Essences in Metabolic Engineering of Lignan Biosynthesis
Lignans are structurally and functionally diverse phytochemicals biosynthesized in diverse plant species and have received wide attentions as leading compounds of novel drugs for tumor treatment and healthy diets to reduce of the risks of lifestyle-related non-communicable diseases. However, the li...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-05-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-1989/5/2/270 |
| _version_ | 1818541820758458368 |
|---|---|
| author | Honoo Satake Tomotsugu Koyama Sedigheh Esmaeilzadeh Bahabadi Erika Matsumoto Eiichiro Ono Jun Murata |
| author_facet | Honoo Satake Tomotsugu Koyama Sedigheh Esmaeilzadeh Bahabadi Erika Matsumoto Eiichiro Ono Jun Murata |
| author_sort | Honoo Satake |
| collection | DOAJ |
| description | Lignans are structurally and functionally diverse phytochemicals biosynthesized in diverse plant species and have received wide attentions as leading compounds of novel drugs for tumor treatment and healthy diets to reduce of the risks of lifestyle-related non-communicable diseases. However, the lineage-specific distribution and the low-amount of production in natural plants, some of which are endangered species, hinder the efficient and stable production of beneficial lignans. Accordingly, the development of new procedures for lignan production is of keen interest. Recent marked advances in the molecular and functional characterization of lignan biosynthetic enzymes and endogenous and exogenous factors for lignan biosynthesis have suggested new methods for the metabolic engineering of lignan biosynthesis cascades leading to the efficient, sustainable, and stable lignan production in plants, including plant cell/organ cultures. Optimization of light conditions, utilization of a wide range of elicitor treatments, and construction of transiently gene-transfected or transgenic lignan-biosynthesizing plants are mainly being attempted. This review will present the basic and latest knowledge regarding metabolic engineering of lignans based on their biosynthetic pathways and biological activities, and the perspectives in lignan production via metabolic engineering. |
| first_indexed | 2024-12-11T22:14:11Z |
| format | Article |
| id | doaj.art-051775cf605f4ad39b014c7de61734f5 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-12-11T22:14:11Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-051775cf605f4ad39b014c7de61734f52022-12-22T00:48:39ZengMDPI AGMetabolites2218-19892015-05-015227029010.3390/metabo5020270metabo5020270Essences in Metabolic Engineering of Lignan BiosynthesisHonoo Satake0Tomotsugu Koyama1Sedigheh Esmaeilzadeh Bahabadi2Erika Matsumoto3Eiichiro Ono4Jun Murata5Bioorganic Research Institute, Suntory Foundation for Life Sciences, Osaka 618-8503, JapanBioorganic Research Institute, Suntory Foundation for Life Sciences, Osaka 618-8503, JapanDepartment of Biology, Faculty of Basic Sciences, University of Zabol, Zabol, IranBioorganic Research Institute, Suntory Foundation for Life Sciences, Osaka 618-8503, JapanResearch Institute, Suntory Global Innovation Center (SIC) Ltd., Osaka 618-8503, JapanBioorganic Research Institute, Suntory Foundation for Life Sciences, Osaka 618-8503, JapanLignans are structurally and functionally diverse phytochemicals biosynthesized in diverse plant species and have received wide attentions as leading compounds of novel drugs for tumor treatment and healthy diets to reduce of the risks of lifestyle-related non-communicable diseases. However, the lineage-specific distribution and the low-amount of production in natural plants, some of which are endangered species, hinder the efficient and stable production of beneficial lignans. Accordingly, the development of new procedures for lignan production is of keen interest. Recent marked advances in the molecular and functional characterization of lignan biosynthetic enzymes and endogenous and exogenous factors for lignan biosynthesis have suggested new methods for the metabolic engineering of lignan biosynthesis cascades leading to the efficient, sustainable, and stable lignan production in plants, including plant cell/organ cultures. Optimization of light conditions, utilization of a wide range of elicitor treatments, and construction of transiently gene-transfected or transgenic lignan-biosynthesizing plants are mainly being attempted. This review will present the basic and latest knowledge regarding metabolic engineering of lignans based on their biosynthetic pathways and biological activities, and the perspectives in lignan production via metabolic engineering.http://www.mdpi.com/2218-1989/5/2/270lignanbiosynthesismetabolic engineeringelicitortransgenic plant |
| spellingShingle | Honoo Satake Tomotsugu Koyama Sedigheh Esmaeilzadeh Bahabadi Erika Matsumoto Eiichiro Ono Jun Murata Essences in Metabolic Engineering of Lignan Biosynthesis Metabolites lignan biosynthesis metabolic engineering elicitor transgenic plant |
| title | Essences in Metabolic Engineering of Lignan Biosynthesis |
| title_full | Essences in Metabolic Engineering of Lignan Biosynthesis |
| title_fullStr | Essences in Metabolic Engineering of Lignan Biosynthesis |
| title_full_unstemmed | Essences in Metabolic Engineering of Lignan Biosynthesis |
| title_short | Essences in Metabolic Engineering of Lignan Biosynthesis |
| title_sort | essences in metabolic engineering of lignan biosynthesis |
| topic | lignan biosynthesis metabolic engineering elicitor transgenic plant |
| url | http://www.mdpi.com/2218-1989/5/2/270 |
| work_keys_str_mv | AT honoosatake essencesinmetabolicengineeringoflignanbiosynthesis AT tomotsugukoyama essencesinmetabolicengineeringoflignanbiosynthesis AT sedighehesmaeilzadehbahabadi essencesinmetabolicengineeringoflignanbiosynthesis AT erikamatsumoto essencesinmetabolicengineeringoflignanbiosynthesis AT eiichiroono essencesinmetabolicengineeringoflignanbiosynthesis AT junmurata essencesinmetabolicengineeringoflignanbiosynthesis |