“Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit
Background: Neonatal sepsis is one of the most common causes of neonatal mortality and morbidity, particularly in the developing countries. Its causative bacteria and their respective sensitivity patterns are different in each hospital and region. The objective of this study was to determine the...
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JCDR Research and Publications Private Limited
2013-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/3594/26-%206796_E(%20_%20)_F(H)_PF1(VH)_PFA(H)_OLF_PF2(PP).pdf |
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| author | Chandra Madhur Sharma Ravi Prakash Agrawal Hariom Sharan Bijay Kumar Deepti Sharma Santokh Singh Bhatia |
| author_facet | Chandra Madhur Sharma Ravi Prakash Agrawal Hariom Sharan Bijay Kumar Deepti Sharma Santokh Singh Bhatia |
| author_sort | Chandra Madhur Sharma |
| collection | DOAJ |
| description | Background: Neonatal sepsis is one of the most common
causes of neonatal mortality and morbidity, particularly in the
developing countries. Its causative bacteria and their respective
sensitivity patterns are different in each hospital and region.
The objective of this study was to determine the causative
bacteria and pattern of susceptibility to antibiotics in NICU of a
tertiary care centre, which in turn may help in implementation of
empirical therapy.
Material and Methods: This prospective study was carried
out at a medical college during the period from 1st April 2011
to 31st March 2013. A total of 364 cases of suspected sepsis
were admitted in our NICU during the mentioned period. Out of
which, 137 cases were positive for culture. All the neonates of
suspected sepsis were screened by using a panel consisting of
CRP, ANC, I/T ratio, micro ESR and culture and sensitivity.
Results: A total of 137 cultures were found to be positive
out of 364 cases. The most common organism isolated was
Staphylococcus aureus (37.22%) followed by Klebsiella
pneumoniae (27.01%) and Escherichia coli (19.70%). Other
organisms were much less in number, which included pathogenic
Streptococci, Coagulase negative Staphylococci (CoNS),
Pseudomonas, Acinetobacter and Enterobacter species. The
gram positive organisms except Streptococci displayed a high
degree of resistance to most penicillins and ciprofloxacin but
were sensitive to vancomycin, amikacin and cefepime. There
was a high incidence of resistance noted with ampicillin,
gentamicin and ciprofloxacin amongst most gram negative
organisms’ where-in cefepime, amikacin and meropenem were
effective in most cases.
Conclusion: There is an increasing trend of antibiotic resistance
to the commonly used first line drugs. Continuous surveillance
for antibiotic susceptibility is needed to ensure proper empirical
therapy. |
| first_indexed | 2024-12-13T12:41:00Z |
| format | Article |
| id | doaj.art-0510e7c11667484a9105b8a679d9ae8f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T12:41:00Z |
| publishDate | 2013-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0510e7c11667484a9105b8a679d9ae8f2022-12-21T23:45:38ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-11-017112511251310.7860/JCDR/2013/6796.3594“Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care UnitChandra Madhur Sharma0Ravi Prakash Agrawal1Hariom Sharan2Bijay Kumar3Deepti Sharma4Santokh Singh Bhatia5Assistant Professor, Department of Paediatrics, Rama Medical College, Hospital and Research Centre, Kanpur, India.Assistant Professor, Department of Paediatrics, Rama Medical College, Hospital and Research Centre, Kanpur, India.Assistant Professor, Department of Microbiology, Rama Medical College, Hospital and Research Centre, Kanpur, India.Associate Professor, Department of Pharmacology, Rama Medical College, Hospital and Research Centre, Kanpur, India.Junior Resident, Department of Obstetrics & Gynaecology, G.S.V.M. Medical College, Kanpur, India. Associate Professor, Department of Paediatrics, Rama Medical College, Hospital and Research Centre, Kanpur, India.Background: Neonatal sepsis is one of the most common causes of neonatal mortality and morbidity, particularly in the developing countries. Its causative bacteria and their respective sensitivity patterns are different in each hospital and region. The objective of this study was to determine the causative bacteria and pattern of susceptibility to antibiotics in NICU of a tertiary care centre, which in turn may help in implementation of empirical therapy. Material and Methods: This prospective study was carried out at a medical college during the period from 1st April 2011 to 31st March 2013. A total of 364 cases of suspected sepsis were admitted in our NICU during the mentioned period. Out of which, 137 cases were positive for culture. All the neonates of suspected sepsis were screened by using a panel consisting of CRP, ANC, I/T ratio, micro ESR and culture and sensitivity. Results: A total of 137 cultures were found to be positive out of 364 cases. The most common organism isolated was Staphylococcus aureus (37.22%) followed by Klebsiella pneumoniae (27.01%) and Escherichia coli (19.70%). Other organisms were much less in number, which included pathogenic Streptococci, Coagulase negative Staphylococci (CoNS), Pseudomonas, Acinetobacter and Enterobacter species. The gram positive organisms except Streptococci displayed a high degree of resistance to most penicillins and ciprofloxacin but were sensitive to vancomycin, amikacin and cefepime. There was a high incidence of resistance noted with ampicillin, gentamicin and ciprofloxacin amongst most gram negative organisms’ where-in cefepime, amikacin and meropenem were effective in most cases. Conclusion: There is an increasing trend of antibiotic resistance to the commonly used first line drugs. Continuous surveillance for antibiotic susceptibility is needed to ensure proper empirical therapy.https://jcdr.net/articles/PDF/3594/26-%206796_E(%20_%20)_F(H)_PF1(VH)_PFA(H)_OLF_PF2(PP).pdfneonatesempirical therapyearly onset sepsislate onset sepsisantimicrobial sensitivity |
| spellingShingle | Chandra Madhur Sharma Ravi Prakash Agrawal Hariom Sharan Bijay Kumar Deepti Sharma Santokh Singh Bhatia “Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit Journal of Clinical and Diagnostic Research neonates empirical therapy early onset sepsis late onset sepsis antimicrobial sensitivity |
| title | “Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit |
| title_full | “Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit |
| title_fullStr | “Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit |
| title_full_unstemmed | “Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit |
| title_short | “Neonatal Sepsis”: Bacteria & their Susceptibility Pattern towards Antibiotics in Neonatal Intensive Care Unit |
| title_sort | neonatal sepsis bacteria their susceptibility pattern towards antibiotics in neonatal intensive care unit |
| topic | neonates empirical therapy early onset sepsis late onset sepsis antimicrobial sensitivity |
| url | https://jcdr.net/articles/PDF/3594/26-%206796_E(%20_%20)_F(H)_PF1(VH)_PFA(H)_OLF_PF2(PP).pdf |
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