The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts
Objective Metabolic dysregulation frequently co‐occurs with obesity, which has been shown to be a risk factor for lower extremity osteoarthritis (OA). We evaluated the association between metabolic syndrome (MetS), alone and in combination with obesity, and hip OA. Methods In two parallel cross‐sect...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
|
| Series: | ACR Open Rheumatology |
| Online Access: | https://doi.org/10.1002/acr2.11518 |
| _version_ | 1797871766528327680 |
|---|---|
| author | Karen Y. Cheng Elsa S. Strotmeyer Deborah M. Kado John T. Schousboe Simon Schenk Michael Nevitt Nancy E. Lane Jan M. Hughes‐Austin |
| author_facet | Karen Y. Cheng Elsa S. Strotmeyer Deborah M. Kado John T. Schousboe Simon Schenk Michael Nevitt Nancy E. Lane Jan M. Hughes‐Austin |
| author_sort | Karen Y. Cheng |
| collection | DOAJ |
| description | Objective Metabolic dysregulation frequently co‐occurs with obesity, which has been shown to be a risk factor for lower extremity osteoarthritis (OA). We evaluated the association between metabolic syndrome (MetS), alone and in combination with obesity, and hip OA. Methods In two parallel cross‐sectional analyses, we studied 403 women from the Study of Osteoporotic Fractures (SOF) and 2354 men from the Osteoporotic Fractures in Men (MrOS) study. We used multivariable logistic regression to evaluate associations of obesity (body mass index ≥30 kg/m2) and/or MetS (three of five National Cholesterol Education Program Adult Treatment Panel III criteria) with clinical hip OA, defined as a modified Croft score of 2 or more or total hip replacement, and pain or limited range of motion. Our analysis adjusted for demographics. Results Approximately 3.5% of SOF women and 5.4% of MrOS men had clinical hip OA. Among women, obesity was not associated with hip OA, yet those with MetS had a 365% higher odds of hip OA (95% CI: 1.37‐15.83). Among men, those who had obesity had a 115% higher odds of hip OA (95% CI: 1.39‐3.32), yet MetS was not associated with hip OA. There was no interaction between MetS, obesity, and hip OA in either women or men. Conclusion In women, but not in men, MetS was associated with hip OA. In men, but not in women, obesity was associated with hip OA. These findings suggest that mechanical effects of obesity may predominate in the pathogenesis of hip OA in men, whereas metabolic effects predominate in women. |
| first_indexed | 2024-04-10T00:49:18Z |
| format | Article |
| id | doaj.art-051b4d8365f24119bcb65fb8c5ca38f3 |
| institution | Directory Open Access Journal |
| issn | 2578-5745 |
| language | English |
| last_indexed | 2024-04-10T00:49:18Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | ACR Open Rheumatology |
| spelling | doaj.art-051b4d8365f24119bcb65fb8c5ca38f32023-03-13T16:30:17ZengWileyACR Open Rheumatology2578-57452023-03-015311512310.1002/acr2.11518The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study CohortsKaren Y. Cheng0Elsa S. Strotmeyer1Deborah M. Kado2John T. Schousboe3Simon Schenk4Michael Nevitt5Nancy E. Lane6Jan M. Hughes‐Austin7University of California San Diego La Jolla CaliforniaUniversity of Pittsburgh Pittsburgh PennsylvaniaStanford University, Stanford, and Geriatric Research Education and Clinical Center Palo Alto CaliforniaPark Nicollet Clinic and Health Partners Institute Bloomington MinnesotaUniversity of California San Diego La Jolla CaliforniaUniversity of California San Francisco San Francisco, CaliforniaUniversity of California Davis Davis, CaliforniaUniversity of California San Diego La Jolla CaliforniaObjective Metabolic dysregulation frequently co‐occurs with obesity, which has been shown to be a risk factor for lower extremity osteoarthritis (OA). We evaluated the association between metabolic syndrome (MetS), alone and in combination with obesity, and hip OA. Methods In two parallel cross‐sectional analyses, we studied 403 women from the Study of Osteoporotic Fractures (SOF) and 2354 men from the Osteoporotic Fractures in Men (MrOS) study. We used multivariable logistic regression to evaluate associations of obesity (body mass index ≥30 kg/m2) and/or MetS (three of five National Cholesterol Education Program Adult Treatment Panel III criteria) with clinical hip OA, defined as a modified Croft score of 2 or more or total hip replacement, and pain or limited range of motion. Our analysis adjusted for demographics. Results Approximately 3.5% of SOF women and 5.4% of MrOS men had clinical hip OA. Among women, obesity was not associated with hip OA, yet those with MetS had a 365% higher odds of hip OA (95% CI: 1.37‐15.83). Among men, those who had obesity had a 115% higher odds of hip OA (95% CI: 1.39‐3.32), yet MetS was not associated with hip OA. There was no interaction between MetS, obesity, and hip OA in either women or men. Conclusion In women, but not in men, MetS was associated with hip OA. In men, but not in women, obesity was associated with hip OA. These findings suggest that mechanical effects of obesity may predominate in the pathogenesis of hip OA in men, whereas metabolic effects predominate in women.https://doi.org/10.1002/acr2.11518 |
| spellingShingle | Karen Y. Cheng Elsa S. Strotmeyer Deborah M. Kado John T. Schousboe Simon Schenk Michael Nevitt Nancy E. Lane Jan M. Hughes‐Austin The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts ACR Open Rheumatology |
| title | The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts |
| title_full | The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts |
| title_fullStr | The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts |
| title_full_unstemmed | The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts |
| title_short | The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts |
| title_sort | association of metabolic syndrome and obesity with clinical hip osteoarthritis in the study of osteoporotic fractures and the osteoporotic fractures in men study cohorts |
| url | https://doi.org/10.1002/acr2.11518 |
| work_keys_str_mv | AT karenycheng theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT elsasstrotmeyer theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT deborahmkado theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT johntschousboe theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT simonschenk theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT michaelnevitt theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT nancyelane theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT janmhughesaustin theassociationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT karenycheng associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT elsasstrotmeyer associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT deborahmkado associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT johntschousboe associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT simonschenk associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT michaelnevitt associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT nancyelane associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts AT janmhughesaustin associationofmetabolicsyndromeandobesitywithclinicalhiposteoarthritisinthestudyofosteoporoticfracturesandtheosteoporoticfracturesinmenstudycohorts |