Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study
Aim:We emphasize the importance of serum native thiol (SH), lipid peroxidation (LOOH), and ceruloplasmin (CP) levels in the management of patients with a migraine attack and clarify the possible relationships among these parameters in the emergency department (ED).Methods:The study was designed as a...
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Galenos Yayinevi
2021-09-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/plasma-native-thiol-and-lipid-hydroperoxide-levels/48300
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| author | Mehmet Tahir Gokdemir Ozgur Sogut Cihan Gul Elif Demir Huseyin Ergenc |
| author_facet | Mehmet Tahir Gokdemir Ozgur Sogut Cihan Gul Elif Demir Huseyin Ergenc |
| author_sort | Mehmet Tahir Gokdemir |
| collection | DOAJ |
| description | Aim:We emphasize the importance of serum native thiol (SH), lipid peroxidation (LOOH), and ceruloplasmin (CP) levels in the management of patients with a migraine attack and clarify the possible relationships among these parameters in the emergency department (ED).Methods:The study was designed as a case-control study which is a type of observational study by including the patients who applied to the University of Health Sciences Turkey, University Diyarbakır Gazi Yasargil Training and Research Hospital between December 2018 and July 2019. A total of 88 participants (study group, n=46 and healthy control group, n=42) consecutively admitted to the ED. with similar demographic characteristics were included in the study. SH, LOOH, and CP levels in both groups were recorded and studied.Results:The serum SH level was significantly lower in the patient than in the control group (p=0.002). However, the LOOH and CP levels were significantly higher in the patient group than in the control group (p<0.001). A significant correlation was observed between LOOH and CP (r=0.332, p=0.002). The receiver operating characteristic analysis indicated that a serum LOOH level of 11.9 μmol/L predicted an acute migraine attack with 89% sensitivity and 71% specificity.Conclusions:Our results suggest that the oxidative status is activated in patients with a non-aura migraine attack, and this may lead to other oxidative and inflammatory processes, with an increase in the serum LOOH level and a decrease in the native thiol level. |
| first_indexed | 2024-04-10T13:45:12Z |
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| id | doaj.art-050dc2fd68f14037aa48a8261ad94417 |
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| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T13:45:12Z |
| publishDate | 2021-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-050dc2fd68f14037aa48a8261ad944172023-02-15T16:10:59ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882021-09-0159429530110.4274/haseki.galenos.2021.707413049054Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control StudyMehmet Tahir Gokdemir0Ozgur Sogut1Cihan Gul2Elif Demir3Huseyin Ergenc4 Batman University Faculty of Health, Department of Emergency Medicine, Batman, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Emergency Service, Istanbul, Turkey Batman University Health Care and Vocational School, Department of Nursing Education, Batman, Turkey Harran University Faculty of Medicine, Department of Biochemistry Department, Sanliurfa, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Emergency Service, Istanbul, Turkey Aim:We emphasize the importance of serum native thiol (SH), lipid peroxidation (LOOH), and ceruloplasmin (CP) levels in the management of patients with a migraine attack and clarify the possible relationships among these parameters in the emergency department (ED).Methods:The study was designed as a case-control study which is a type of observational study by including the patients who applied to the University of Health Sciences Turkey, University Diyarbakır Gazi Yasargil Training and Research Hospital between December 2018 and July 2019. A total of 88 participants (study group, n=46 and healthy control group, n=42) consecutively admitted to the ED. with similar demographic characteristics were included in the study. SH, LOOH, and CP levels in both groups were recorded and studied.Results:The serum SH level was significantly lower in the patient than in the control group (p=0.002). However, the LOOH and CP levels were significantly higher in the patient group than in the control group (p<0.001). A significant correlation was observed between LOOH and CP (r=0.332, p=0.002). The receiver operating characteristic analysis indicated that a serum LOOH level of 11.9 μmol/L predicted an acute migraine attack with 89% sensitivity and 71% specificity.Conclusions:Our results suggest that the oxidative status is activated in patients with a non-aura migraine attack, and this may lead to other oxidative and inflammatory processes, with an increase in the serum LOOH level and a decrease in the native thiol level. http://www.hasekidergisi.com/archives/archive-detail/article-preview/plasma-native-thiol-and-lipid-hydroperoxide-levels/48300 non-aura migrainenative thiollipid peroxidationemergency department |
| spellingShingle | Mehmet Tahir Gokdemir Ozgur Sogut Cihan Gul Elif Demir Huseyin Ergenc Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study Haseki Tıp Bülteni non-aura migraine native thiol lipid peroxidation emergency department |
| title | Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study |
| title_full | Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study |
| title_fullStr | Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study |
| title_full_unstemmed | Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study |
| title_short | Plasma Native Thiol and Lipid Hydroperoxide Levels in the Patients with A Non-Aura Migraine Attack Admitted to the Emergency Department: A Case- Control Study |
| title_sort | plasma native thiol and lipid hydroperoxide levels in the patients with a non aura migraine attack admitted to the emergency department a case control study |
| topic | non-aura migraine native thiol lipid peroxidation emergency department |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/plasma-native-thiol-and-lipid-hydroperoxide-levels/48300
|
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