Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection
Abstract Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug‐resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a rol...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-04-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20230044 |
| _version_ | 1797200563197181952 |
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| author | Hongxia Ruan Mengyuan Lyu Hongli Lai Lu Niu Zhenzhen Zhao Tangyuheng Liu Shuting Lei Binwu Ying |
| author_facet | Hongxia Ruan Mengyuan Lyu Hongli Lai Lu Niu Zhenzhen Zhao Tangyuheng Liu Shuting Lei Binwu Ying |
| author_sort | Hongxia Ruan |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug‐resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a role in determining immune outcomes. Several studies have established a strong correlation between cell death and TB progression. This review explores the molecular mechanisms of various cell death modes in Mycobacterium tuberculosis (Mtb) infection and how Mtb's virulence effectors regulate these pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis. Furthermore, therapeutic strategies targeting cell death pathways have shown promising results in TB treatment. Importantly, this review highlights the significant potential of mitochondria in mediating communication between different cell death modes and influencing the final outcomes. Overall, this work provides a comprehensive summary of the role of cell death in host immune responses and immune evasion by Mtb. It also offers valuable insights into the pathogenesis of TB and immune evasion strategies employed by Mtb and contributes to the development of more effective anti‐TB therapies. |
| first_indexed | 2024-04-24T07:33:38Z |
| format | Article |
| id | doaj.art-0513e58a25c54f7bb324b3ad8a0b992b |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-04-24T07:33:38Z |
| publishDate | 2024-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-0513e58a25c54f7bb324b3ad8a0b992b2024-04-20T10:27:31ZengWiley-VCHInterdisciplinary Medicine2832-62452024-04-0122n/an/a10.1002/INMD.20230044Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infectionHongxia Ruan0Mengyuan Lyu1Hongli Lai2Lu Niu3Zhenzhen Zhao4Tangyuheng Liu5Shuting Lei6Binwu Ying7Department of Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaInstitute of Thoracic Oncology West China Hospital Sichuan University Chengdu Sichuan ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaWest China School of Medicine Sichuan University Chengdu Sichuan ChinaDepartment of Laboratory Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaAbstract Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug‐resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a role in determining immune outcomes. Several studies have established a strong correlation between cell death and TB progression. This review explores the molecular mechanisms of various cell death modes in Mycobacterium tuberculosis (Mtb) infection and how Mtb's virulence effectors regulate these pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis. Furthermore, therapeutic strategies targeting cell death pathways have shown promising results in TB treatment. Importantly, this review highlights the significant potential of mitochondria in mediating communication between different cell death modes and influencing the final outcomes. Overall, this work provides a comprehensive summary of the role of cell death in host immune responses and immune evasion by Mtb. It also offers valuable insights into the pathogenesis of TB and immune evasion strategies employed by Mtb and contributes to the development of more effective anti‐TB therapies.https://doi.org/10.1002/INMD.20230044cell deathhost‐pathogen interactionMycobacterium tuberculosistuberculosis |
| spellingShingle | Hongxia Ruan Mengyuan Lyu Hongli Lai Lu Niu Zhenzhen Zhao Tangyuheng Liu Shuting Lei Binwu Ying Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection Interdisciplinary Medicine cell death host‐pathogen interaction Mycobacterium tuberculosis tuberculosis |
| title | Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection |
| title_full | Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection |
| title_fullStr | Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection |
| title_full_unstemmed | Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection |
| title_short | Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection |
| title_sort | host pathogen dialogues in different cell death modes during mycobacterium tuberculosis infection |
| topic | cell death host‐pathogen interaction Mycobacterium tuberculosis tuberculosis |
| url | https://doi.org/10.1002/INMD.20230044 |
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