-011210.1177/2050313X241239866Colonic malakoplakia in a pediatric renal transplant recipient case reportKristen G Valencia Deray0Richard Kellermayer1Alexis C Gomez2Kalyani R Patel3Peace Imani4Seiji Kitagawa5Claire E Bocchini6Alvaro Orjuela7Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USADivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USADivision of Pediatric Nephrology, Department of Pediatrics, Boston Children’s Hospital, Boston, MA, USADepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USADivision of Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USADivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USADivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USADivision of Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USAMalakoplakia is a rare, chronic granulomatous disease that mainly affects the genitourinary system of immunocompromised adults. It is caused by a bactericidal deficit in macrophages and, therefore, the treatment includes antimicrobials that reach high concentrations in macrophages. To our knowledge, we present the first case of malakoplakia in a pediatric solid organ transplant recipient. Our patient is a 15-year-old male renal transplant recipient who presented with recurrent diarrhea. Blood, urine, and gastrointestinal pathogen panel testing were positive for enteroaggregative Escherichia coli. A colonoscopy revealed diffuse malakoplakia. He had a complete resolution of symptoms with trimethoprim-sulfamethoxazole therapy. Unfortunately, his malakoplakia recurred after 9 months prompting the transition of therapy to oral gentamicin with subsequent remission. Malakoplakia should be considered in the differential of solid organ transplant recipients with recurrent gastrointestinal infections.https://doi.org/10.1177/2050313X241239866 |
| spellingShingle | Kristen G Valencia Deray Richard Kellermayer Alexis C Gomez Kalyani R Patel Peace Imani Seiji Kitagawa Claire E Bocchini Alvaro Orjuela Colonic malakoplakia in a pediatric renal transplant recipient case report SAGE Open Medical Case Reports |
| title | Colonic malakoplakia in a pediatric renal transplant recipient case report |
| title_full | Colonic malakoplakia in a pediatric renal transplant recipient case report |
| title_fullStr | Colonic malakoplakia in a pediatric renal transplant recipient case report |
| title_full_unstemmed | Colonic malakoplakia in a pediatric renal transplant recipient case report |
| title_short | Colonic malakoplakia in a pediatric renal transplant recipient case report |
| title_sort | colonic malakoplakia in a pediatric renal transplant recipient case report |
| url | https://doi.org/10.1177/2050313X241239866 |
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