Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

IntroductionT cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies. Despite the emergence of multiple TIGIT-blocking agents entering clinic...

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Bibliographic Details
Main Authors: Katty Zeven, Timo W.M. De Groof, Hannelore Ceuppens, Robin Maximilian Awad, Thomas Ertveldt, Wout de Mey, Fien Meeus, Geert Raes, Karine Breckpot, Nick Devoogdt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
TIGIT
immune checkpoint (ICP)
nuclear imaging
noninvasive diagnosis
tracer development
nanobodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268900/full

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