Altered topological organization of white matter structural networks in patients with neuromyelitis optica.
OBJECTIVE: To investigate the topological alterations of the whole-brain white-matter (WM) structural networks in patients with neuromyelitis optica (NMO). METHODS: The present study involved 26 NMO patients and 26 age- and sex-matched healthy controls. WM structural connectivity in each participant...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3492259?pdf=render |
| _version_ | 1818153947434582016 |
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| author | Yaou Liu Yunyun Duan Yong He Jun Wang Mingrui Xia Chunshui Yu Huiqing Dong Jing Ye Helmut Butzkueven Kuncheng Li Ni Shu |
| author_facet | Yaou Liu Yunyun Duan Yong He Jun Wang Mingrui Xia Chunshui Yu Huiqing Dong Jing Ye Helmut Butzkueven Kuncheng Li Ni Shu |
| author_sort | Yaou Liu |
| collection | DOAJ |
| description | OBJECTIVE: To investigate the topological alterations of the whole-brain white-matter (WM) structural networks in patients with neuromyelitis optica (NMO). METHODS: The present study involved 26 NMO patients and 26 age- and sex-matched healthy controls. WM structural connectivity in each participant was imaged with diffusion-weighted MRI and represented in terms of a connectivity matrix using deterministic tractography method. Graph theory-based analyses were then performed for the characterization of brain network properties. A multiple linear regression analysis was performed on each network metric between the NMO and control groups. RESULTS: The NMO patients exhibited abnormal small-world network properties, as indicated by increased normalized characteristic path length, increased normalized clustering and increased small-worldness. Furthermore, largely similar hub distributions of the WM structural networks were observed between NMO patients and healthy controls. However, regional efficiency in several brain areas of NMO patients was significantly reduced, which were mainly distributed in the default-mode, sensorimotor and visual systems. Furthermore, we have observed increased regional efficiency in a few brain regions such as the orbital parts of the superior and middle frontal and fusiform gyri. CONCLUSION: Although the NMO patients in this study had no discernible white matter T2 lesions in the brain, we hypothesize that the disrupted topological organization of WM networks provides additional evidence for subtle, widespread cerebral WM pathology in NMO. |
| first_indexed | 2024-12-11T14:18:42Z |
| format | Article |
| id | doaj.art-0513de49890b40b2a625181f24b9fc9d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T14:18:42Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-0513de49890b40b2a625181f24b9fc9d2022-12-22T01:03:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4884610.1371/journal.pone.0048846Altered topological organization of white matter structural networks in patients with neuromyelitis optica.Yaou LiuYunyun DuanYong HeJun WangMingrui XiaChunshui YuHuiqing DongJing YeHelmut ButzkuevenKuncheng LiNi ShuOBJECTIVE: To investigate the topological alterations of the whole-brain white-matter (WM) structural networks in patients with neuromyelitis optica (NMO). METHODS: The present study involved 26 NMO patients and 26 age- and sex-matched healthy controls. WM structural connectivity in each participant was imaged with diffusion-weighted MRI and represented in terms of a connectivity matrix using deterministic tractography method. Graph theory-based analyses were then performed for the characterization of brain network properties. A multiple linear regression analysis was performed on each network metric between the NMO and control groups. RESULTS: The NMO patients exhibited abnormal small-world network properties, as indicated by increased normalized characteristic path length, increased normalized clustering and increased small-worldness. Furthermore, largely similar hub distributions of the WM structural networks were observed between NMO patients and healthy controls. However, regional efficiency in several brain areas of NMO patients was significantly reduced, which were mainly distributed in the default-mode, sensorimotor and visual systems. Furthermore, we have observed increased regional efficiency in a few brain regions such as the orbital parts of the superior and middle frontal and fusiform gyri. CONCLUSION: Although the NMO patients in this study had no discernible white matter T2 lesions in the brain, we hypothesize that the disrupted topological organization of WM networks provides additional evidence for subtle, widespread cerebral WM pathology in NMO.http://europepmc.org/articles/PMC3492259?pdf=render |
| spellingShingle | Yaou Liu Yunyun Duan Yong He Jun Wang Mingrui Xia Chunshui Yu Huiqing Dong Jing Ye Helmut Butzkueven Kuncheng Li Ni Shu Altered topological organization of white matter structural networks in patients with neuromyelitis optica. PLoS ONE |
| title | Altered topological organization of white matter structural networks in patients with neuromyelitis optica. |
| title_full | Altered topological organization of white matter structural networks in patients with neuromyelitis optica. |
| title_fullStr | Altered topological organization of white matter structural networks in patients with neuromyelitis optica. |
| title_full_unstemmed | Altered topological organization of white matter structural networks in patients with neuromyelitis optica. |
| title_short | Altered topological organization of white matter structural networks in patients with neuromyelitis optica. |
| title_sort | altered topological organization of white matter structural networks in patients with neuromyelitis optica |
| url | http://europepmc.org/articles/PMC3492259?pdf=render |
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