EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW)
Currently we are facing a revolution in therapy of chronic lymphocytic leukemia, related to the development of novel target drugs, which have markedly improved treatment results in all groups of patients. While inhibitors of Bruton’s tyrosine kinase (ibrutinib, acalabrutinib etc.) and phosphatidylin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2018-02-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/263 |
| _version_ | 1797855516977790976 |
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| author | V. V. Strugov E. A. Stadnik A. Yu. Zaritskey |
| author_facet | V. V. Strugov E. A. Stadnik A. Yu. Zaritskey |
| author_sort | V. V. Strugov |
| collection | DOAJ |
| description | Currently we are facing a revolution in therapy of chronic lymphocytic leukemia, related to the development of novel target drugs, which have markedly improved treatment results in all groups of patients. While inhibitors of Bruton’s tyrosine kinase (ibrutinib, acalabrutinib etc.) and phosphatidylinositol-3 kinase isoforms (idelalisib, umbralisib etc.) are currently in the spotlight, much less attention is paid to antiapoptotic protein inhibitors such as venetoclax. In this review we summarize the results of venetoclax clinical studies in CLL as monotherapy and in combinations. The drug is distinguished by a high rate of complete responses and minimal residual disease eradication in high risk CLL patients, as well as a favorable toxicity profile. This makes it an ideal component of non-genotoxic regimens, aimed at the cure of the disease. |
| first_indexed | 2024-04-09T20:24:57Z |
| format | Article |
| id | doaj.art-0515099d9c794a59b7b3bae78f03019c |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:24:57Z |
| publishDate | 2018-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-0515099d9c794a59b7b3bae78f03019c2023-03-30T20:15:11ZrusABV-pressОнкогематология1818-83462413-40232018-02-01124182610.17650/1818-8346-2017-12-4-18-26250EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW)V. V. Strugov0E. A. Stadnik1A. Yu. Zaritskey2Almazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreCurrently we are facing a revolution in therapy of chronic lymphocytic leukemia, related to the development of novel target drugs, which have markedly improved treatment results in all groups of patients. While inhibitors of Bruton’s tyrosine kinase (ibrutinib, acalabrutinib etc.) and phosphatidylinositol-3 kinase isoforms (idelalisib, umbralisib etc.) are currently in the spotlight, much less attention is paid to antiapoptotic protein inhibitors such as venetoclax. In this review we summarize the results of venetoclax clinical studies in CLL as monotherapy and in combinations. The drug is distinguished by a high rate of complete responses and minimal residual disease eradication in high risk CLL patients, as well as a favorable toxicity profile. This makes it an ideal component of non-genotoxic regimens, aimed at the cure of the disease.https://oncohematology.abvpress.ru/ongm/article/view/263chronic lymphocytic leukemiavenetoclaxantiapoptotic protein bcl-2 |
| spellingShingle | V. V. Strugov E. A. Stadnik A. Yu. Zaritskey EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW) Онкогематология chronic lymphocytic leukemia venetoclax antiapoptotic protein bcl-2 |
| title | EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW) |
| title_full | EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW) |
| title_fullStr | EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW) |
| title_full_unstemmed | EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW) |
| title_short | EFFECTIVENESS OF VENETOСLAX IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (LITERATURE REVIEW) |
| title_sort | effectiveness of venetoсlax in the treatment of chronic lymphocytic leukemia literature review |
| topic | chronic lymphocytic leukemia venetoclax antiapoptotic protein bcl-2 |
| url | https://oncohematology.abvpress.ru/ongm/article/view/263 |
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