Synthesis of Altissimacoumarin D and Other Prenylated Coumarins and Their Ability to Reverse the Multidrug Resistance Phenotype in <i>Candida albicans</i>

Synthesis of Altissimacoumarin D and Other Prenylated Coumarins and Their Ability to Reverse the Multidrug Resistance Phenotype in <i>Candida albicans</i>

Azoles are the main antifungal agents employed in clinical practice to treat invasive candidiasis. Nonetheless, their efficacy is limited by fungal resistance mechanisms, mainly the overexpression of efflux pumps. Consequently, candidiasis has a worrisome death rate of 75%. One potential strategy to...

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Bibliographic Details
Main Authors: Anna Claudia Silva, Daniel Clemente de Moraes, Denilson Costa do Carmo, Giselle Cristina Casaes Gomes, A. Ganesan, Rosangela Sabbatini Capella Lopes, Antonio Ferreira-Pereira, Cláudio Cerqueira Lopes
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Journal of Fungi
Subjects:
altissimacoumarin D
<i>Candida</i> spp.
coumarins
efflux transporters
isofraxidin
multidrug resistance
Online Access:https://www.mdpi.com/2309-608X/9/7/758

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