Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer
This study aimed to evaluate the prognostic significance of 2-Deoxy-2-[<sup>18</sup>F]fluoro-D-glucose ([<sup>18</sup>F]FDG) uptake in the bone marrow (BM) and primary tumors on dual-time-point (DTP) PET/CT for predicting progression-free survival (PFS) and distant metastasis...
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| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/4/592 |
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| author | Sang Mi Lee Jeong Won Lee Ji-Hyun Lee In Young Jo Su Jin Jang |
| author_facet | Sang Mi Lee Jeong Won Lee Ji-Hyun Lee In Young Jo Su Jin Jang |
| author_sort | Sang Mi Lee |
| collection | DOAJ |
| description | This study aimed to evaluate the prognostic significance of 2-Deoxy-2-[<sup>18</sup>F]fluoro-D-glucose ([<sup>18</sup>F]FDG) uptake in the bone marrow (BM) and primary tumors on dual-time-point (DTP) PET/CT for predicting progression-free survival (PFS) and distant metastasis-free survival (DMFS) in patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed DTP [<sup>18</sup>F]FDG PET/CT images from 211 patients with NSCLC. The maximum standardized uptake value (SUV) of primary lung cancer and mean [<sup>18</sup>F]FDG uptake of the BM (BM SUV) were measured from early and delayed PET/CT images, and the percent changes in these parameters (∆maximum SUV and ∆BM SUV) were calculated. On multivariate survival analysis, the maximum SUV and BM SUV on both early and delayed PET/CT scans were significantly associated with PFS, while the ∆maximum SUV and ∆BM SUV failed to show statistical significance. For DMFS, the ∆maximum SUV and ∆BM SUV were independent predictors along with the TNM stage. Distant progression was observed only in 1.3% of patients with low ∆maximum SUV and ∆BM SUV, whereas 28.2% of patients with high ∆maximum SUV and ∆BM SUV experienced distant progression. The ∆maximum SUV and ∆BM SUV on DTP [<sup>18</sup>F]FDG PET/CT were significant independent predictors for DMFS in patients with NSCLC. |
| first_indexed | 2024-03-09T10:32:40Z |
| format | Article |
| id | doaj.art-051482762d824ec1b80e2a07d6f0efbb |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T10:32:40Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-051482762d824ec1b80e2a07d6f0efbb2023-12-01T21:08:54ZengMDPI AGJournal of Personalized Medicine2075-44262022-04-0112459210.3390/jpm12040592Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung CancerSang Mi Lee0Jeong Won Lee1Ji-Hyun Lee2In Young Jo3Su Jin Jang4Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, KoreaDepartment of Nuclear Medicine, International St. Mary’s Hospital, Catholic Kwandong University, Incheon 22711, KoreaDepartment of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, Seongnam 13496, KoreaDepartment of Radiation Oncology, Soonchunhyang University Cheonan Hospital, Cheonan 31151, KoreaDepartment of Nuclear Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13496, KoreaThis study aimed to evaluate the prognostic significance of 2-Deoxy-2-[<sup>18</sup>F]fluoro-D-glucose ([<sup>18</sup>F]FDG) uptake in the bone marrow (BM) and primary tumors on dual-time-point (DTP) PET/CT for predicting progression-free survival (PFS) and distant metastasis-free survival (DMFS) in patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed DTP [<sup>18</sup>F]FDG PET/CT images from 211 patients with NSCLC. The maximum standardized uptake value (SUV) of primary lung cancer and mean [<sup>18</sup>F]FDG uptake of the BM (BM SUV) were measured from early and delayed PET/CT images, and the percent changes in these parameters (∆maximum SUV and ∆BM SUV) were calculated. On multivariate survival analysis, the maximum SUV and BM SUV on both early and delayed PET/CT scans were significantly associated with PFS, while the ∆maximum SUV and ∆BM SUV failed to show statistical significance. For DMFS, the ∆maximum SUV and ∆BM SUV were independent predictors along with the TNM stage. Distant progression was observed only in 1.3% of patients with low ∆maximum SUV and ∆BM SUV, whereas 28.2% of patients with high ∆maximum SUV and ∆BM SUV experienced distant progression. The ∆maximum SUV and ∆BM SUV on DTP [<sup>18</sup>F]FDG PET/CT were significant independent predictors for DMFS in patients with NSCLC.https://www.mdpi.com/2075-4426/12/4/592bone marrowfluorodeoxyglucose F-18non-small cell lung cancerpositron emission tomographyprognosis |
| spellingShingle | Sang Mi Lee Jeong Won Lee Ji-Hyun Lee In Young Jo Su Jin Jang Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer Journal of Personalized Medicine bone marrow fluorodeoxyglucose F-18 non-small cell lung cancer positron emission tomography prognosis |
| title | Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer |
| title_full | Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer |
| title_fullStr | Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer |
| title_full_unstemmed | Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer |
| title_short | Prognostic Value of Dual-Time-Point [<sup>18</sup>F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer |
| title_sort | prognostic value of dual time point sup 18 sup f fdg pet ct for predicting distant metastasis after treatment in patients with non small cell lung cancer |
| topic | bone marrow fluorodeoxyglucose F-18 non-small cell lung cancer positron emission tomography prognosis |
| url | https://www.mdpi.com/2075-4426/12/4/592 |
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