Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease
Objectives: Patients with familial hypercholesterolemia (FH) are at a very high risk of coronary artery diseases. The aim of the present study was to clarify the characteristics of coronary plaque in patients with FH. Design: and Methods: A total of 569 patients who underwent optical coherence tomog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Practical Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352551721000020 |
| _version_ | 1818440474311000064 |
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| author | Masahiro Katamine Yoshiyasu Minami Takuya Hashimoto Junya Ako |
| author_facet | Masahiro Katamine Yoshiyasu Minami Takuya Hashimoto Junya Ako |
| author_sort | Masahiro Katamine |
| collection | DOAJ |
| description | Objectives: Patients with familial hypercholesterolemia (FH) are at a very high risk of coronary artery diseases. The aim of the present study was to clarify the characteristics of coronary plaque in patients with FH. Design: and Methods: A total of 569 patients who underwent optical coherence tomography (OCT) imaging of culprit plaque were included. The characteristics of culprit plaque were compared between patients with and without FH. Results: A total of 38 patients (6.7%) were clinically diagnosed with FH. The location of the culprit plaque was significantly different (p < 0.001) with a trend toward higher frequency of left main lesion in the FH group than in the group with no FH (7.9 vs. 0%). Culprit plaque was significantly shorter in patients with FH than those without FH (28.1 vs. 33.2 mm, p = 0.016). A trend toward higher prevalence of plaque with macrophage accumulation in patients with FH than those without FH (50.0 vs. 34.7%, p = 0.056) was observed, although the prevalence of other vulnerable characteristics including thin-cap fibroatheroma (TCFA) was comparable between patients with and without FH. Among patients with FH, significant increases in the prevalence of lipid-rich plaque (p = 0.028) and TCFA (p = 0.003) were observed according to the increase in low-density lipoprotein cholesterol (LDL-C) levels. Conclusions: Patients with FH had shorter culprit plaque without significant difference in the prevalence of vulnerable plaque components compared with patients without FH. A higher LDL-C level was associated with higher prevalence of vulnerable plaque in patients with FH. |
| first_indexed | 2024-12-14T18:12:56Z |
| format | Article |
| id | doaj.art-05134be928aa4ff4b2a417ffc2c99f5e |
| institution | Directory Open Access Journal |
| issn | 2352-5517 |
| language | English |
| last_indexed | 2024-12-14T18:12:56Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Practical Laboratory Medicine |
| spelling | doaj.art-05134be928aa4ff4b2a417ffc2c99f5e2022-12-21T22:52:15ZengElsevierPractical Laboratory Medicine2352-55172021-03-0124e00202Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery diseaseMasahiro Katamine0Yoshiyasu Minami1Takuya Hashimoto2Junya Ako3Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, JapanCorresponding author. Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, JapanDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, JapanObjectives: Patients with familial hypercholesterolemia (FH) are at a very high risk of coronary artery diseases. The aim of the present study was to clarify the characteristics of coronary plaque in patients with FH. Design: and Methods: A total of 569 patients who underwent optical coherence tomography (OCT) imaging of culprit plaque were included. The characteristics of culprit plaque were compared between patients with and without FH. Results: A total of 38 patients (6.7%) were clinically diagnosed with FH. The location of the culprit plaque was significantly different (p < 0.001) with a trend toward higher frequency of left main lesion in the FH group than in the group with no FH (7.9 vs. 0%). Culprit plaque was significantly shorter in patients with FH than those without FH (28.1 vs. 33.2 mm, p = 0.016). A trend toward higher prevalence of plaque with macrophage accumulation in patients with FH than those without FH (50.0 vs. 34.7%, p = 0.056) was observed, although the prevalence of other vulnerable characteristics including thin-cap fibroatheroma (TCFA) was comparable between patients with and without FH. Among patients with FH, significant increases in the prevalence of lipid-rich plaque (p = 0.028) and TCFA (p = 0.003) were observed according to the increase in low-density lipoprotein cholesterol (LDL-C) levels. Conclusions: Patients with FH had shorter culprit plaque without significant difference in the prevalence of vulnerable plaque components compared with patients without FH. A higher LDL-C level was associated with higher prevalence of vulnerable plaque in patients with FH.http://www.sciencedirect.com/science/article/pii/S2352551721000020Low-density lipoprotein cholesterolOptical coherence tomographyVulnerable plaque |
| spellingShingle | Masahiro Katamine Yoshiyasu Minami Takuya Hashimoto Junya Ako Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease Practical Laboratory Medicine Low-density lipoprotein cholesterol Optical coherence tomography Vulnerable plaque |
| title | Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease |
| title_full | Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease |
| title_fullStr | Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease |
| title_full_unstemmed | Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease |
| title_short | Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease |
| title_sort | familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease |
| topic | Low-density lipoprotein cholesterol Optical coherence tomography Vulnerable plaque |
| url | http://www.sciencedirect.com/science/article/pii/S2352551721000020 |
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