Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report
Abstract Background Although paediatric patients with acute lymphoblastic leukaemia (ALL) have improved survival following modern chemotherapy treatment, disease relapses still occur in 20–25% of them. Our case had relapsed ALL with testicular leukaemic infiltration, which is rare, with less than 2%...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-023-01179-7 |
| _version_ | 1797363481409748992 |
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| author | Abdul Qadir Qader Javid Akhgar Stephanie Wai Yee Tan Hamzaini Abdul Hamid |
| author_facet | Abdul Qadir Qader Javid Akhgar Stephanie Wai Yee Tan Hamzaini Abdul Hamid |
| author_sort | Abdul Qadir Qader |
| collection | DOAJ |
| description | Abstract Background Although paediatric patients with acute lymphoblastic leukaemia (ALL) have improved survival following modern chemotherapy treatment, disease relapses still occur in 20–25% of them. Our case had relapsed ALL with testicular leukaemic infiltration, which is rare, with less than 2% incidence. Case presentation We describe a case of an 11-year-old boy with a background history of ALL presenting with painless unilateral scrotal swelling. An initial ultrasound of the testes showed heterogeneity throughout with hypervascularity on colour-flow imaging on the affected testis. Some areas are hypoechoic with dilated tubules. The histopathology of the follow-up testicular biopsy revealed malignant cells and leukaemic infiltration. Patient subsequently received chemotherapy treatment at another centre. Conclusions Testicular relapse of ALL is relatively rare with the use of improved contemporary frontline treatment with better outcomes. With its non-specific symptoms, radiological imaging can significantly facilitate timely diagnosis and contribute to appropriate further management and improved prognosis. |
| first_indexed | 2024-03-08T16:21:59Z |
| format | Article |
| id | doaj.art-051af35a8a1540598f0180b28332566c |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-03-08T16:21:59Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-051af35a8a1540598f0180b28332566c2024-01-07T12:17:13ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622024-01-015511610.1186/s43055-023-01179-7Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case reportAbdul Qadir Qader0Javid Akhgar1Stephanie Wai Yee Tan2Hamzaini Abdul Hamid3Radiology Department, Faculty of Medicine, Herat UniversityOrthopaedic and Spine Surgery Department, Jami HospitalPharmacy Department, Universiti Kebangsaan Malaysia Medical CentreRadiology Department, Universiti Kebangsaan Malaysia Medical CentreAbstract Background Although paediatric patients with acute lymphoblastic leukaemia (ALL) have improved survival following modern chemotherapy treatment, disease relapses still occur in 20–25% of them. Our case had relapsed ALL with testicular leukaemic infiltration, which is rare, with less than 2% incidence. Case presentation We describe a case of an 11-year-old boy with a background history of ALL presenting with painless unilateral scrotal swelling. An initial ultrasound of the testes showed heterogeneity throughout with hypervascularity on colour-flow imaging on the affected testis. Some areas are hypoechoic with dilated tubules. The histopathology of the follow-up testicular biopsy revealed malignant cells and leukaemic infiltration. Patient subsequently received chemotherapy treatment at another centre. Conclusions Testicular relapse of ALL is relatively rare with the use of improved contemporary frontline treatment with better outcomes. With its non-specific symptoms, radiological imaging can significantly facilitate timely diagnosis and contribute to appropriate further management and improved prognosis.https://doi.org/10.1186/s43055-023-01179-7Testis leukaemic infiltrationAcute lymphoblastic leukaemiaCase report |
| spellingShingle | Abdul Qadir Qader Javid Akhgar Stephanie Wai Yee Tan Hamzaini Abdul Hamid Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report The Egyptian Journal of Radiology and Nuclear Medicine Testis leukaemic infiltration Acute lymphoblastic leukaemia Case report |
| title | Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report |
| title_full | Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report |
| title_fullStr | Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report |
| title_full_unstemmed | Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report |
| title_short | Testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia: a case report |
| title_sort | testicular leukaemic infiltration in relapsed acute lymphoblastic leukaemia a case report |
| topic | Testis leukaemic infiltration Acute lymphoblastic leukaemia Case report |
| url | https://doi.org/10.1186/s43055-023-01179-7 |
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