Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children
The objective: to determine severity of changes in the hemostasis system in children occurring at main stages of liver resection as well as the need for their intraoperative correction.Subjects and Methods. A single-center prospective pilot study of coagulogram and rotational thromboelastometry valu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2022-07-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/672 |
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| author | D. I. Novikov A. Yu. Zaitsev K. V. Dubrovin E. K. Bespalov A. V. Filin |
| author_facet | D. I. Novikov A. Yu. Zaitsev K. V. Dubrovin E. K. Bespalov A. V. Filin |
| author_sort | D. I. Novikov |
| collection | DOAJ |
| description | The objective: to determine severity of changes in the hemostasis system in children occurring at main stages of liver resection as well as the need for their intraoperative correction.Subjects and Methods. A single-center prospective pilot study of coagulogram and rotational thromboelastometry values was conducted in 25 children aged 0–11 years old with hepatoblastoma after a course of chemotherapy according to the PRETEX IV regimen who underwent hemihepatectomy.Results. There were no statistically significant differences in parameters of the ROTEM tests both when comparing groups and when comparing hemihepatectomy stages within the same age group of patients. At the beginning of the separation of the liver parenchyma INTEM: CT 200.00 (186.00; 238.00), CFT 88.00 (83.00; 139.00), MCF 54.00 (51.00; 61.00), ML 0.00 (0.00; 5.00) in Group I, CT 191.00 (179.00; 199.00), CFT 84.00 (79.00; 103.00), MCF 60.00 (58.00; 64.00), 4,00 (3.00; 9.00) in Group II, respectively, p > 0.05. After separation of the liver parenchyma INTEM: CT 201.00 (161.00; 237.50), CFT 93.00 (95.00; 112.00), MCF 54.00 (52.50; 59.50), ML 6.00 (2.00; 10.00) in Group I, CT 229.00 (201.00; 285.00), CFT 93.00 (78.00; 177.00), MCF 59.00 (49.00; 60.00), ML 5.00 (5.00; 10.00) in Group II, respectively, p > 0.05.Conclusion. After chemotherapy courses, children aged 0–11 years suffering from hepatoblastoma, maintain normal functional activity of the hemostasis system at all stages of surgical treatment. In children under 11 years of age, routine hemostasis correction with blood products and prothrombin complex factor concentrate is not required during the main stages of hemihepatectomy. |
| first_indexed | 2024-03-12T04:20:33Z |
| format | Article |
| id | doaj.art-051ae9bf00514ddca32a062c092c24ae |
| institution | Directory Open Access Journal |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| last_indexed | 2024-03-12T04:20:33Z |
| publishDate | 2022-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj.art-051ae9bf00514ddca32a062c092c24ae2023-09-03T10:33:18ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532022-07-01193414810.21292/2078-5658-2022-19-3-41-48525Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in ChildrenD. I. Novikov0A. Yu. Zaitsev1K. V. Dubrovin2E. K. Bespalov3A. V. Filin4Российский научный центр хирургии им. акад. Б. В. ПетровскогоРоссийский научный центр хирургии им. акад. Б. В. Петровского; Первый Московский государственный медицинский университет им. И. М. Сеченова МЗ РФ (Сеченовский университет)Российский научный центр хирургии им. акад. Б. В. Петровского; Первый Московский государственный медицинский университет им. И. М. Сеченова МЗ РФ (Сеченовский университет)Российский научный центр хирургии им. акад. Б. В. ПетровскогоРоссийский научный центр хирургии им. акад. Б. В. ПетровскогоThe objective: to determine severity of changes in the hemostasis system in children occurring at main stages of liver resection as well as the need for their intraoperative correction.Subjects and Methods. A single-center prospective pilot study of coagulogram and rotational thromboelastometry values was conducted in 25 children aged 0–11 years old with hepatoblastoma after a course of chemotherapy according to the PRETEX IV regimen who underwent hemihepatectomy.Results. There were no statistically significant differences in parameters of the ROTEM tests both when comparing groups and when comparing hemihepatectomy stages within the same age group of patients. At the beginning of the separation of the liver parenchyma INTEM: CT 200.00 (186.00; 238.00), CFT 88.00 (83.00; 139.00), MCF 54.00 (51.00; 61.00), ML 0.00 (0.00; 5.00) in Group I, CT 191.00 (179.00; 199.00), CFT 84.00 (79.00; 103.00), MCF 60.00 (58.00; 64.00), 4,00 (3.00; 9.00) in Group II, respectively, p > 0.05. After separation of the liver parenchyma INTEM: CT 201.00 (161.00; 237.50), CFT 93.00 (95.00; 112.00), MCF 54.00 (52.50; 59.50), ML 6.00 (2.00; 10.00) in Group I, CT 229.00 (201.00; 285.00), CFT 93.00 (78.00; 177.00), MCF 59.00 (49.00; 60.00), ML 5.00 (5.00; 10.00) in Group II, respectively, p > 0.05.Conclusion. After chemotherapy courses, children aged 0–11 years suffering from hepatoblastoma, maintain normal functional activity of the hemostasis system at all stages of surgical treatment. In children under 11 years of age, routine hemostasis correction with blood products and prothrombin complex factor concentrate is not required during the main stages of hemihepatectomy.https://www.vair-journal.com/jour/article/view/672резекция печенисистема гемостазагемостазкоагуляционный профильгепатобластомадети |
| spellingShingle | D. I. Novikov A. Yu. Zaitsev K. V. Dubrovin E. K. Bespalov A. V. Filin Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children Вестник анестезиологии и реаниматологии резекция печени система гемостаза гемостаз коагуляционный профиль гепатобластома дети |
| title | Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children |
| title_full | Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children |
| title_fullStr | Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children |
| title_full_unstemmed | Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children |
| title_short | Specific Parameters of Intraoperative Changes in the Hemostasis System during Liver Resection in Children |
| title_sort | specific parameters of intraoperative changes in the hemostasis system during liver resection in children |
| topic | резекция печени система гемостаза гемостаз коагуляционный профиль гепатобластома дети |
| url | https://www.vair-journal.com/jour/article/view/672 |
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