Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting
Aim.To give comparative characteristics of the prevalence of polymorphic alleles in the genes of the hemostatic system PAI-1 (-675 5G/4G) and FGB (-455 G/A) in patients with sudden cardiac death and those with acute coronary syndrome undergoing coronary artery stenting.Material and methods.Genetic t...
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| Format: | Article |
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Eco-vector
2020-10-01
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| Series: | Судебная Медицина |
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| Online Access: | https://for-medex.ru/jour/article/viewFile/319/303 |
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| author | Dmitriy P. Berezovskiy Irina A. Kolomoets Stanislav S. Bachurin Vladimir N. Egorov Tatiana V. Tayutina |
| author_facet | Dmitriy P. Berezovskiy Irina A. Kolomoets Stanislav S. Bachurin Vladimir N. Egorov Tatiana V. Tayutina |
| author_sort | Dmitriy P. Berezovskiy |
| collection | DOAJ |
| description | Aim.To give comparative characteristics of the prevalence of polymorphic alleles in the genes of the hemostatic system PAI-1 (-675 5G/4G) and FGB (-455 G/A) in patients with sudden cardiac death and those with acute coronary syndrome undergoing coronary artery stenting.Material and methods.Genetic typing of biological material (BM) was performed for the prevalence of polymorphic alleles in two genes of the hemostasis system. BM was selected from people with a diagnosis of coronary artery disease, divided into three comparison groups: I-suddenly deceased citizens with a diagnosis of coronary artery disease, II-patients with ACS who underwent urgent coronary artery stenting, and III-patients with a chronic form of coronary artery disease in whom endovascular surgery was performed as planned.Results.The calculated criterion 2of the prevalence of polymorphisms in the FGB (-455 G/A) and PAI-1 (-675 5G/4G) genes turned out to be more than the critical (tabular) value, which indicates an existing relationship between the presence of IHD and the carriage of one of the polymorphic alleles. Based on the same data, the 2criterion was calculated without taking into account data for a group of healthy citizens. For carriers of the polymorphic allele of the FGB gene (-455 G/A), no statistically significant differences were found. For carriers of the PAI-1 gene polymorphic allele (-675 5G/4G), statistically significant differences were found.Conclusions.ACS with a favorable outcome (subject to emergency surgical intervention) occurs at an earlier age than in patients diagnosed with coronary artery disease who die suddenly. The presence of a mutant allele in the PAI-1 gene (-675 5G/4G) requires further studies in order to expertly assess the death rate in patients after surgery with coronary stenting. |
| first_indexed | 2024-03-12T10:44:13Z |
| format | Article |
| id | doaj.art-0512b5ee261c449bbd20a4155dd630a6 |
| institution | Directory Open Access Journal |
| issn | 2411-8729 2409-4161 |
| language | English |
| last_indexed | 2024-03-12T10:44:13Z |
| publishDate | 2020-10-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Судебная Медицина |
| spelling | doaj.art-0512b5ee261c449bbd20a4155dd630a62023-09-02T07:42:21ZengEco-vectorСудебная Медицина2411-87292409-41612020-10-0163202610.19048/fm319290Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stentingDmitriy P. Berezovskiy0https://orcid.org/0000-0002-8502-1331Irina A. Kolomoets1https://orcid.org/0000-0001-7736-1400Stanislav S. Bachurin2https://orcid.org/0000-0002-4349-5897Vladimir N. Egorov3https://orcid.org/0000-0002-0661-9985Tatiana V. Tayutina4https://orcid.org/0000-0002-5421-4202I.M. Sechenov First Moscow State University (Sechenov University)Rostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityAim.To give comparative characteristics of the prevalence of polymorphic alleles in the genes of the hemostatic system PAI-1 (-675 5G/4G) and FGB (-455 G/A) in patients with sudden cardiac death and those with acute coronary syndrome undergoing coronary artery stenting.Material and methods.Genetic typing of biological material (BM) was performed for the prevalence of polymorphic alleles in two genes of the hemostasis system. BM was selected from people with a diagnosis of coronary artery disease, divided into three comparison groups: I-suddenly deceased citizens with a diagnosis of coronary artery disease, II-patients with ACS who underwent urgent coronary artery stenting, and III-patients with a chronic form of coronary artery disease in whom endovascular surgery was performed as planned.Results.The calculated criterion 2of the prevalence of polymorphisms in the FGB (-455 G/A) and PAI-1 (-675 5G/4G) genes turned out to be more than the critical (tabular) value, which indicates an existing relationship between the presence of IHD and the carriage of one of the polymorphic alleles. Based on the same data, the 2criterion was calculated without taking into account data for a group of healthy citizens. For carriers of the polymorphic allele of the FGB gene (-455 G/A), no statistically significant differences were found. For carriers of the PAI-1 gene polymorphic allele (-675 5G/4G), statistically significant differences were found.Conclusions.ACS with a favorable outcome (subject to emergency surgical intervention) occurs at an earlier age than in patients diagnosed with coronary artery disease who die suddenly. The presence of a mutant allele in the PAI-1 gene (-675 5G/4G) requires further studies in order to expertly assess the death rate in patients after surgery with coronary stenting.https://for-medex.ru/jour/article/viewFile/319/303coronary heart diseasesudden cardiac deathpolymorphismfibrinogenplasminogen activator inhibitor |
| spellingShingle | Dmitriy P. Berezovskiy Irina A. Kolomoets Stanislav S. Bachurin Vladimir N. Egorov Tatiana V. Tayutina Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting Судебная Медицина coronary heart disease sudden cardiac death polymorphism fibrinogen plasminogen activator inhibitor |
| title | Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting |
| title_full | Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting |
| title_fullStr | Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting |
| title_full_unstemmed | Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting |
| title_short | Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting |
| title_sort | comparative characteristics of polymorphic allele propagation in the hemostasis system genes pai 1 675 5g 4g and fgb 455 g a in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting |
| topic | coronary heart disease sudden cardiac death polymorphism fibrinogen plasminogen activator inhibitor |
| url | https://for-medex.ru/jour/article/viewFile/319/303 |
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