Expanding the reach of commercial cell therapies requires changes at medical centers
Abstract The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. However, cell therapies are now increasin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-04966-6 |
| _version_ | 1797273436912877568 |
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| author | David F. Stroncek Nan Zhang Jiaqiang Ren Rob Somerville Anh Dinh |
| author_facet | David F. Stroncek Nan Zhang Jiaqiang Ren Rob Somerville Anh Dinh |
| author_sort | David F. Stroncek |
| collection | DOAJ |
| description | Abstract The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. However, cell therapies are now increasingly being produced in centralized manufacturing facilities and shipped to medical centers for administration. Typically, these cell therapies are produced from a patient’s own cells, which are the critical starting material. For these therapies to achieve their full potential, more medical centers must develop the infrastructure to collect, label, cryopreserve, test, and ship these cells to the centralized laboratories where these cell therapies are manufactured. Medical centers must also develop systems to receive, store, and infuse the finished cell therapy products. Since most cell therapies are cryopreserved for shipment and storage, medical centers using these therapies will require access to liquid nitrogen product storage tanks and develop procedures to thaw cell therapies. These services could be provided by the hospital pharmacy or transfusion service, but the latter is likely most appropriate. Another barrier to implementing these services is the variability among providers of these cell therapies in the processes related to handling cell therapies. The provision of these services by medical centers would be facilitated by establishing a national coordinating center and a network of apheresis centers to collect and cryopreserve the cells needed to begin the manufacturing process and cell therapy laboratories to store and issue the cells. In addition to organizing cell collections, the coordinating center could establish uniform practices for collecting, labeling, shipping, receiving, thawing, and infusing the cell therapy. |
| first_indexed | 2024-03-07T14:43:17Z |
| format | Article |
| id | doaj.art-0510a849cc8a462f9c68ad81b9daac86 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-07T14:43:17Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-0510a849cc8a462f9c68ad81b9daac862024-03-05T20:07:07ZengBMCJournal of Translational Medicine1479-58762024-02-012211510.1186/s12967-024-04966-6Expanding the reach of commercial cell therapies requires changes at medical centersDavid F. Stroncek0Nan Zhang1Jiaqiang Ren2Rob Somerville3Anh Dinh4The Center for Cellular Engineering, Department of Transfusion Medicine, NIH Clinical CenterThe Center for Cellular Engineering, Department of Transfusion Medicine, NIH Clinical CenterThe Center for Cellular Engineering, Department of Transfusion Medicine, NIH Clinical CenterThe Center for Cellular Engineering, Department of Transfusion Medicine, NIH Clinical CenterThe Center for Cellular Engineering, Department of Transfusion Medicine, NIH Clinical CenterAbstract The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. However, cell therapies are now increasingly being produced in centralized manufacturing facilities and shipped to medical centers for administration. Typically, these cell therapies are produced from a patient’s own cells, which are the critical starting material. For these therapies to achieve their full potential, more medical centers must develop the infrastructure to collect, label, cryopreserve, test, and ship these cells to the centralized laboratories where these cell therapies are manufactured. Medical centers must also develop systems to receive, store, and infuse the finished cell therapy products. Since most cell therapies are cryopreserved for shipment and storage, medical centers using these therapies will require access to liquid nitrogen product storage tanks and develop procedures to thaw cell therapies. These services could be provided by the hospital pharmacy or transfusion service, but the latter is likely most appropriate. Another barrier to implementing these services is the variability among providers of these cell therapies in the processes related to handling cell therapies. The provision of these services by medical centers would be facilitated by establishing a national coordinating center and a network of apheresis centers to collect and cryopreserve the cells needed to begin the manufacturing process and cell therapy laboratories to store and issue the cells. In addition to organizing cell collections, the coordinating center could establish uniform practices for collecting, labeling, shipping, receiving, thawing, and infusing the cell therapy.https://doi.org/10.1186/s12967-024-04966-6Cell therapiesCancer immunotherapiesApheresis |
| spellingShingle | David F. Stroncek Nan Zhang Jiaqiang Ren Rob Somerville Anh Dinh Expanding the reach of commercial cell therapies requires changes at medical centers Journal of Translational Medicine Cell therapies Cancer immunotherapies Apheresis |
| title | Expanding the reach of commercial cell therapies requires changes at medical centers |
| title_full | Expanding the reach of commercial cell therapies requires changes at medical centers |
| title_fullStr | Expanding the reach of commercial cell therapies requires changes at medical centers |
| title_full_unstemmed | Expanding the reach of commercial cell therapies requires changes at medical centers |
| title_short | Expanding the reach of commercial cell therapies requires changes at medical centers |
| title_sort | expanding the reach of commercial cell therapies requires changes at medical centers |
| topic | Cell therapies Cancer immunotherapies Apheresis |
| url | https://doi.org/10.1186/s12967-024-04966-6 |
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