Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy
Оn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a week. Group II (n = 19) received standard therapy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2005-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2492 |
| _version_ | 1797857262500315136 |
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| author | I. G. Gordeev E. E. Ilina V. A. Lusov N. A. Volov E. A. Bekchiu A. Yu. Lebedeva |
| author_facet | I. G. Gordeev E. E. Ilina V. A. Lusov N. A. Volov E. A. Bekchiu A. Yu. Lebedeva |
| author_sort | I. G. Gordeev |
| collection | DOAJ |
| description | Оn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a week. Group II (n = 19) received standard therapy, plus trimethazidine (Preductal MB), 70 mg/d. Group III (n = 20) did not receive any metabolic medications. Dynamics of lipid peroxidation and protective antioxidant systems status was assessed during first 24 hours after surgery. Blood samples were collected before the intervention, 6 and 24 hours later. Cardioprotectors mildronate and trimethazidin, administered before surgery, decreased blood levels of lipid peroxidation products, due to activation of protective antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GP). |
| first_indexed | 2024-04-09T20:53:52Z |
| format | Article |
| id | doaj.art-0519470b975d451085daec020ec11170 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:53:52Z |
| publishDate | 2005-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-0519470b975d451085daec020ec111702023-03-29T21:23:11Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202005-02-010141462220Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapyI. G. Gordeev0E. E. Ilina1V. A. Lusov2N. A. Volov3E. A. Bekchiu4A. Yu. Lebedeva5Российский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетОn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a week. Group II (n = 19) received standard therapy, plus trimethazidine (Preductal MB), 70 mg/d. Group III (n = 20) did not receive any metabolic medications. Dynamics of lipid peroxidation and protective antioxidant systems status was assessed during first 24 hours after surgery. Blood samples were collected before the intervention, 6 and 24 hours later. Cardioprotectors mildronate and trimethazidin, administered before surgery, decreased blood levels of lipid peroxidation products, due to activation of protective antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GP).https://russjcardiol.elpub.ru/jour/article/view/2492antioxidant systemslipid peroxidationstate after coronary bypass surgerycardioprotectors |
| spellingShingle | I. G. Gordeev E. E. Ilina V. A. Lusov N. A. Volov E. A. Bekchiu A. Yu. Lebedeva Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy Российский кардиологический журнал antioxidant systems lipid peroxidation state after coronary bypass surgery cardioprotectors |
| title | Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy |
| title_full | Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy |
| title_fullStr | Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy |
| title_full_unstemmed | Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy |
| title_short | Lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy |
| title_sort | lipid peroxidation and protective antioxidant systems in coronary bypass surgery and cardioprotective therapy |
| topic | antioxidant systems lipid peroxidation state after coronary bypass surgery cardioprotectors |
| url | https://russjcardiol.elpub.ru/jour/article/view/2492 |
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