TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity

TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity

Abstract Background TMEM52B is a novel gene broadly expressed in a variety of normal human tissues. However, the biological function of TMEM52B expression in cancer is largely unknown. Methods The effects of TMEM52B on tumor growth and metastasis were investigated in vitro and in vivo, and the under...

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Bibliographic Details
Main Authors: Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Younghoon Lee, Semi Kim
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TMEM52B
Cell survival
Invasion
EGFR
E-cadherin
Prognostic marker
Online Access:https://doi.org/10.1186/s13046-021-01828-7

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